reports hero background
UPDATED: Nov 18, 2025

Stock Analysis

$38.85
-$1.08 |-2.70%
Day Range:
$38.75 - $40.11
Market Cap:
1.78B
P/E Ratio:
0.0000
Avg Value:
$25.23
Year Range:
$7.26 - $43.20
1
General Information
Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefit to CF patients.

CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.

2
Sionna Therapeutics (SION) Stock Graph
3
How We Grade Sionna Therapeutics (SION)

We grade stocks based on past performance, their future growth potential, intrinsic value, dividend history, and overall financial health.

The chart below shows how we grade Sionna Therapeutics (SION) across the board compared to its closest peers.

4
Benzinga Edge Rankings

Benzinga Edge stock rankings give you four critical scores to help you identify the strongest and weakest stocks to buy and sell.

5
Peer Ratings

See how Sionna Therapeutics compares to its peers in these key performance metrics from Benzinga Rankings.

Top Peers
Value
Quality
Growth
Momentum
Short
Medium
Long
DNTHDianthus Therapeutics
0
0
0
94.12
ZYMEZymeworks
0
0
0
92.84
PGENPrecigen
0
0
0
99.29
JANXJanux Therapeutics
0
0
0
24.14
Short: price trend over the last couple of months
Medium: price trend over the last couple of quarters
Long: price trend over the past year
Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
6
Future Growth
Our estimate of future price growth is based on an aggregation of 0 analyst ratings over the past 3 months and their 12-month price targets.

Below, you can see that analysts are estimating a 12-month price target range of $22.00 - $46.00 with an average of $37.75

-5.46%
Expected movement for Sionna Therapeutics (SION) over the next 12 months
Based on these rankings

Recent Ratings for Sionna Therapeutics (SION)

7
Past Performance
How has Sionna Therapeutics (SION) performed over the past 5 years?

The two main factors that we consider when analyzing past performance is overall return and volatility

Using these two metrics, we can determine if this stock gave its investors enough return for the risk that they took on by owning it. This is measured by the sharpe ratio, which has been used as a primary measure of risk/reward trade-off for almost 60 years.

This ratio can be interpreted as the amount of return an investor has received for the amount of risk that they took on by owning the stock over that timeframe.

Sionna Therapeutics (SION) sharpe ratio over the past 5 years is 0.2007 which is considered to be above average compared to the peer average of -0.2100