La catena delle opzioni mostra i dati chiave delle opzioni azionarie di CytoDyn a vari prezzi di esercizio e date di scadenza. I trader utilizzano queste informazioni per analizzare potenziali operazioni e valutare il sentiment del mercato per CytoDyn..

CytoDyn (OTC:CYDY) Azioni, Catena delle Opzioni

CytoDyn Inc is a USA-based clinical-stage biotechnology company that focuses on the clinical development and potential commercialization of humanized monoclonal antibodies to treat Human Immunodeficiency Virus (HIV) infection. The product candidate is PRO 140, which is a class of HIV therapy called entry inhibitors that block HIV from entering into and infecting certain cells. The company emphasizes exploring opportunities for clinical applications for PRO 140 involving the CCR5 (C-C chemokine receptor type 5) receptor, other than HIV-related treatments, such as inflammatory conditions, autoimmune diseases, and cancer.

CytoDyn Inc

Terms of the settlement include $12,000,000 cash payment to CytoDyn and elimination of $14,000,000 accounts payable liability from the Company's balance sheet

News

Legal

CYDY

CytoDyn Settles With Amarex Clinical Research; Amarex To Pay $12M To CytoDyn, $10M Was Paid Upon Execution Of Agreement And Remainder To Be Paid Next 12 Months; Eliminates $14M Accounts Payable Liability From Balance Sheet

CytoDyn Announces Submission Of Clinical Protocol To FDA And Initiation Of Pre-Clinical Study In Glioblastoma

Management

CytoDyn Appoints Jacob Lalezari As CEO, Effective Jan. 26, 2024; Mitchell Cohen Appointed Interim CFO, Effective Feb. 1, 2024

On December 14th, the Federal Reserve hiked its key interest rate by 50 basis points. This was the first deceleration in rate hike increases in 2022; between March and November 2022, the interest rate had jumped 25 basis points, 50 basis points and then 75 points four times in a row in between each Federal Reserve meeting.&nbsp;&nbsp;
In a summary of the Federal Open Market Committee (FOMC) meeting on January 4th, 2022, the committee indicated that &ldquo;A number of participants emphasized that it would be important to clearly communicate that a slowing in the pace of rate increases was not an indication of any weakening of the Committee&rsquo;s resolve to achieve its price-stability goal or a judgment that inflation was already on a persistent downward path.&rdquo;
In the meantime, OTC Markets Group Inc.&rsquo;s (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/otcm#OTCQX">OTCM</a>) markets reported a decline in total monthly volume compared to last month, recording $32.1 billion in December compared to the $36.3 billion in November. The regulated markets, however, saw a jump in trading volume in the OTCQB Venture Market.&nbsp;
<h3>A Dive Into The OTCQX Best Market&rsquo;s Most-Active List</h3>
The OTCQX Best Market recorded $5.1 billion in trading volume in December, a slight decrease from the $6.7 billion in trading volume in <a href="https://www.benzinga.com/markets/penny-stocks/22/12/30054783/otc-market-groups-most-active-list-in-november-a-dive-into-the-names-experiencing-volume-cha">November</a>.&nbsp;
The top three companies on OTCQX&rsquo;s Most-Active list experienced a slight reshuffle in December. Volume surged away from each of the top 3 contenders, but Roche Holding AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/rhhby#OTCQX">RHHBY</a>) claimed the top spot while crypto-centric securities Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>) and Grayscale Ethereum Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTCQX">ETHE</a>) slotted in at 2nd and 3rd place.&nbsp;
The remaining constituents in OTCQX&rsquo;s top 10 Most-Active securities list experienced change in December, welcoming Green Thumb Industries Inc. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gtbif#OTCQX">GTBIF</a>), Trulieve Cannabis Corporation (OTCQX:&nbsp; TCNNF) and Heineken N.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/heiny#OTCQX">HEINY</a>) in place of Deutsche Telekom AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/dtegy#OTCQX">DTEGY</a>), Computer Services Inc. and Zurich Insurance Group (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/zurvy#OTCQX">ZURVY</a>).
Computer Services was acquired and is no longer a publicly-listed company.&nbsp;
Other notable movers:
<ul>
<li>Wal-Mart De Mexico S.A.B. de C.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/wmmvy#OTCQX">WMMVY</a>) claimed the 16th spot on OTCQX&rsquo;s Most Active list, experiencing a 207% increase in trading volume.</li>
</ul>
<h3>The OTCQB Venture Market: A &ldquo;Battle&rdquo; For Top 10</h3>
The OTCQB Venture Market recorded $689.4 million in trading volume in December, a slight increase from the $652.4 million in trading volume in November.&nbsp;
Like the OTCQX Best Market, the OTCQB Venture Market&rsquo;s top 10 Most Active list for the month saw new entries. Specifically, CytoDyn Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTCQB">CYDY</a>) reappears in the top 10 Most Active list, bouncing back from its drop-off in November. Additionally, Renewable Innovations, Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/reii#OTCQB">REII</a>) (formerly NESTBUILDER.COM CORP. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/nbld#OTCQB">NBLD</a>)), a digital media and marketing services company, entered the top 10 Most Active list. The two displace Clean Vision Corporation (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/clnv#OTCQB">CLNV</a>) and Atlas Lithium Corporation (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/atlx#NASDAQ">ATLX</a>), both of which were on the list in November.&nbsp;
Other notable movers include:
<ul>
<li>American Lithium Corp. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/liacf#OTCQB">LIACF</a>), which climbed to 11th place on the Most Active list and recorded a $6.3 million rise in trading volume compared to last month.&nbsp;&nbsp;</li>
<li>Applied Energetics Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/aerg#OTCQB">AERG</a>), which climbed to 15th place on the Most Active list and recorded a $3.4 million rise in trading volume compared to last month.&nbsp;</li>
<li>Provectus Biopharmaceuticals, Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/pvct#OTCQB">PVCT</a>), which climbed to 28th place on the Most Active list and recorded a volume rise of $2.1 million compared to last month.&nbsp;</li>
</ul>
The OTCQX And OTCQB Top 10
Below are the top 10 most actively traded securities on the OTCQX Best Market and OTCQB Venture Market in December.&nbsp;
OTCQX Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
December Dollar Volume
</td>
</tr>
<tr>
<td>
Roche Holding Ltd.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/RHHBY/quote">RHHBY</a>
</td>
<td>
$938,518,331
</td>
</tr>
<tr>
<td>
Grayscale Bitcoin Trust (BTC)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GBTC/quote">GBTC</a>
</td>
<td>
$695,292,404
</td>
</tr>
<tr>
<td>
Grayscale Ethereum Trust (ETH)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ETHE/quote">ETHE</a>
</td>
<td>
$314,257,520
</td>
</tr>
<tr>
<td>
adidas AG
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ADDYY/quote">ADDYY</a>
</td>
<td>
$201,524,251
</td>
</tr>
<tr>
<td>
Green Thumb Industries Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GTBIF/quote">GTBIF</a>
</td>
<td>
$181,456,135
</td>
</tr>
<tr>
<td>
Infineon Technologies AG&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/IFNNY/quote">IFNNY</a>
</td>
<td>
$170,922,774
</td>
</tr>
<tr>
<td>
Danone
</td>
<td>
<a href="http://www.otcmarkets.com/stock/DANOY/quote">DANOY</a>
</td>
<td>
$138,268,039
</td>
</tr>
<tr>
<td>
Trulieve Cannabis Corporation
</td>
<td>
<a href="http://www.otcmarkets.com/stock/TCNNF/quote">TCNNF</a>
</td>
<td>
$128,114,184
</td>
</tr>
<tr>
<td>
Heineken N.V.
</td>
<td>
HEINY
</td>
<td>
$114,035,029
</td>
</tr>
<tr>
<td>
BNP Paribas&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/BNPQY/quote">BNPQY</a>
</td>
<td>
$113,842,833
</td>
</tr>
</tbody>
</table>
OTCQB Top 10:&nbsp;&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
December Dollar Volume
</td>
</tr>
<tr>
<td>
Vision Energy Corporation
</td>
<td>
VENG
</td>
<td>
$153,008,087
</td>
</tr>
<tr>
<td>
Northwest Biotherapeutics Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NWBO/quote">NWBO</a>
</td>
<td>
$46,999,760
</td>
</tr>
<tr>
<td>
Global Tech Industries Group Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GTII/quote">GTII</a>
</td>
<td>
$40,034,634
</td>
</tr>
<tr>
<td>
Fannie Mae&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/FNMA/quote">FNMA</a>
</td>
<td>
$21,525,480
</td>
</tr>
<tr>
<td>
CytoDyn Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CYDY/quote">CYDY</a>
</td>
<td>
$16,512,030
</td>
</tr>
<tr>
<td>
Netlist Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NLST/quote">NLST</a>
</td>
<td>
$16,467,857
</td>
</tr>
<tr>
<td>
Freddie Mac&nbsp;
</td>
<td>
<a href="https://www.otcmarkets.com/stock/FMCC/quote">FMCC</a>
</td>
<td>
$14,601,523
</td>
</tr>
<tr>
<td>
American Battery Technology Co.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ABML/quote">ABML</a>
</td>
<td>
$14,274,807
</td>
</tr>
<tr>
<td>
NESTBUILDER.COM CORP.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NBLD/quote">NBLD</a>
</td>
<td>
$11,538,861
</td>
</tr>
<tr>
<td>
CREATD INC.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CRTD/quote">CRTD</a>
</td>
<td>
$11,351,902
</td>
</tr>
</tbody>
</table>
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ZURVY

Trading Volume In The OTCQB Venture Market Picks Up in December – A Summary Of OTC Market Group's Most Active List In December

The SPDR S&amp;P 500 ETF Trust (NYSEARCA: SPY) increased by 5.56% in November, recording two subsequent monthly increases for the first time in 2022. The Fidelity NASDAQ Composite Index ETF (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/oneq#NASDAQ">ONEQ</a>) and the SPDR Dow Jones Industrial Average (DJA) ETF (NYSEARCA: DIA) mirrored this upward trend, showing monthly increases in October of 4.43% and 5.72%, respectively.&nbsp;
On November 2nd, the Federal Reserve hiked its key interest rate by 75 basis points, a figure congruent with expectations. The market dropped 2.51% on the day the news was released but closed roughly 6% higher than the day&rsquo;s close at the end of the month. While the Federal Reserve Chair Jerome Powell has not yet decreed a slow-down in interest rate hikes, Powell said a rate-hike slowdown is possible in December. The comment, issued on Nov. 30, caused the SPDR S&amp;P500 ETF Trust to rise by 3.15%.&nbsp;
In the meantime, OTC Markets Group Inc.&rsquo;s (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/otcm#OTCQX">OTCM</a>) markets maintained the total monthly volume from last month, recording $36.3 million in November. The regulated markets also saw a number of new entrants in both the OTCQX Best Market and OTCQB Venture Market.
<h3>A Dive Into The OTCQX Best Market&rsquo;s Most-Active List</h3>
The OTCQX Best Market recorded $6.7 billion in trading volume in November, a figure which has remained unchanged from <a href="https://www.benzinga.com/markets/penny-stocks/22/11/29700772/the-otcqb-venture-market-records-4-months-of-consecutive-volume-increases-in-otc-market-grou">October</a>.&nbsp;
The top three companies on OTCQX&rsquo;s Most-Active list experienced a slight reshuffle in November. Volume surged into crypto-centric securities Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>) and Grayscale Ethereum Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTCQX">ETHE</a>). The former doubled its trading volume in November, propelling it into first place on OTCQX&rsquo;s Most-Active list. Roche Holding AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/rhhby#OTCQX">RHHBY</a>) is now nestled between the two crypto giants on the list, securing second place.&nbsp;
The remaining constituents in OTCQX&rsquo;s top 10 Most-Active securities experienced a slight reshuffle in November, welcoming Zurich Insurance Group (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/zurvy#OTCQX">ZURVY</a>) and Danone (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/danoy#OTCQX">DANOY</a>) in place of Royal DSM NV and Anglo American plc (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/aaukf#OTCQX">AAUKF</a>) respectively.&nbsp;
Other notable movers:
&nbsp;
<ul>
<li aria-level="1">ASM International N.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/asmiy#OTCQX">ASMIY</a>) claimed the 17th spot on OTCQX&rsquo;s Most Active list, experiencing a 98% increase in trading volume.</li>
</ul>
<ul>
<li aria-level="1">JBS S.A. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/jbsay#OTCQX">JBSAY</a>) claimed the 27th spot on OTCQX&rsquo;s Most Active list, experiencing a 94% increase in trading volume.&nbsp;</li>
</ul>
<ul>
<li aria-level="1">Bombardier Inc. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/bdrbf#OTCQX">BDRBF</a>) claimed the 28th spot on OTCQX&rsquo;s Most Active list, experiencing a 203% increase in trading volume.</li>
</ul>
&nbsp;
<h3>The OTCQB Venture Market: New Faces&nbsp;</h3>
The OTCQB Venture Market recorded $652.4 million in trading volume in November, a slight decrease from the $739 million recorded in October.&nbsp;
Like the OTCQX Best Market, the OTCQB Venture Market&rsquo;s top 10 Most Active list for the month saw new entries. Specifically, CytoDyn Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTCQB">CYDY</a>), GPO PLUS INC. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/gpox#OTCQB">GPOX</a>) and Evofem Biosciences Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/evfm#OTCQB">EVFM</a>) made way for Vision Energy Corporation (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/vihdd#OTCQB">VIHDD</a>), Atlas Lithium Corporation (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/atlx#OTCQB">ATLX</a>) and Clean Vision Corporation (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/clnv#OTCQB">CLNV</a>)
The three new securities address different market segments. Vision Energy Corporation, for example, specializes in building hydrogen production facilities, while Evofem Biosciences is working on a hormone-free contraceptive for women. Atlas Lithium, as its name suggests, is a mineral exploration company with an emphasis on Lithium.&nbsp;
Other notable movers include:&nbsp;
<ul>
<li style="font-weight: 400;" aria-level="1">Fission 3.0 Corp (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/fisof#OTCQB">FISOF</a>), which climbed to 24th place on the Most Active list and recorded a $3 million rise in trading volume compared to last month.&nbsp;</li>
</ul>
&nbsp;
<ul>
<li aria-level="1">Crimson Wine Group Ltd. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cwgl#OTCQB">CWGL</a>), which climbed to 11th place on the Most Active list and recorded an $8.7 million rise in trading volume compared to last month.&nbsp;</li>
</ul>
<ul>
<li aria-level="1">CREATD INC. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/crtd#OTCQB">CRTD</a>), which climbed to 4th place on the Most Active list after jumping into the top-ten Most Active list just last month. The security recorded a volume rise of $40.9 million compared to last month.&nbsp;</li>
</ul>
&nbsp;
<h3>The OTCQX And OTCQB Top 10</h3>
Below are the top 10 most actively traded securities on the OTCQX Best Market and OTCQB Venture Market in November.&nbsp;
OTCQX Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
November Dollar Volume
</td>
</tr>
<tr>
<td>
Grayscale Bitcoin Trust (BTC)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GBTC/quote">GBTC</a>
</td>
<td>
$1,562,486,263
</td>
</tr>
<tr>
<td>
Roche Holding Ltd.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/RHHBY/quote">RHHBY</a>
</td>
<td>
$1,032,762,158
</td>
</tr>
<tr>
<td>
Grayscale Ethereum Trust (ETH)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ETHE/quote">ETHE</a>
</td>
<td>
$847,457,420
</td>
</tr>
<tr>
<td>
adidas AG
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ADDYY/quote">ADDYY</a>
</td>
<td>
$217,255,919
</td>
</tr>
<tr>
<td>
Infineon Technologies AG&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/IFNNY/quote">IFNNY</a>
</td>
<td>
$179,486,884
</td>
</tr>
<tr>
<td>
Deutsche Telekom AG
</td>
<td>
<a href="http://www.otcmarkets.com/stock/DTEGY/quote">DTEGY</a>
</td>
<td>
$140,536,398
</td>
</tr>
<tr>
<td>
BNP Paribas&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/BNPQY/quote">BNPQY</a>
</td>
<td>
$125,928,887
</td>
</tr>
<tr>
<td>
Danone
</td>
<td>
<a href="http://www.otcmarkets.com/stock/DANOY/quote">DANOY</a>
</td>
<td>
$120,417,109
</td>
</tr>
<tr>
<td>
Zurich Insurance Group Ltd.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ZURVY/quote">ZURVY</a>
</td>
<td>
$116,159,869
</td>
</tr>
<tr>
<td>
Computer Services Inc.
</td>
<td>
CSVI*
</td>
<td>
$114,096,120
</td>
</tr>
</tbody>
</table>
OTCQB Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
November Dollar Volume
</td>
</tr>
<tr>
<td>
Northwest Biotherapeutics Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NWBO/quote">NWBO</a>
</td>
<td>
$90,078,662
</td>
</tr>
<tr>
<td>
Global Tech Industries Group Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GTII/quote">GTII</a>
</td>
<td>
$76,149,779
</td>
</tr>
<tr>
<td>
Vision Energy Corporation
</td>
<td>
<a href="http://www.otcmarkets.com/stock/VIHDD/quote">VIHDD</a>
</td>
<td>
$61,129,362
</td>
</tr>
<tr>
<td>
CREATD INC.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CRTD/quote">CRTD</a>
</td>
<td>
$51,748,785
</td>
</tr>
<tr>
<td>
Netlist Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NLST/quote">NLST</a>
</td>
<td>
$25,488,642
</td>
</tr>
<tr>
<td>
Fannie Mae&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/FNMA/quote">FNMA</a>
</td>
<td>
$20,219,922
</td>
</tr>
<tr>
<td>
Freddie Mac&nbsp;
</td>
<td>
<a href="https://www.otcmarkets.com/stock/FMCC/quote">FMCC</a>
</td>
<td>
$14,847,731
</td>
</tr>
<tr>
<td>
Clean Vision Corporation
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CLNV/quote">CLNV</a>
</td>
<td>
$13,033,364
</td>
</tr>
<tr>
<td>
American Battery Technology Co.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ABML/quote">ABML</a>
</td>
<td>
$11,904,818
</td>
</tr>
<tr>
<td>
Atlas Lithium Corporation
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ATLX/quote">ATLX</a>
</td>
<td>
$10,449,901
</td>
</tr>
</tbody>
</table>
* Computer Services Inc. (CSVI) has since been <a href="https://www.csiweb.com/announcement/">acquired</a> and is no longer a publicly traded company&nbsp;
Featured Photo by <a href="https://unsplash.com/@juniorwebd">Roberto J&uacute;nior</a> on Unsplash
This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice.

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OTC Market Group's Most Active List In November: A Dive Into The Names Experiencing Volume Changes

The SPDR S&amp;P 500 ETF Trust (NYSEARCA: SPY) declined by 9.62% in September &ndash; its largest decline in 2022. The Fidelity NASDAQ Composite Index ETF (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/oneq#NASDAQ">ONEQ</a>) and the SPDR Dow Jones Industrial Average ETF (NYSEARCA: DIA) mimicked this downward trend, showing monthly decreases in September of 10.54% and 8.98%, respectively.
OTC Markets Group Inc.&rsquo;s (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/otcm#OTCQX">OTCM</a>) regulated markets experienced a slight increase in total monthly volume, recording $39.5 billion in September compared to $39.3 billion in August.&nbsp;
<h3>A Dive Into The OTCQX Best Market&rsquo;s Most-Active List</h3>
The OTCQX Best Market recorded $7.3 billion in trading volume in September, a slight increase over the $6.9 billion traded in <a href="https://www.benzinga.com/markets/penny-stocks/22/09/28827948/a-quick-look-at-the-otc-markets-most-active-securities-in-august-heres-what-you-need-to-know">August</a>.
Despite Ethereum&rsquo;s successful completion of the Merge, trading volume in Grayscale Ethereum Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTCQX">ETHE</a>) waned in September, dropping the security to third on the OTCQX Best Market&rsquo;s Most Active list. Steadfast performers Roche Holding AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/rhhby#OTCQX">RHHBY</a>) and Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>) slotted into first and second place, respectively.&nbsp;
Additionally, OTCQX&rsquo;s top 10 most-active securities experienced a slight reshuffle in September, welcoming previously familiar faces in Danone (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/danoy#OTCQX">DANOY</a>) and in Deutsche Telekom AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/dtegy#OTCQX">DTEGY</a>) and Akzo Nobel N.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/akzoy#OTCQX">AKZOY</a>). The three newcomers displace BASF SE (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/basfy#OTCQX">BASFY</a>), Anglo American PLC (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ngloy#OTCQX">NGLOY</a>) and Imperial Brands PLC (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/imbby#OTCQX">IMBBY</a>) in the top 10 most-active securities list.&nbsp;
Other notable movers:
<ul>
<li>J Sainsbury PLC (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/jsaiy#OTCQX">JSAIY</a>) claimed the 28th spot on the OTCQX&rsquo;s Most Active list, experiencing a 203% increase in trading volume.&nbsp;</li>
</ul>
<ul>
<li>Koninklijke Ahold Delhaize N.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/adrny#OTCQX">ADRNY</a>) claimed the 15th spot on the OTCQX&rsquo;s Most Active list, experiencing a 127% increase in trading volume.&nbsp;</li>
</ul>
&nbsp;
<h3>The OTCQB Venture Market Experiences A Reshuffle</h3>
The OTCQB Venture Market recorded $642.6 million in trading volume in September, an increase from both July&rsquo;s $463 million and August&rsquo;s $601 million trading volume figures.
Like the OTCQX Best Market, the OTCQB Venture Market&rsquo;s top 10 Most Active list for the month saw new entries. Specifically, Todos Medical Ltd. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/tomdf#OTCQB">TOMDF</a>) and American Lithium Corp. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/liacf#OTCQB">LIACF</a>) made way for Global Tech Industries Group Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/gtii#OTCQB">GTII</a>) and Know Labs Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/knwn#OTCQB">KNWN</a>).
Similar to August, the OTCQB Venture Market witnessed a number of novelties in September. In addition to two new companies on the top 10 Most Active List, the constituents of the list experienced a shakeup. Biotechnology company CytoDyn Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTCQB">CYDY</a>), for example, dropped from most traded to seventh-most traded security, while newcomer Global Tech Industries took a giant leap all the way to first place. Lithium miner Lake Resources N.L. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/llkkf#OTCQB">LLKKF</a>) experienced a similar jump, rising to second place from eighth place last month.&nbsp;
Other notable movers:&nbsp;
<ul>
<li>Silver Mountain Resources Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/agmrf#OTCQB">AGMRF</a>) climbed to 11th place on the Most Active list and recorded an $8.9 million rise in trading volume compared to last month.</li>
</ul>
&nbsp;
<ul>
<li>Know Labs Inc. climbed to 10th place on the Most Active list for the OTCQB Venture Market and recorded a $7.7 million rise in trading volume compared to last month.</li>
</ul>
<ul>
<li>BioLargo Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/blgo#OTCQB">BLGO</a>) climbed to 23rd place on the Most Active list and recorded a $2.3 million rise in trading volume compared to last month.</li>
</ul>
&nbsp;
The OTCQX And OTCQB Top 10
Below are the top 10 most actively traded securities on the OTCQX Best Market and OTCQB Venture Market in September.&nbsp;
OTCQX Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
September Dollar Volume
</td>
</tr>
<tr>
<td>
Roche Holding Ltd.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/RHHBY/quote">RHHBY</a>
</td>
<td>
$1,707,901,205
</td>
</tr>
<tr>
<td>
Grayscale Bitcoin Trust (BTC)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GBTC/quote">GBTC</a>
</td>
<td>
$785,442,416
</td>
</tr>
<tr>
<td>
Grayscale Ethereum Trust (ETH)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ETHE/quote">ETHE</a>
</td>
<td>
$685,952,488
</td>
</tr>
<tr>
<td>
adidas AG
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ADDYY/quote">ADDYY</a>
</td>
<td>
$317,175,529
</td>
</tr>
<tr>
<td>
BNP Paribas
</td>
<td>
<a href="http://www.otcmarkets.com/stock/BNPQY/quote">BNPQY</a>
</td>
<td>
$295,090,950
</td>
</tr>
<tr>
<td>
Deutsche Telekom AG
</td>
<td>
<a href="http://www.otcmarkets.com/stock/DTEGY/quote">DTEGY</a>
</td>
<td>
$268,213,144
</td>
</tr>
<tr>
<td>
Computer Services Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CSVI/quote">CSVI</a>
</td>
<td>
$216,708,362
</td>
</tr>
<tr>
<td>
Akzo Nobel N.V.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/AKZOY/quote">AKZOY</a>
</td>
<td>
$167,395,328
</td>
</tr>
<tr>
<td>
Danone
</td>
<td>
<a href="https://www.otcmarkets.com/stock/DANOY/quote">DANOY</a>
</td>
<td>
$167,340,096
</td>
</tr>
<tr>
<td>
Infineon Technologies AG&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/IFNNY/quote">IFNNY</a>
</td>
<td>
$158,503,975
</td>
</tr>
</tbody>
</table>
OTCQB Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
September Dollar Volume
</td>
</tr>
<tr>
<td>
Global Tech Industries Group Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GTII/quote">GTII</a>
</td>
<td>
$119,304,739
</td>
</tr>
<tr>
<td>
Lake Resources N.L.&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/LLKKF/quote">LLKKF</a>
</td>
<td>
$24,528,742
</td>
</tr>
<tr>
<td>
Stemtech Corp.
</td>
<td>
<a href="https://www.otcmarkets.com/stock/STEK/quote">STEK</a>
</td>
<td>
$22,459,406
</td>
</tr>
<tr>
<td>
Northwest Biotherapeutics Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NWBO/quote">NWBO</a>
</td>
<td>
$21,313,034
</td>
</tr>
<tr>
<td>
American Battery Technology Co.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ABML/quote">ABML</a>
</td>
<td>
$16,729,817
</td>
</tr>
<tr>
<td>
Fannie Mae&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/FNMA/quote">FNMA</a>
</td>
<td>
$15,086,158
</td>
</tr>
<tr>
<td>
CytoDyn Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CYDY/quote">CYDY</a>
</td>
<td>
$14,135,987
</td>
</tr>
<tr>
<td>
Netlist Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NLST/quote">NLST</a>
</td>
<td>
$13,413,921
</td>
</tr>
<tr>
<td>
Freddie Mac&nbsp;
</td>
<td>
<a href="https://www.otcmarkets.com/stock/FMCC/quote">FMCC</a>
</td>
<td>
$12,995,635
</td>
</tr>
<tr>
<td>
Know Labs Inc.&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/KNWN/quote">KNWN</a>
</td>
<td>
$10,652,167
</td>
</tr>
</tbody>
</table>
This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice.
Featured photo by Kelly Sikkema on <a href="https://unsplash.com/photos/zcAgxLryKe4">Unsplash</a>

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Most Active On The OTC Markets In September – A Look Back As October Comes To A Close

July gave world markets a breather from 2022&rsquo;s poor financial conditions.
The SPDR S&amp;P 500 ETF Trust (NYSEARCA: SPY) increased 9.21% in July, its highest monthly price ascension since November 2020. The Fidelity NASDAQ Composite Index ETF (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/oneq#NASDAQ">ONEQ</a>) and the SPDR Dow Jones Industrial Average ETF (NYSEARCA: DIA) displayed similar optimism, showing monthly increases of 12.51% and 6.78%, respectively, in July.
The market has reacted favorably to some recent developments, including The Federal Reserve&rsquo;s decision to maintain rather than increase interest rates as well as the release of this <a href="https://www.bls.gov/">report</a>, which reveals that 528,000 jobs have been added to the economy. Some expert traders, however, remain skeptical of July&rsquo;s bullish movement, noting the similarity of this rally to the one experienced in 2008. The latter was followed by a second wave of downward movement that stretched over months.
As ambiguity simmers surrounding market sentiment, OTC Markets Group Inc.&rsquo;s (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/otcm#OTCQX">OTCM</a>) regulated markets experienced a slight decrease in total monthly volume, recording $37.3 billion in July compared to $45.2 billion in June.
Despite the decrease, a number of new securities have emerged onto the OTCQX Best Market and OTCQB Venture Market, possibly demonstrating the ability to attract interest in a wide range of industries. Both the OTCQX Best Market and the OTCQB Venture Market maintained a significant international presence, with over half of the top most-traded securities across both markets composed of international operators.
<h3>A Dive Into The OTCQX Best Market&rsquo;s Most-Active List</h3>
The OTCQX Best Market recorded $7 billion in trading volume in July, a decrease from June&rsquo;s $9 billion.
Weathering the storm of decreasing volume are the OTCQX Best Market&rsquo;s steadfast volume performers Roche Holding AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/rhhby#OTCQX">RHHBY</a>), Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>) and Grayscale Ethereum Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTCQX">ETHE</a>). In July, Roche Holding reaped the most trading volume as opposed to Grayscale Bitcoin Trust, which took that spot in June.
Additionally, OTCQX&rsquo;s top 10 most-active securities experienced a slight reshuffle in July, welcoming BASF SE (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/basfy#OTCQX">BASFY</a>) and Zurich Insurance Group Inc. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/zurvy#OTCQX">ZURVY</a>) in place of Experian plc (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/expgy#OTCQX">EXPGY</a>) and Tesco PLC (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/tscdy#OTCQX">TSCDY</a>).
Despite decreasing month-on-month volume figures, the OTCQX Best Market has managed to maintain its hold on a number of industries, as demonstrated by the constituents of its Most Active list. Below are some of the companies and their relevant specialties:&nbsp;
<ul>
<li>Danone S.A. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/danoy#OTCQX">DANOY</a>): Healthcare.</li>
<li>Infineon Technologies AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ifnny#OTCQX">IFNNY</a>): Semiconductor solutions.</li>
<li>BASF SE (OTCQX: BASFY; BFFAF): Chemical manufacturing.&nbsp;</li>
<li>Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>): Cryptocurrency mining.</li>
<li>Trulieve Cannabis Corp. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/tcnnf#OTCQX">TCNNF</a>): Cannabis sales and cultivation.</li>
<li>Heineken N.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/heiny#OTCQX">HEINY</a>): Alcohol manufacturing and distribution.</li>
</ul>
Similar to June, 23 of the 30 Most Active constituents on the OTCQX Best Market were international operators. Some of these included new faces like Switzerland&rsquo;s Zurich Insurance Group and Germany&#39;s BASF SE, but regulars like Germany&rsquo;s Adidas AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/addyy#OTCQX">ADDYY</a>) and the United Kingdom&rsquo;s Anglo American PLC (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ngloy#OTCQX">NGLOY</a>) were also present.
Other notable movers:
<ul>
<li>Ayr Wellness Inc. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ayrwf#OTCQX">AYRWF</a>) claimed the No. 30 spot on the OTCQX&rsquo;s list of most-traded securities, experiencing a 150% change in trading volume from last month.</li>
</ul>
<h3>The OTCQB Venture Market Experiences A Reshuffle In July</h3>
The OTCQB Venture Market recorded $463 million in trading volume in July, a decline from June&rsquo;s $603 million figure.
July introduced several new entities to the OTCQB&rsquo;s Top 10 Most Active list. Stem-cell specialist Stemtech Corp. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/stek#OTCQB">STEK</a>) and mining operator Brazil Minerals Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/bmix#OTCQB">BMIX</a>) were among the new additions.
Similar to June, the OTCQB Venture Market witnessed a number of novelties in July. In addition to three new companies, all three of the most-traded securities in the market changed. June&rsquo;s OTCQB Most Active leaders Freddie Mac (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/fmcc#OTCQB">FMCC</a>) and Lake Resources (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/llkkf#OTCQB">LLKKF</a>) made way for biotech operator CytoDyn Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTCQB">CYDY</a>) and computer memory subsystems specialist Netlist Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/nlst#OTCQB">NLST</a>).
Thirteen international securities landed a spot on the OTCQB Venture Market&rsquo;s Most Active list. Of these 13, three are Australian, eight are Canadian, one is British and one is from Hong Kong.
Other notable movers:
<ul>
<li>Snowline Gold Corp. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/snwgf#OTCQB">SNWGF</a>) climbed to 15th place in the Most Active list and recorded a $3.8 million rise in trading volume compared to last month.&nbsp;</li>
<li>88 Energy Ltd. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/eeenf#OTCQB">EEENF</a>) climbed to 13th place in the Most Active list and recorded a $3.5 million rise in trading volume compared to last month.</li>
</ul>
The OTCQX And OTCQB Top 10
Below are the top 10 most actively traded securities on the OTCQX Best Market and OTCQB Venture Market in July.&nbsp;
OTCQX Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
July Dollar Volume
</td>
</tr>
<tr>
<td>
Roche Holding Ltd.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/RHHBY/quote">RHHBY</a>
</td>
<td>
$1,174,038,337
</td>
</tr>
<tr>
<td>
Grayscale Bitcoin Trust (BTC)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GBTC/quote">GBTC</a>
</td>
<td>
$1,171,194,870
</td>
</tr>
<tr>
<td>
Grayscale Ethereum Trust (ETH)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ETHE/quote">ETHE</a>
</td>
<td>
$824,696,740
</td>
</tr>
<tr>
<td>
adidas AG
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ADDYY/quote">ADDYY</a>
</td>
<td>
$242,545,358
</td>
</tr>
<tr>
<td>
Danone
</td>
<td>
<a href="https://www.otcmarkets.com/stock/DANOY/quote">DANOY</a>
</td>
<td>
$236,789,470
</td>
</tr>
<tr>
<td>
BNP Paribas
</td>
<td>
<a href="http://www.otcmarkets.com/stock/BNPQY/quote">BNPQY</a>
</td>
<td>
$221,832,673
</td>
</tr>
<tr>
<td>
Infineon Technologies AG&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/IFNNY/quote">IFNNY</a>
</td>
<td>
$155,256,947
</td>
</tr>
<tr>
<td>
BASF SE
</td>
<td>
<a href="https://www.otcmarkets.com/stock/BASFY/quote">BASFY</a>
</td>
<td>
$133,635,750
</td>
</tr>
<tr>
<td>
Anglo American plc
</td>
<td>
<a href="https://www.otcmarkets.com/stock/NGLOY/quote">NGLOY</a>
</td>
<td>
$129,304,530
</td>
</tr>
<tr>
<td>
Zurich Insurance Group Ltd.
</td>
<td>
<a href="https://www.otcmarkets.com/stock/ZURVY/quote">ZURVY</a>
</td>
<td>
$125,075,924
</td>
</tr>
</tbody>
</table>
OTCQB Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
July Dollar Volume
</td>
</tr>
<tr>
<td>
CytoDyn Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CYDY/quote">CYDY</a>
</td>
<td>
$37,078,914
</td>
</tr>
<tr>
<td>
Netlist Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NLST/quote">NLST</a>
</td>
<td>
$34,113,360
</td>
</tr>
<tr>
<td>
Freddie Mac&nbsp;
</td>
<td>
<a href="https://www.otcmarkets.com/stock/FMCC/quote">FMCC</a>
</td>
<td>
$30,241,752
</td>
</tr>
<tr>
<td>
Fannie Mae&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/FNMA/quote">FNMA</a>
</td>
<td>
$27,396,005
</td>
</tr>
<tr>
<td>
Northwest Biotherapeutics Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NWBO/quote">NWBO</a>
</td>
<td>
$22,674,446
</td>
</tr>
<tr>
<td>
American Battery Technology Co.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ABML/quote">ABML</a>
</td>
<td>
$16,153,987
</td>
</tr>
<tr>
<td>
Humbl Inc.
</td>
<td>
<a href="https://www.otcmarkets.com/stock/HMBL/quote">HMBL</a>
</td>
<td>
$14,817,569
</td>
</tr>
<tr>
<td>
Stemtech Corp.
</td>
<td>
<a href="https://www.otcmarkets.com/stock/STEK/quote">STEK</a>
</td>
<td>
$12,940,312
</td>
</tr>
<tr>
<td>
Lake Resources N.L.&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/LLKKF/quote">LLKKF</a>
</td>
<td>
$11,131,503
</td>
</tr>
<tr>
<td>
Brazil Minerals Inc.
</td>
<td>
<a href="https://www.otcmarkets.com/stock/BMIX/quote">BMIX</a>
</td>
<td>
$7,447,947
</td>
</tr>
</tbody>
</table>
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OTC Markets' Most Active Securities Sees A Shake-up In July

The month of July saw $37.3 billion in trading volume for stocks that trade on the OTCQK and OTCQB. While some of the stocks that trade over-the-counter are considered&nbsp;<a href="https://www.benzinga.com/best-penny-stocks">penny stocks</a> based on their share price, they are also some of the largest companies in the world and represent a diverse list of sectors.
The total in July was down from $45.2 million in June, as <a href="https://www.benzinga.com/markets/cryptocurrency/22/07/27971151/these-were-the-most-traded-otc-stocks-in-june-where-do-danone-adidas-and-grayscale-bitcoin">reported </a>by Benzinga.
Here were the top 10 traded stocks in July on the OTC by trading volume:
1. Roche Holdings&nbsp;(OTC: <a class="ticker" href="https://www.benzinga.com/stock/rhhby#OTC">RHHBY</a>)
Volume: $1.17 billion
June Rank: #2
52-Week Price Range: $37.88 to $53.86
Current Price: $41.23
What the Company Does: One of the largest biotechnology companies in the world, Roche operates across several lines of the healthcare industry including pharmaceutical products, oncology therapies, diagnostics and oncology products. The Swiss company has a market capitalization of more than&nbsp;$250 billion.
2. Grayscale Bitcoin Trust (OTC: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTC">GBTC</a>)
Volume: $1.17 billion
June Rank: #1
52-Week Price Range: $11.92 to $55.05
Current Price: $14.21
What the Company Does: Launched in 2013, the Grayscale Bitcoin Trust offers investors a way to gain exposure to Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) without the challenges of buying and storing the cryptocurrency.
3. Grayscale Ethereum Trust (OTC: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTC">ETHE</a>)
Volume: $824.7 million
June Rank: #3
52-Week Price Range: $6.85 to $47.40
Current Price: $12.14
What the Company Does: Launched in 2017, the Grayscale Ethereum Trust was one of the first securities that were solely invested in the price of Ethereum (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/eth/usd">ETH</a>). Investors get exposure to Ethereum as a security and pay a premium to not have to worry about buying and keeping the cryptocurrency safe on their own.
4. Adidas AG (OTC: <a class="ticker" href="https://www.benzinga.com/stock/addyy#OTC">ADDYY</a>)
Volume: $242.5 million
June Rank: #6
52-Week Price Range: $76.70 to $199.44
Current Price: $87.61
What the Company Does: Competing with Nike Inc (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/nke#NYSE">NKE</a>) and Under Armour (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/ua#NYSE">UA</a>)(NYSE: <a class="ticker" href="https://www.benzinga.com/stock/uaa#NYSE">UAA</a>), Adidas is one of the largest apparel and footwear companies in the world. The company has grown its exposure to new audiences recently with its Kanye West partnership for the Yeezy brand and a partnership with NFT collections Bored Ape Yacht Club and PUNKS Comics. Adidas moved up two places in the top 10&nbsp;in July and saw its share price rise.
5. Danone (OTC: <a class="ticker" href="https://www.benzinga.com/stock/danoy#OTC">DANOY</a>)
Volume: $236.8 million
June Rank: #4
52-Week Price Range: $10.21 to $15.38
Current Price: $10.99
What the Company Does: Danone is well known as one of the largest dairy and infant nutrition companies in the world. The company&rsquo;s three operating segments are dairy and plant-based products, specialized nutrition and bottled water.
Related Link: <a href="https://www.benzinga.com/money/how-to-buy-otc-stocks">How To Buy OTC Stocks</a>
6. BNP Paribas (OTC: <a class="ticker" href="https://www.benzinga.com/stock/bnpqy#OTC">BNPQY</a>)
Volume: $221.8 million
June Rank: #5
52-Week Price Range: $20.36 to $38.48
Current Price: $25.08
What the Company Does: BNP Paribas is one of the largest banks in France and has operations in around 80 countries around the world.
7. Infineon Technologies (OTC: <a class="ticker" href="https://www.benzinga.com/stock/ifnny#OTC">IFNNY</a>)
Volume: $155.3 million
June Rank: #7
52-Week Price Range: $21.49 to $49.99
Current Price: $28.42
What the Company Does: European chipmaker Infineon Technologies was spun off of Siemens AG (OTC: <a class="ticker" href="https://www.benzinga.com/stock/siegy#OTC">SIEGY</a>) in 2000. The company produces automotive semiconductors used for safety and powertrain segments of the auto industry. The stock held steady in seventh place and saw its share price rise in July.
8. BASF SE (OTC: <a class="ticker" href="https://www.benzinga.com/stock/basfy#OTC">BASFY</a>)
Volume: $133.6 million
June Rank: Not in top 10
52-Week Price Range: $9.99 to $20.50
Current Price: $11.30
What the Company Does: One of two newcomers to the top 10&nbsp;volume leaders in July, BASF is the world&rsquo;s largest chemical company. The company is a large player in specialty chemicals and agricultural crop protection.
9. Anglo American PLC (OTC: <a class="ticker" href="https://www.benzinga.com/stock/ngloy#OTC">NGLOY</a>)
Volume: $129.3 million
June Rank: #9
52-Week Price Range: $14.76 to $27.80
Current Price: $17.54
What the Company Does: Anglo American is one of the largest mining companies operating commodities such as copper, coal, iron ore and platinum. The company is one of the largest platinum miners in the world and also among the largest palladium miners. Anglo also owns 85% of De Beers, one of the largest diamond suppliers in the world.
10. Zurich Insurance Group (OTC: <a class="ticker" href="https://www.benzinga.com/stock/zurvy#OTC">ZURVY</a>)
Volume: $125.1 million
June Rank: Not in top 10
52-Week Price Range: $41.20 to $49.95
Current Price: $43.84
What the Company Does: Insurance company Zurich operates with three main segments of general insurance, life insurance and Farmers Management Services.
For the OTCQB, these were the five stocks with the most volume in July:
CytoDyn Inc (OTC: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTC">CYDY</a>): $37.1 million
Netlist, Inc. (OTC: <a class="ticker" href="https://www.benzinga.com/stock/nlst#OTC">NLST</a>): $34.1 million
Freddie Mac (OTC: <a class="ticker" href="https://www.benzinga.com/stock/fmcc#OTC">FMCC</a>): $30.2 million
Fannie Mae (OTC: <a class="ticker" href="https://www.benzinga.com/stock/fnma#OTC">FNMA</a>) $27.4 million
Northwest Biotherapeutics, Inc (OTC: <a class="ticker" href="https://www.benzinga.com/stock/nwbo#OTC">NWBO</a>): $22.7 billion
Photo:&nbsp;<a href="https://www.shutterstock.com/g/aleksandrsmuiznieks">Aleksandrs Muiznieks</a>&nbsp;via Shutterstock
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These 2 Under-The-Radar Stocks Traded More Than $1B Each Last Month

Reflecting the expected conditions of a bear market, many of the world&rsquo;s indices saw a decrease in price throughout June.
The SPDR S&amp;P 500 ETF Trust (NYSEARCA: SPY), for example, declined 8.26% in June, a very similar decline to the one seen in April. The SPY&rsquo;s maximum decline since its peak in January is 24%, falling within the standard definition of a bear market.&nbsp;
The Fidelity NASDAQ Composite Index ETF (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/oneq#NASDAQ">ONEQ</a>) and the SPDR Dow Jones Industrial Average ETF (NYSEARCA: DIA) displayed similar weakness, showing declines of 8.7% and 6.78%, respectively, in June.
Despite the decline in market indices and exchange-traded funds (ETFs), OTC Markets Group Inc.&rsquo;s (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/otcm#OTCQX">OTCM</a>) regulated markets experienced a slight increase in total monthly dollar volume, recording $45.2 billion in June compared to $44.5 billion in May. Additionally, the operator saw former cryptocurrency and mortgage financiers return to the helm of the Most Actively Traded Securities list on two of its regulated markets.&nbsp;
Both the OTCQX Best Market and the OTCQB Venture Market maintained a significant international presence, with over half of the top most-traded securities across both markets composed of international operators.
<h3>Crypto Reclaims The Helm Of The OTCQX Best Market Most-Active Securities&nbsp;</h3>
The OTCQX Best Market recorded $9 billion in trading volume in June, a decrease from May&rsquo;s $11 billion.&nbsp;
Despite the decrease in volume, former leaders have begun to reclaim their place among the Most Active Securities list. Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>), for example, has reclaimed its spot as the most-traded security on the OTCQX Best Market, followed by May&rsquo;s leader Roche Holding AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/rhhby#OTCQX">RHHBY</a>) and Grayscale Ethereum Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTCQX">ETHE</a>).&nbsp;
Additionally, the OTCQX&rsquo;s top 10 most-active securities experienced a slight reshuffle in June, welcoming&nbsp;
Experian PLC (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/expgy#OTCQX">EXPGY</a>) and Tesco PLC (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/tscdy#OTCQX">TSCDY</a>) in place of AXA SA (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/axahy#OTCQX">AXAHY</a>) and Sprott Physical Uranium Trust Fund (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/sruuf#OTCQX">SRUUF</a>).
International operators, once again, maintained a strong presence on OTCQX, comprising 23 of the top 30 securities, down from 24 in May. France&rsquo;s BNP Paribas SA (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/bnpqy#OTCQX">BNPQY</a>) and Germany&rsquo;s Infineon Technologies AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ifnny#OTCQX">IFNNY</a>) and adidas AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/addyy#OTCQX">ADDYY</a>) were again on the OTCQX top 10 most-active securities, while Mexico&rsquo;s Wal-Mart De Mexico S.A.B. de C.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/wmmvy#OTCQX">WMMVY</a>) and Australia&rsquo;s Fortescue Metals Group Ltd. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/fsugy#OTCQX">FSUGY</a>) made it among June&rsquo;s top 30 most-active securities.
Other notable movers:
&nbsp;
<ul>
<li>Danone (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/danoy#OTCQX">DANOY</a>) claimed fourth place on the OTCQX&rsquo;s list of most-traded securities, experiencing a 160% change in trading volume from last month.</li>
</ul>
&nbsp;
<h3>The OTCQB Venture Market Welcomes Back Mortgage Financiers</h3>
The OTCQB Venture Market recorded $603 million in trading volume in June, a decline from May&rsquo;s $896 million figure.
June introduced two new entities to the OTCQB&rsquo;s Top 10 Most-Traded Securities list. Biotech operator CytoDyn Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTCQB">CYDY</a>) and aerospace and defense company Applied Energetics Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/aerg#OTCQB">AERG</a>) represent the new faces on the list.
Similar to May, the OTCQB Venture Market witnessed a number of novelties in June. In addition to two new companies, all three of the top most-traded securities in the market changed. Mortgage financiers Fannie Mae (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/fnma#OTCQB">FNMA</a>) and Freddie Mac (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/fmcc#OTCQB">FMCC</a>) reclaimed their positions as the first- and third-most traded securities and Lake Resources (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/llkkf#OTCQB">LLKKF</a>) claimed its spot as the second most-traded security.
All three former &ldquo;Most Active Top 3s&rdquo; &ndash; Northwest Biotherapeutics Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/nwbo#OTCQB">NWBO</a>), Sysorex Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/sysx#OTCQB">SYSX</a>) and Netlist Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/nlst#OTCQB">NLST</a>) &ndash; remain on the OTCQB&rsquo;s Venture Market Top 10 Most Active Securities list, potentially hinting at sustained investor interest.
Twelve international securities landed a spot among the top 30 most-traded securities. Of these 12 securities, eight are Canadian, two are Australian, one is English, and one is from Hong Kong.&nbsp;
Other notable movers:&nbsp;
<ul>
<li>Wiki Soft Corp. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/wsft#OTCQB">WSFT</a>) climbed to 12th place in the most-active group and recorded a $6.6 million rise in trading volume compared to last month.&nbsp;</li>
</ul>
&nbsp;
<ul>
<li>Sharing Economy International Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/seii#OTCQB">SEII</a>) experienced a $3.7 million increase in trading volume compared to May, climbing to 19th place on the OTCQB&rsquo;s Top 30.&nbsp;</li>
</ul>
&nbsp;
The OTCQX And OTCQB Top 10
Below are the top 10 most actively traded securities on the OTCQX Best Market and OTCQB Venture Market in June.&nbsp;
OTCQX Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
June Dollar Volume
</td>
</tr>
<tr>
<td>
Grayscale Bitcoin Trust (BTC)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/GBTC/quote">GBTC</a>
</td>
<td>
$2,598,254,251
</td>
</tr>
<tr>
<td>
Roche Holding Ltd.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/RHHBY/quote">RHHBY</a>
</td>
<td>
$1,382,600,575
</td>
</tr>
<tr>
<td>
Grayscale Ethereum Trust (ETH)
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ETHE/quote">ETHE</a>
</td>
<td>
$976,746,377
</td>
</tr>
<tr>
<td>
Danone
</td>
<td>
<a href="https://www.otcmarkets.com/stock/DANOY/quote">DANOY</a>
</td>
<td>
$313,801,324
</td>
</tr>
<tr>
<td>
BNP Paribas
</td>
<td>
<a href="http://www.otcmarkets.com/stock/BNPQY/quote">BNPQY</a>
</td>
<td>
$298,306,543
</td>
</tr>
<tr>
<td>
adidas AG
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ADDYY/quote">ADDYY</a>
</td>
<td>
$287,277,517
</td>
</tr>
<tr>
<td>
Infineon Technologies AG&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/IFNNY/quote">IFNNY</a>
</td>
<td>
$165,504,013
</td>
</tr>
<tr>
<td>
Experian plc
</td>
<td>
<a href="http://www.otcmarkets.com/stock/EXPGY/quote">EXPGY</a>
</td>
<td>
$164,324,697
</td>
</tr>
<tr>
<td>
Anglo American plc
</td>
<td>
<a href="https://www.otcmarkets.com/stock/NGLOY/quote">NGLOY</a>
</td>
<td>
$141,723,690
</td>
</tr>
<tr>
<td>
Tesco PLC
</td>
<td>
<a href="http://www.otcmarkets.com/stock/TSCDY/quote">TSCDY</a>
</td>
<td>
$135,566,090
</td>
</tr>
</tbody>
</table>
OTCQB Top 10:&nbsp;
<table>
<tbody>
<tr>
<td>
Company Name
</td>
<td>
Symbol
</td>
<td>
June Dollar Volume
</td>
</tr>
<tr>
<td>
Fannie Mae&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/FNMA/quote">FNMA</a>
</td>
<td>
$45,002,762
</td>
</tr>
<tr>
<td>
Lake Resources N.L.&nbsp;
</td>
<td>
<a href="http://www.otcmarkets.com/stock/LLKKF/quote">LLKKF</a>
</td>
<td>
$40,313,559
</td>
</tr>
<tr>
<td>
Freddie Mac&nbsp;
</td>
<td>
<a href="https://www.otcmarkets.com/stock/FMCC/quote">FMCC</a>
</td>
<td>
$27,312,021
</td>
</tr>
<tr>
<td>
Netlist Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NLST/quote">NLST</a>
</td>
<td>
$26,970,708
</td>
</tr>
<tr>
<td>
American Battery Technology Co.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/ABML/quote">ABML</a>
</td>
<td>
$25,756,627
</td>
</tr>
<tr>
<td>
Northwest Biotherapeutics Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/NWBO/quote">NWBO</a>
</td>
<td>
$24,033,013
</td>
</tr>
<tr>
<td>
Sysorex Inc.
</td>
<td>
<a href="https://www.otcmarkets.com/stock/SYSX/quote">SYSX</a>
</td>
<td>
$18,453,146
</td>
</tr>
<tr>
<td>
CytoDyn Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/CYDY/quote">CYDY</a>
</td>
<td>
$12,583,808
</td>
</tr>
<tr>
<td>
American Lithium Corp.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/LIACF/quote">LIACF</a>
</td>
<td>
$10,964,858
</td>
</tr>
<tr>
<td>
Applied Energetics Inc.
</td>
<td>
<a href="http://www.otcmarkets.com/stock/AERG/quote">AERG</a>
</td>
<td>
$8,948,024
</td>
</tr>
</tbody>
</table>
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Mortgage Financiers & Crypto Securities Reclaim Their Spots As Most Actively Traded Securities On OTC Markets In June

Here&#39;s a roundup of top developments in the biotech space over the last 24 hours:
<h3>Stocks In Focus</h3>
<h3>Amylyx Says FDA Committee Casts Negative Vote On ALS Drug</h3>
Amylyx Pharmaceuticals, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/amlx#NASDAQ">AMLX</a>) said Food and Drug Administration&#39;s Peripheral and Central Nervous System Drugs Advisory Committee, which reviewed its new drug application for AMX0035 for the treatment of amyotrophic lateral sclerosis, voted that the results from the Phase 2 study did not support the effectiveness of the treatment in ALS patients.
Although the FDA considers the recommendations of its advisory committees, the recommendations by the panel are non-binding. The AMX0035 NDA has a PDUFA action date of June 29.
Separately, the company reported full-year results showing lower revenues and a wider loss.
<h3>CytoDyn Announces Imposition Of Partial Hold On HIV Program, Full Clinical Hold On COVID Study</h3>
CytoDyn Inc. (OTC: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTC">CYDY</a>) said the FDA has placed a partial clinical hold on its HIV program and a full clinical hold on its COVID-19 program in the U.S. The company also said it elected to pause its Brazil COVID-19 trials pending results from its previously scheduled data safety monitoring committee meeting and is in the process of reevaluating the timing of its HIV biologic license resubmission.
<h3>Gilead&#39;s Partner Submits Regulatory Application For Trodelvy In Advanced Breast Cancer In Hong Kong</h3>
Hong Kong-listed Biopharma Everest Medicines said it has submitted a NDA to the Department of Health, the Hong Kong Special Administrative Region, China for Gilead Sciences, Inc.&#39;s (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/gild#NASDAQ">GILD</a>)&nbsp;<a href="&lt;br /&gt;https://www.benzinga.com/general/biotech/21/11/24254332/gileads-trodelvy-approved-in-europe-for-aggressive-form-of-breast-cancer">Trodelvy </a> for the treatment of unresectable locally advanced or metastatic triple-negative breast cancer in adult patients who have received two or more prior systemic therapies, with at least one of them being for metastatic disease.
Related Link: <a href="https://www.benzinga.com/general/biotech/22/03/26313832/the-week-ahead-in-biotech-march-27-april-2-lipocine-akebia-merck-await-fda-verdicts-adcom-test-fo">The Week Ahead In Biotech (March 27-April 2): Lipocine, Akebia, Merck Await FDA Verdicts, Adcom Test For Amylyx, BioNTech Earnings And More </a>
<h3>Clovis Announces Positive Phase 3 Data For Rubraca In Ovarian Cancer</h3>
Clovis Oncology, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/clvs#NASDAQ">CLVS</a>) announced positive top-line data from the monotherapy arm of the Phase 3 ATHENA trial demonstrating that Rubraca as a maintenance treatment successfully achieved the primary endpoint of significantly improved investigator-assessed progression-free survival compared with placebo.
Based on these results, the company said it plans to submit a supplemental NDA to the U.S. FDA during the second quarter of 2022 followed by a Type II Variation to the EMA during the third quarter of 2022 for a first-line maintenance treatment indication for women with advanced ovarian cancer regardless of biomarker status who have responded to first-line platinum-based chemotherapy. 
The stock was jumping 54% to $2.54 in premarket trading.
<h3>Novavax Files For Expanding Authorization Of COVID-19 Vaccine To Treat Adolescents In Europe</h3>
Novavax, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/nvax#NASDAQ">NVAX</a>) said it has submitted a request to expand the conditional marketing authorization of <a href="https://www.benzinga.com/general/biotech/21/12/24702181/novavaxs-covid-19-vaccine-scores-conditional-approval-in-europe">Nuvaxovid COVID-19 vaccine </a> in the European Union for adolescents age 12-17.&nbsp;
The stock was moving up 1.81% to $76.10 in premarket trading.
<h3>Masimo Warns Of Q1 Revenue Shortfall Due to Supply Chain Issues</h3>
Masimo Corporation (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/masi#NASDAQ">MASI</a>) said it expects product revenue for the first quarter of 2022 to fall in the range of $285 million-$315 million. Shortages of critical components in combination with other supply chain issues, including freight carrier delays, have led to lower-than-expected sales in the first quarter, according to the company.&nbsp;
The stock was slipping 8.82% to $141.70 in premarket trading.
<h3>Mainz Biomed Receives Positive Feedback On Design For Potential Pivotal Study Of Colorectal Cancer Detection Test</h3>
Mainz Biomed N.V. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/mynz#NASDAQ">MYNZ</a>) said it has received supportive feedback from the U.S. FDA on its pre-submission package profiling the potential pivotal clinical trial design for ColoAlert, its easy-to-use detection test for colorectal cancer. The company also announced the formal commencement of its reimbursement process for ColoAlert by scheduling an initial meeting with the Centers for Medicare and Medicaid Services in April 2022.
The stock was gaining 7.3% to $16.17 in premarket trading.
<h3>Jaguar Health Announces Crofelemer Distribution, Commercialization Deal For Select Middle East Countries</h3>
Jaguar, Heath, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/jagx#NASDAQ">JAGX</a>) said it has entered an agreement with Quadri Pharmaceuticals that grants Quadri Pharma exclusive promotional, commercialization, and distribution rights for specified human indications of crofelemer in Bahrain, Kuwait, Qatar, Saudi Arabia, the United Arab Emirates and Oman following regulatory approval to market Crofelemer in these countries for the specified indications.
The stock was rallying 16% to 62&nbsp;cents in premarket trading.
Click <a href="https://www.benzinga.com/fda-biotech#historical"> here </a> to access Benzinga&#39;s FDA calendar.
<h3>Earnings</h3>
EDAP TMS SA&nbsp;(NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/edap#NASDAQ">EDAP</a>) reported lower fourth-quarter revenues but its earnings per share exceeded expectations.
The stock was adding 9.72% to $7.90 in premarket trading.
Acutus Medical, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/afib#NASDAQ">AFIB</a>) reported a year-over-year increase in fourth-quarter revenues but the loss per share was wider than expected. The company also issued below-consensus revenue guidance for the first quarter.
The stock was retreating 9.84% to $1.74 in premarket trading.
Clarus Therapeutics Holding Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/crxt#NASDAQ">CRXT</a>) reported higher revenues and a narrower-than-expected loss for the fourth quarter.
In premarket trading, the stock was plunging 20% to $1.66.
<h3>On The Radar</h3>
<h3>Earnings</h3>
<ul>
<li>Taysha Gene Therapies, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/tsha#NASDAQ">TSHA</a>) (before the market open)</li>
<li>PDS Biotechnology Corporation (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/pdsb#NASDAQ">PDSB</a>) (before the market open)</li>
<li>Affimed N.V. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/afmd#NASDAQ">AFMD</a>) (before the market open)</li>
<li>Adamis Pharmaceuticals Corporation ADMP) (after the close)</li>
<li>INVO Bioscience, Inc. INVO) (after the close)</li>
<li>Calithera Biosciences, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/cala#NASDAQ">CALA</a>) (after the close)</li>
<li>Inhibikase Therapeutics, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/ikt#NASDAQ">IKT</a>) (after the close)</li>
<li>Spero Therapeutics, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/spro#NASDAQ">SPRO</a>) (after the close)</li>
<li>Biocept, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/bioc#NASDAQ">BIOC</a>)</li>
</ul>
Related Link: <a href="https://www.benzinga.com/general/biotech/22/03/26260100/merck-continues-to-see-executive-exodus-heres-a-look-at-all-recent-departures"> Merck Continues to See Executive Exodus; Here&#39;s A Look At All Recent Departures </a>

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The Daily Biotech Pulse: Amylyx Announces Negative Adcom Vote, Clovis Jumps On Ovarian Cancer Data, Masimo Warns Of Q1 Shortfall

Photo from Jason Briscoe on <a href="https://unsplash.com/photos/Gw_sFen8VhU">Unsplash</a>
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Following news of high inflation, the SPDR S&amp;P500 (NYSEARCA: SPY) moved from a high of $478 to a low of $420.76. This move marked the first market correction &ndash; a decline of over 10% &ndash; since the COVID-19 pandemic emerged in <a href="https://www.usbank.com/investing/financial-perspectives/market-news/is-a-market-correction-coming.html#:~:text=The%20U.S.%20stock%20market%20has,occurred%20periodically%20through%20the%20years.">2020</a>. According to Ned Davis Research, a securities market research shop, this move indicated the worst-ever start of the year for the SPDR S&amp;P500. Other leading indices like the Dow Jones Industrial Average and the Nasdaq experienced similarly weak starts to the year.
Despite the shaky start to the year for markets, OTC Markets Group Inc. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/otcm#OTCQX">OTCM</a>) recorded a monthly total dollar volume of $53,023,723,310 across its markets.
<h3>International Presence</h3>
On the OTCQX &ndash; the OTC Markets&rsquo; top-tier&nbsp; &ndash; international operators experienced a percentage increase in trading volume relative to December. Notably, Roche Holdings AG (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/rhhby#OTCQX">RHHBY</a>), Infineon Technologies AG (OTQX: IFNNY), and BNP Paribas (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/bnpqy#OTCQX">BNPQY</a>) experienced 87%, 94%, and 61% increases in trading volume compared to December respectively.
Of the 20 securities with the most volume on the OTCQX and OTCQB in January, more than half of them were international operators. Sprott Physical Uranium TR (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/sruuf#OTCQB">SRUUF</a>), American Lithium Corp. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/liacf#OTCQB">LIACF</a>), and Tokens.com (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/smurf#OTCQB">SMURF</a>) constitute some of Canada&rsquo;s significant presence on the OTCQB&rsquo;s top 20, joined by Australia&rsquo;s 88 Energy Ltd. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/eeenf#OTCQB">EEENF</a>) and Lake Resource N.L. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/llkkf#OTCQB">LLKKF</a>) and Israel&#39;s Todos Medical Ltd. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/tomdf#OTCQB">TOMDF</a>). Notably, both Sprott and Carbon Streaming Corp. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/ofstf#OTCQB">OFSTF</a>) closed above $10 on the OTCQB. Also, the cryptocurrency, energy, and medical industries all feature in OTCQB&rsquo;s top 20, possibly showcasing the market&rsquo;s ability to sustain interest in a wide variety of verticals.&nbsp;
<h3>Volume Profile</h3>
Of the 20 securities with the most volume, Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>) and Grayscale Ethereum Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTCQX">ETHE</a>) maintained their hold on traders&rsquo; interest, securing first and second place despite cryptocurrency&rsquo;s January decline. Representing a shuffle from last month&rsquo;s leaders, Sprott and CytoDyn Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTCQB">CYDY</a>) lay claim to second and third place on the OTCQB&rsquo;s list of 20 most traded securities, ushering out previous long-standing contenders Fannie Mae (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/fnma#OTCQB">FNMA</a>) and Freddie Mac (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/fmcc#OTCQB">FMCC</a>).&nbsp;
<h2>The Top 10s</h2>
Below are the top 10 most actively traded securities on the OTCQX and OTCQB markets in January.&nbsp;
OTCQX Top 10:
<img alt="screenshot_2022-02-14_at_4.42.43_pm.png" src="https://www.benzinga.com/files/images/2022/February/14/screenshot_2022-02-14_at_4.42.43_pm.png" style="height:262px; width:650px" />
OTCQB Top 10:&nbsp;
<img alt="screenshot_2022-02-14_at_4.43.22_pm.png" src="https://www.benzinga.com/files/images/2022/February/14/screenshot_2022-02-14_at_4.43.22_pm.png" style="height:305px; width:650px" />
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These OTC Securities Reported The Most Trading Volume In January – With Possible Sustained Interest In International Operators

CytoDyn previously hit a primary endpoint in a pivotal Phase 3 HIV trial with some HTE patients; over 20 patients remain in an extension arm study for up to 4 years
CytoDyn will include some findings from this study in its BLA submission for HIV approval
CytoDyn Inc. (OTCQB:<a class="ticker" href="https://www.benzinga.com/stock/CYDY#OTCQB">CYDY</a>) (&quot;CytoDyn&quot; or the &quot;Company&quot;), a late-stage biotechnology company developing leronlimab, a CCR5 antagonist with the potential for multiple therapeutic indications, today announced that a research paper entitled &quot;Leronlimab (PRO 140) activity against 4-class drug resistant HIV-1 from Heavily Treatment Experienced Subjects&quot; has been accepted, peer reviewed and is available as a journal pre-proof on ScienceDirect. ScienceDirect provides access to a large bibliographic database of scientific and medical publications of the Dutch publisher Elsevier. This article is available for purchase from Elsevier through a link on CytoDyn&#39;s website:
<a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fabs%2Fpii%2FS1043661822000093%23%21&amp;esheet=52559969&amp;newsitemid=20220110005384&amp;lan=en-US&amp;anchor=LERONLIMAB+%28PRO+140%29+ACTIVITY+AGAINST+4-CLASS+DRUG+RESISTANT+HIV-1+FROM+HEAVILY+TREATMENT+EXPERIENCED+SUBJECTS+-+ScienceDirect&amp;index=1&amp;md5=3e41065814fb28fb7a036272250e962d">LERONLIMAB (PRO 140) ACTIVITY AGAINST 4-CLASS DRUG RESISTANT HIV-1 FROM HEAVILY TREATMENT EXPERIENCED SUBJECTS - ScienceDirect</a>
This project was a collaborative effort among scientists and researchers from:
<ol>
<li>University of Milan, Milan, Italy</li>
<li>University of Siena, Siena, Italy</li>
<li>University of Rome Tor Vergata, Rome, Italy</li>
<li>San Raffaele Vita-Salute University, Milan, Italy</li>
<li>Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy</li>
<li>Azienda Ospedaliera San Paolo, Milan, Italy</li>
<li>University of Perugia, Perugia, Italy; 8 Santa Maria Annunziata Hospital, Florence, Italy; 9 University of Brescia, Brescia, Italy.</li>
</ol>
The study was conducted as an&nbsp;in-vitro&nbsp;study of 25 HIV-1-infected patients harboring a documented 4-class drug-resistance nucleoside reverse transcriptase inhibitors (&quot;NRTIs&quot;), non-nucleoside reverse transcriptase inhibitors (&quot;NNRTIs&quot;), protease inhibitors (&quot;PIs&quot;), and integrase strand transfer inhibitors (&quot;INSTIs&quot;) enrolled in the Italian PRESTIGIO Registry.
Significant findings from the study and observations from the authors include:
<ol>
<li>Leronlimab maintained full activity in the presence of extensive resistance to the four main antiviral classes.</li>
<li>Leronlimab IC50 did not appear significantly altered by previous or current exposure to maraviroc.</li>
<li>In vitro,&nbsp;leronlimab and maraviroc have been reported to have synergistic activity, further corroborating the different mechanism of the two drugs despite the same CCR5 target.</li>
<li>In vitro&nbsp;susceptibility to leronlimab is not affected by extensive drug resistance and exposure to maraviroc.</li>
<li>Leronlimab may have some advantages over maraviroc as a clinically valuable CCR5 antagonist, including lower toxicity, less drug-drug interaction issue and less frequent dosing.</li>
<li>Leronlimab can play a key role in subjects with very limited therapeutic options and CCR5-tropic virus.</li>
</ol>
&quot;We would like to thank our Italian colleagues for understanding the importance of leronlimab in the treatment of HIV. This is further proof that leronlimab can benefit CCR5 tropic HIV patients, including those patients with multidrug resistance. HIV patients deserve the opportunity for multiple, effective treatment options,&quot; said CytoDyn&#39;s Chief Medical Officer, Scott A. Kelly M.D.
Nader Pourhassan, Ph.D., CytoDyn&#39;s President and Chief Executive Officer, commented, &quot;I would like to thank Dr. Stefano Rusconi, who had reached out to us to do this study. We are grateful to him and his colleagues for producing what we believe to be further evidence that leronlimab can play a vital role in the treatment of HIV. We believe leronlimab has many advantages, including protecting healthy cells from viral entry, prevention of HIV transmission, convenience, lower toxicity, and the ability to treat patients across the full spectrum of disease from treatment-naive to 4-class resistant HIV. Many HIV patients could also be in danger of developing NASH and, with our recent 350 mg open label NASH trial having achieved its primary (PDFF) and secondary (cT1) endpoints, we believe that all HIV patients may benefit from a CCR5 product as part of their medication. We also believe leronlimab&#39;s potential role in cancer treatment could help HIV patients with a long history of HIV (especially heavily treatment experienced HIV), which increases their risk of developing cancer.&quot;

CytoDyn Highlights Research Paper 'Leronlimab (PRO 140) activity against 4-class drug resistant HIV-1 from Heavily Treatment Experienced Subjects' In ScienceDirect

Pfizer (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/pfe#NYSE">PFE</a>) is arguably one of the biggest leaders in COVID-19 technology, whether it&rsquo;s their vaccine or their newly <a href="https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-oral-antiviral-treatment-covid-19">approved</a> oral antiviral called Paxlovid. The groupthink is that if anyone is going to end the pandemic, PFE would be the best name to bet on. Moderna (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/mrna#NASDAQ">MRNA</a>) is another name, but the lack of any COVID therapeutic handicaps it. Gilead (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/gild#NASDAQ">GILD</a>) pulled in great numbers initially because doctors had to use it at the time, but its viral inhibitor failed to control the pandemic. Merck&rsquo;s (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/mrk#NYSE">MRK</a>) newly <a href="https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-additional-oral-antiviral-treatment-covid-19-certain">approved</a> Molnupiravir is shrouded in controversy and full of restrictions. Rounding out the contenders is CytoDyn (OTCMKTS: CYDY) with its positive phase 3 trial design for critical patients that just got the FDA&rsquo;s attention and might have a chance to take death off the table. Sitting in between all these names is Todos Medical (OTCMKTS: TOMDF) with the next major oral antiviral to readout expected in the coming weeks along with a diagnostic test that with early detection in the 1-3 day range could dramatically curb the contagion with accurate early detection.
Path 1: A Vaccine a Day to Keep the Pandemic Away
The political arena initially vowed to help develop therapies as well as vaccines for COVID-19, but the lion&#39;s share of the Operation Warp Speed (OWS) money went to vaccine makers. Dozens of small to medium biotech companies were vying for therapeutic solutions, but they had to go it alone. Ironically, the smallest and most poorly capitalized biotechs seemed to have developed the most novel solutions. Many haven&rsquo;t seen the light of day, but a few have survived and made it into this article.
The COVID-19 pandemic should have unified mankind against the virus, instead, it became a political debate topic for the USA 2020 presidential elections. Just last year President Biden vowed to <a href="https://www.theguardian.com/us-news/video/2020/oct/23/joe-biden-coronavirus-shut-down-video">shut down the virus</a>. Everyone is now walking back on those statements with Fauci suggesting <a href="https://www.dailywire.com/news/its-not-an-either-or-fauci-suggests-masks-are-forever-vaccinated-or-unvaccinated">masks could be forever</a>, Kamala claiming that they were &ldquo;not victorious&rdquo; and &ldquo;<a href="https://www.businessinsider.com/vice-president-kamala-harris-said-we-didnt-see-omicron-coming-2021-12">didn&rsquo;t see Omicron coming</a>&rdquo; while <a href="https://www.dailywire.com/news/harris-admits-admin-has-not-been-victorious-in-fighting-pandemic-we-didnt-see-variants-coming">placing the blame</a> on scientific advisors. Politicians were warned that coronaviruses are highly mutagenic and can create new, <a href="https://journals.asm.org/doi/10.1128/JVI.01394-09">dangerous variants</a> seemingly out of nowhere and that a vaccination-only strategy might work in the short run but was doomed to failure in the long run.
Just a few months ago political pundits were blaming the continued viral outbreaks as a &ldquo;<a href="https://www.usnews.com/news/health-news/articles/2021-09-01/a-sound-bite-reexamined-pandemic-of-the-unvaccinated">pandemic of the unvaccinated</a>&rdquo; in an effort to double down on the vaccination blitzkrieg strategy, despite the well-known facts that vaccinations only reduce transmission slightly, with one study suggestion reduction by about <a href="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00648-4/fulltext">one third</a>. This phrase even got <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02243-1/fulltext">blowback from The Lancet </a>about stigmatization. In August unvaccinated people were <a href="https://www.cnbc.com/2021/08/24/cdc-study-shows-unvaccinated-people-are-29-times-more-likely-to-be-hospitalized-with-covid.html">29 times more likely </a>to be hospitalized with COVID-19 and now the CDC stopped tracking that statistic. Washington state shows unvaccinated are <a href="https://www.doh.wa.gov/Portals/1/Documents/1600/coronavirus/data-tables/421-010-CasesInNotFullyVaccinated.pdf">12 times more likely</a> to be hospitalized but the trend lines are converging as a greater portion of the population experiences breakthrough infections. Now infections are reportedly through the roof with Omicron being highly transmissible and <a href="https://www.nature.com/articles/d41586-021-03672-3">evading the immune system</a>. The strategy to encourage more vaccinations is to push by potentially <a href="https://www.washingtonpost.com/health/2021/12/19/fully-vaccinated-booster-omicron-coronavirus-definition/">changing the definition of fully vaccinated</a> to include a booster.
Some vaccine skeptics seem to have grasped that the coronavirus mutates, and immunity eventually wanes. Those facts suggest that vaccines can&rsquo;t snuff out the virus by itself. Now treatments are in the spotlight. With the White House and health officials scrambling to find a solution in light of <a href="https://www.washingtonpost.com/nation/2021/11/05/covid-delta-variant-live-updates/">lawsuits filed over the vaccine mandates</a>, they finally have no place to turn but to treatments. And by the way, this multifaceted strategy is what society has used against the flu for a long time&mdash;vaccines for those who want them, and antivirals like Roche&rsquo;s (OTCMKTS: RHHBY) Tamiflu for those who get sick.
Path 2- Therapeutics and Antivirals
The best COVID treatments are administered early before patients really get bad and have to be intubated on a ventilator in the hospital. This basically leaves two main options: monoclonal antibodies such as those produced by Regeneron (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/regn#NASDAQ">REGN</a>) and Eli Lilly (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/lly#NYSE">LLY</a>), and antivirals like Molnupiravir and Paxlovid from the likes of Merck and Pfizer. The monoclonal antibodies <a href="https://www.fredhutch.org/en/news/releases/2021/10/monoclonal-antibody-treatment-highly-effective-at-reducing-COVID-19-hospitalizations.html">were highly effective</a> but now there&rsquo;s a big concern that they don&rsquo;t work well on Omicron. It was initially unclear why they wouldn&rsquo;t simply test people for the variant first, but recent CDC guidance to the testing labs prohibits them from disseminating the variant of concern to either the patient or the doctor. Without the ability to determine the Omicron variant, hospitals like Mt. Sinai were forced to <a href="https://endpts.com/us-ships-out-all-remaining-supplies-of-the-only-covid-treatment-that-works-against-omicron/">suspend use</a> of Regeneron and Lilly&rsquo;s antibody infusions which no longer work on Omicron. The new case prevalence of Omicron <a href="https://covid.cdc.gov/covid-data-tracker/#variant-proportions">is 73.2%</a> but the lack of variant testing means people also don&rsquo;t know if they have any potential vaccine immunity based on the variant.
The only approved antibody cocktail that is left is sotrovimab, a drug produced by Vir Biotechnology (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/vir#NASDAQ">VIR</a>) and GlaxoSmithKline (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/gsk#NYSE">GSK</a>). But the supply is <a href="https://www.washingtonpost.com/health/2021/12/16/monoclonal-antibody-sotrovimab/">limited</a> (350,000 doses by January) and either they&rsquo;ll have to be used up or testing for the specific variant will have to be done before administering the other monoclonal antibodies.
Antivirals, on the other hand, may represent a much more durable way to treat the virus. However, there are limited options that have been proven to work, with Pfizer&rsquo;s Paxlovid clearly in the lead with regards to efficacy. Furthermore, monoclonal antibodies are more expensive to manufacture, store, and transport compared to small molecule drugs of those made from natural sources. Monoclonals also require intravenous infusion. Either early-stage therapeutics or antiviral treatments are needed.
Hybrid Approach - Testing / Antiviral / Vaccine Booster
Vaccines and boosters have limited utility in controlling the contagion without knowing the neutralizing antibody levels of people to determine who really has adequate protection. Only increased testing will plug this hole in the pandemic plan. Testing could also provide a more accurate picture of the true level of herd immunity because it would then include the vaccinated and the natural immunity from infections. There is also considerable community spread that has gone unchecked due to lack of testing and reliance on vaccination status. Without the government paying for free tests people choose to be tested when they are symptomatic instead of on a regular basis. Increased testing frequency could reduce community spread thereby reducing the contagion.
Breakthrough infections spread disease just as much as a new infection. People are contagious on average 10 days because there are no antivirals to give the masses to get them better quicker. Antivirals hold the promise of lowering the time a person is infectious. A key point in ending the pandemic.
Ultimate COVID-19 Possibility Stock?
Whether the reduction in contagion comes from increasing testing to control community spread, or better management of boosters, or employing antivirals to reduce the time of infectivity, all roads may lead to a company like Todos Medical.
Their testing business and nutraceutical sales are reported to be booming. Their companion diagnostic (3CL protease test called Tollotest) for early 1-3 day detection could replace PCR as a standard test. Trial results for Tollovir are coming soon. They hosted a <a href="https://www.youtube.com/watch?v=22NolgfaoPA">Key Opinion Leader webinar</a> session for Tollovir as a treatment for COVID-19. One of the KOLs, Dr. Greenberg, is a member of the COVID vaccines advisory team for the Ministry of Health in Israel. He pointed out in the video the quick approval pathway of botanical drugs. This particular piece of information has Todos investors speculating that Tollovir could be approved under an EUA in Israel to keep people safe and the economy going regardless of whether vaccines continue to work or not.
With <a href="https://www.jewishvirtuallibrary.org/latest-population-statistics-for-israel">9.4 million </a>people in Israel and current active cases sitting at over <a href="https://www.worldometers.info/coronavirus/country/israel/#graph-cases-daily">7,000 per day</a>, this may represent a very large market for Todos. The wild card is if Todos can give their drug as a prophylactic or to mild-to-moderate patients, it means a total available market (TAM) in Israel of about 7,000 patients per day before Omicron may ramp up considerably. Mild COVID-19 might not seem like a big deal but it can still result in long-COVID which is a significant, long-term negative for many people, with <a href="https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-long-term-effects/art-20490351">symptoms ranging</a> from GI discomfort, to fatigue, dizziness, nausea, headache, tingling and numbness, and depression.
Even the mass booster strategy might lead to Todos. With mounting evidence suggesting boosters aren&rsquo;t working as well as hoped, how do people know that an additional booster will actually help when the first didn&rsquo;t? The answer is the cPass test, an FDA EUA approved test for determining if a person has immunity by measuring neutralizing antibodies. If the cPass test shows weak or no neutralizing capacity, a person might want to look at whether a booster will work for them.
Taking a Bite Out of the Pandemic
Tollovir and Tollovid have the same mechanisms of action as Pfizer&rsquo;s Paxlovid, which is highly efficacious and is expected to generate $24 billion and $33 billion in <a href="https://www.nytimes.com/2021/12/14/health/pfizer-covid-19-pill-paxlovid.html">revenue</a> in 2022 and 2023, respectively. Todos Medical&rsquo;s CEO seems extremely confident regarding all aspects of the business, especially Tollovir.
<img alt="" src="https://www.benzinga.com/files/u447498/screen_shot_2021-12-29_at_2.29.02_pm.png" style="height:348px; width:600px" />
Todos only has a market capitalization of less than $70 million, but some are saying that Tollovir, its COVID-19 antiviral, has the same potential as Pfizer&rsquo;s Paxlovid. In the meantime, revenues are reportedly ramping up from nutraceutical sales and testing, and the company has an impressive pipeline past COVID. For an OTC microcap biotech stock, this might be a good one to watch.
The preceding post was written and/or published as a collaboration between Benzinga&rsquo;s in-house sponsored content team and a financial partner of Benzinga. Although the piece is not and should not be construed as editorial content, the sponsored content team works to ensure that any and all information contained within is true and accurate to the best of their knowledge and research. The content was purely for informational purposes only and not intended to be investing advice.

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Two Paths to End the Pandemic but the Hybrid Approach Looks Dominant

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The following post was written and/or published as a collaboration between Benzinga&rsquo;s in-house sponsored content team and a financial partner of Benzinga.
As the 3rd quarter came to a close in September, the OTC Markets saw a slight decrease in total trading volume even as companies reported quarterly earnings. As has been the theme in 2021 cryptocurrency trusts from Grayscale Investments LLC drove the most volume along with some standouts from the biotech and energy sectors experiencing impressive volume as well.
In September, the combined total dollar volume on OTC Markets reached just over $51.1 billion, edging 2.7% lower than the previous month&rsquo;s volume. The OTCQX and OTCQB markets, however, remained relatively unchanged compared to August dollar volume numbers.
<h2>OTCQX</h2>
Grayscale Ethereum Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/ethe#OTCQX">ETHE</a>) and Grayscale Bitcoin Trust (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/gbtc#OTCQX">GBTC</a>)&nbsp; traded places as the top 2 securities on the OTCQX Best Market in terms of dollar volume for the month with ETHE taking the top spot. Institutional traders may have driven this shift as a new <a href="https://data.cryptocompare.com/reports/digital-asset-management-review-september-2021">report</a> found that institutions preferred ETHE over GBTC <a href="https://www.benzinga.com/markets/cryptocurrency/21/10/23209459/for-the-first-time-ever-institutional-traders-favor-grayscales-ethereum-trust-over-bitcoin">for the first time ever</a> in September.
The OTCQX also witnessed some international standouts. Tesco PLC (OTCQX: TSCDY,) a United Kingdom-based grocery store and general merchandise retailer, experienced a 146% increase in September trading volume. The company is expected to report strong results in October and has also seen consistent sales growth throughout the pandemic.
Netherlands-based paint company Akzo Nobel N.V. (OTCQX: <a class="ticker" href="https://www.benzinga.com/stock/akzoy#OTCQX">AKZOY</a>) saw a precipitous fall in the price of its shares in both August and September, which may be one of the factors that drove a 114% increase in its trading volume in September. The company also reported a disappointing quarter in August.
<h2>OTCQB</h2>
In the OTCQB Venture Market, Netlist Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/nlst#OTCQB">NLST</a>) maintained its No. 1 spot as far as trading volume for the month of September, followed closely by CytoDyn Inc. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/cydy#OTCQB">CYDY</a>) which jumped to the No. 2 spot.
CytoDyn has made headlines recently with its cancer and HIV therapeutic leronlimab that it is currently testing for possible COVID-19 applications. Nevertheless, the company has also been experiencing some internal strife between activist investors and leadership.
The largest changes in month-over-month dollar volume in the OTCQX market came from a handful of energy companies.
Australian energy companies Boss Energy Ltd. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/bqssf#OTCQB">BQSSF</a>), which recently joined the OTCQB Venture Market, and Bannerman Energy LTD. (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/bnnlf#OTCQB">BNNLF</a>) both saw substantial increases in trading volume in September.
Both companies announced positive advancements in their respective Uranium mining projects. Bannerman announced that it would begin a new uranium mining project in Namibia, and Boss also reported it is ahead of schedule in its Australian mining operations.
enCore Energy Corp.&nbsp; (OTCQB: <a class="ticker" href="https://www.benzinga.com/stock/encuf#OTCQB">ENCUF</a>) also had an increase in trading volume for the month of September on news that it had successfully completed its acquisition of Azarga Uranium creating a leading uranium mining company with a plethora of U.S.-based projects.
Below are the top 10 most actively traded securities on the OTCQX and OTCQB markets in September:
<h2>OTCQX</h2>
<img alt="screenshot_2021-10-12_at_5.28.58_pm.png" src="https://www.benzinga.com/files/images/2021/October/12/screenshot_2021-10-12_at_5.28.58_pm.png" style="height:402px; width:1139px" />
<h2>OTCQB</h2>
<img alt="screenshot_2021-10-12_at_5.29.17_pm.png" src="https://www.benzinga.com/files/images/2021/October/12/screenshot_2021-10-12_at_5.29.17_pm.png" style="height:399px; width:1142px" />
The preceding post was written and/or published as a collaboration between Benzinga&rsquo;s in-house sponsored content team and a financial partner of Benzinga. Although the piece is not and should not be construed as editorial content, the sponsored content team works to ensure that any and all information contained within is true and accurate to the best of their knowledge and research. This content is for informational purposes only and not intended to be investing advice.

Movers & Shakers

BNNLF

BQSSF

ENCUF

These OTC Markets Securities had the Most Trading Activity in September

Offerings

ADVM

AGTC

AKYA

AMGN

AMTI

ANGN

APDN

APTX

ARAV

ASRT

ATXI

AYTU

AZYO

BCYC

BDTX

BIVI

BPTS

BSGM

BVXV

CALT

CASI

CCXI

CLBS

CLLS

Chemomab Therapeutics Ltd. - American Depositary Shares

CMMB

CPRX

CVAC

DICE

DNLI

DRRX

EIGR

ENSC

ENTA

ESPR

FBRX

FDMT

FMTX

GANX

GKOS

GLPG

GLTO

GMDA

GRPH

HARP

HCWB

HOOK

HOTH

HRTX

HSTO

IMRA

IMRN

IMUX

INCY

INDP

KALA

KLDO

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