Ultime notizie per Leap Therapeutics (NASDAQ:LPTX) Azioni

Leap Therapeutics

Leap Therapeutics Inc is a biopharmaceutical company developing novel biomarker-targeted antibody therapies designed to treat patients with cancer by inhibiting fundamental tumor-promoting pathways, targeting cancer-specific cell surface molecules, and harnessing the immune system to attack cancer cells. The company's key clinical-stage drug candidate is sirexatamab (DKN-01), which targets Dickkopf-related protein 1 (DKK1) and is being studied in a clinical trial in patients with colorectal cancer. In addition, it also has a preclinical program to develop a proprietary monoclonal antibody, called FL-501 which works by inhibiting the GDF-15 protein.

Leap Therapeutics Inc

Greg Abel, Warren Buffett's successor at Berkshire Hathaway (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BRK#NYSE">BRK</a>) (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BRK#NYSE">BRK</a>), is no longer waiting in the wings—he's already stepping into the role of chief executive in practice.
What Happened: On Friday, in an interview with CNBC, Sue Decker, lead director of Berkshire Hathaway's board, said Abel has begun actively taking on core leadership responsibilities, particularly in capital allocation.
"In the last year, the board, really Greg and Warren, have moved from sort of preparing for success to actually practicing it," Decker said. "Greg has gotten much more involved in capital allocation decisions, and I know he's earned the trust of the board and Warren in that."
Also Read:&nbsp;<a href="https://www.benzinga.com/25/02/43900955/berkshire-hathaways-q4-profits-soar-71-warren-buffett-says-his-firm-has-paid-more-taxes-than-tech-titans-in-trillions" target="_blank" rel="noreferrer noopener">Berkshire Hathaway Q4 Profits Soar 71%, Buffett Says Firm Pays More Taxes Than ‘Tech Titans' With Market Value in ‘Trillions'</a>
Decker added that Abel is no longer viewed internally as a "CEO-in-waiting" because he is already taking on the leadership role.
When questioned about <a href="https://www.benzinga.com/news/earnings/25/02/43903272/buffetts-assures-berkshire-hathaway-shareholders-amid-skyrocketing-cash-reserves">Berkshire's sizable cash reserves</a>, Decker explained that the company views its cash not as unused funds but as a deliberate strategic asset.
"When you think about what's going on right now in the world, there's really no other company in the world that has a fortress of a balance sheet that also could be used to help stabilize or provide liquidity if some major financial market dislocation happened," she stated.
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Why It's Important: "At 94, it won&#8217;t be long before Greg Abel replaces me as CEO and will be writing the annual letters," Buffett wrote in the <a href="https://www.benzinga.com/news/earnings/25/02/43903538/buffetts-key-lessons-in-berkshire-annual-letter-really-outstanding-businesses-are-very-seldom-offered-in-their-entirety">annual shareholder letter</a> released in February earlier this year.
Throughout the letter, the Oracle of Omaha hinted it multiple times that Abel is an active participant in the senior decision-making process.
On the first Saturday of May, Berkshire is expected to hold its annual shareholders meeting. It is highly speculated that Buffett may address tariffs for the first time since Donald Trump's "Liberation Day" announcement, <a href="https://fortune.com/article/warren-buffett-berkshire-hathaway-annual-shareholder-meeting-greg-abel-succession/">reported</a> Fortune.
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Disclaimer:&nbsp;This content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.
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Warren Buffett's Right-Hand Man Greg Abel Is Quietly Taking Over Day-To-Day Leadership At Berkshire Hathaway: 'Gotten Much More Involved In Capital Allocation Decisions'

Nvidia Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) is reportedly developing redesigned artificial intelligence chips for major Chinese tech firms after warning that tightened U.S. export restrictions on its H20 chip could <a href="https://www.benzinga.com/25/04/44830406/nvidia-to-take-55-billion-hit-over-china-chip-export-restrictions-but-top-analyst-dan-ives-says-hes-not-overly-concerned-all-part-of-the-high-game-of-poker">lead to multibillion-dollar losses</a>.
What Happened: Nvidia has informed key Chinese customers — including Alibaba Group (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BABA#NYSE">BABA</a>), ByteDance and Tencent Holdings (OTC:<a class="ticker" href="https://www.benzinga.com/stock/TCEHY#OTC">TCEHY</a>) — that it is working on new AI chip designs tailored to comply with U.S. export regulations, reported Reuters, <a href="https://www.theinformation.com/articles/nvidia-working-china-tailored-chips-u-s-export-ban">citing</a> The Information on Friday.
Nvidia CEO Jensen Huang discussed the new plans with customers during a mid-April trip to Beijing, the report noted, citing three people involved in the conversation. This was shortly after the company disclosed that the export restrictions could result in a $5.5 billion revenue hit.
A prototype of the redesigned chip could be ready as early as June, the report said. Additionally, Nvidia is said to be developing a China-specific version of its Blackwell AI chip.
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Why It's Important: Earlier this week, Brian Colello, equity strategist at Morningstar, voiced a <a href="https://www.benzinga.com/25/04/45092827/nvidia-to-face-significant-market-loss-in-china-amid-huaweis-ai-chip-development-says-analyst-its-pretty-much-game-over-for-nvidia-in-china">pessimistic view of Nvidia's</a> business outlook in China but remained optimistic about the company's performance in developed markets.
Colello pointed to rising competition from Huawei as a major challenge, saying, "I think it's pretty much game over for Nvidia in China."
On Thursday, Nvidia CEO Jensen Huang told U.S. lawmakers that <a href="https://www.benzinga.com/25/05/45157365/nvidia-ceo-jensen-huang-warns-us-lawmakers-that-export-bans-are-backfiring-fueling-huaweis-rise-in-global-ai-chip-race">restrictions on exporting AI chips</a> could be giving China's Huawei Technologies an edge in the global race for AI dominance.
On the same day, Nvidia also took aim at AI startup Anthropic for <a href="https://www.benzinga.com/25/05/45160136/nvidia-blasts-anthropic-for-backing-stricter-chip-bans-on-china-focus-on-innovation-than-tell-tall-tales">advocating stricter U.S. export controls</a> on AI chips to China.
Price Action: On Friday, Nvidia shares climbed 2.59%, ending the day at $114.50, according to <a href="https://pro.benzinga.com/dashboard">Benzinga Pro</a>.
Benzinga Edge Stock Rankings awarded Nvidia an impressive growth score of 94.84%. <a href="https://www.benzinga.com/premium/ideas/benzinga-edge-2#:~:text=Turn%20Market%20Chaos,when%20markets%20rebound">Click here to compare it with other leading tech firms</a> like Alibaba and Tencent.
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Disclaimer:&nbsp;This content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.
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Nvidia Reportedly Designing New AI Chips For Alibaba, ByteDance, Tencent After Jensen Huang-Led Company Warned US Export Ban On H20 Could Cost $5.5 Billion

<ul>
<li>President Donald Trump signed an executive order halting funding for NPR and PBS on Thursday</li>
<li>The order cited the outlets' "biased" and "partisan" news coverage as the reason for the decision</li>
<li>NPR and PBS have both issued statements saying they intend to challenge the order</li>
</ul>
Federal funding for National Public Radio and the Public Broadcast Service was halted on Thursday, after President Donald Trump signed an <a href="https://www.whitehouse.gov/presidential-actions/2025/05/ending-taxpayer-subsidization-of-biased-media/">executive order</a> directing the Corporation for Public Broadcasting to halt the outlets' funding.
The order said the decision was made because both NPR and PBS publish news that is "biased" and "partisan."
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"Unlike in 1967, when the CPB was established, today the media landscape is filled with abundant, diverse, and innovative news options," the order read. "Americans have the right to expect that if their tax dollars fund public broadcasting at all, they fund only fair, accurate, unbiased, and nonpartisan news coverage… neither entity presents a fair, accurate, or unbiased portrayal of current events to taxpaying citizens."
A separate <a href="https://www.whitehouse.gov/articles/2025/05/president-trump-finally-ends-the-madness-of-npr-pbs/">statement</a> put out by the White House said that NPR and PBS are "entities that receive tens of millions of dollars in taxpayer funds each year to spread radical, woke propaganda disguised as ‘news.'"&nbsp;
The statement cited several examples of stories the Trump administration considered "trash that passed for ‘news'" or intolerant of "non-leftist viewpoints," including a "Sesame Street" segment that addressed racism during the Black Lives Matter movement and several NPR stories that dismissed the theory that COVID-19 originated in a lab.
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Previously, the public broadcasters have received half a billion dollars each year in public funding through CPB, according to <a href="https://www.cnbc.com/2025/05/02/trump-signs-executive-order-to-stop-federal-funding-for-npr-and-pbs.html">CNBC</a>.&nbsp;
Both PBS and NPR responded to the executive order on Friday.
PBS President and CEO Paula Kerger issued a <a href="https://www.pbs.org/about/about-pbs/blogs/news/pbs-statement-on-executive-order-regarding-public-media/#:~:text=%E2%80%9CThe%20President's%20blatantly%20unlawful%20Executive%20Order%2C%20issued,serve%20our%20member%20stations%20and%20all%20Americans.%E2%80%9D">statement</a> saying, "The President's blatantly unlawful Executive Order, issued in the middle of the night, threatens our ability to serve the American public with educational programming, as we have for the past 50-plus years.&nbsp; We are currently exploring all options to allow PBS to continue to serve our member stations and all Americans."
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In a lengthier <a href="https://www.npr.org/2025/05/02/g-s1-64016/npr-statement-on-white-house-executive-order">post</a>, Katherine Maher, NPR's president and CEO, said, "We will vigorously defend our right to provide essential news, information and life-saving services to the American public. We will challenge this Executive Order using all means available."
Patricia Harrison, the president and CEO of CBP, also made a <a href="https://cpb.org/pressroom/Corporation-Public-Broadcasting-Statement-Regarding-Executive-Order-Public-Media">statement</a> on Friday that shared similar sentiments with NPR and PBS. "CPB is not a federal executive agency subject to the President's authority. Congress directly authorized and funded CPB to be a private nonprofit corporation wholly independent of the federal government," it read. "In creating CPB, Congress expressly forbade ‘any department, agency, officer, or employee of the United States to exercise any direction, supervision, or control over educational television or radio broadcasting, or over [CPB] or any of its grantees or contractors."
The executive order can be challenged in court.
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Personal Finance

Trump Calls NPR And PBS 'Biased And Partisan,' Signs Executive Order To Stop Funding

<a href="https://www.benzinga.com/news/25/03/44209579/unprecedented-slide-tesla-sales-plummet-45-in-europe-as-musks-net-worth-dives-5-2b-in-a-week">Elon Musk's</a> artificial intelligence startup, xAI is under scrutiny in Memphis, Tennessee.The company is accused of operating dozens of unpermitted gas turbines at a major data center. The situation has raised concerns over public health and potential violations of federal and local environmental laws.
The allegations were outlined in an <a href="https://southernenvironment.sharefile.com/share/view/b1dd4073b14940e2/foa5f606-cfa3-493f-9496-ec0eb02ddb2a">April 9 letter</a> from the Southern Environmental Law Center to the Shelby County Health Department. Memphis is in Shelby County.&nbsp;
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SELC claims xAI is using a former Electrolux manufacturing site for its AI operations. It says the company installed and is operating 35 natural gas turbines—more than double the 15 turbines listed in its initial permit application.
<h2 class="wp-block-heading">Residents Alarmed by Scale of Unpermitted Emissions</h2>
The SELC said emissions data provided by the turbines' manufacturer show the facility is releasing between 1,200 and 2,100 tons of nitrogen oxides, annually.&nbsp;
These pollutants are known contributors to respiratory illnesses and smog. If confirmed, the site would be the largest industrial emitter of nitrogen oxides in Memphis, the SELC said. "We're profoundly overburdened with industrial pollution," the SELC added, highlighting concerns about the cumulative strain on the health of local residents.
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The turbines, which power xAI's high-capacity computing operation involving 100,000 Nvidia&nbsp; (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) H100 chips, have a combined output of approximately 422 megawatts—comparable to a full-scale <a href="https://www.tva.com/energy/our-power-system/natural-gas/brownsville-combustion-turbine-plant#:~:text=Brownsville%20Combustion%20Turbine%20Plant%20sits,constructed%20in%201999%20by%20Enron.">Tennessee Valley Authority's Brownsville</a> gas power plant.&nbsp;
The group said <a href="https://www.benzinga.com/news/25/04/44725803/musks-xai-aims-for-1-million-gpus-in-memphis-but-can-the-citys-grid-handle-a-27b-ai-power-surge">xAI </a>has not disclosed when it intends to decommission the turbines and transition to permanent power from Memphis Light, Gas and Water.
The Memphis data center, referred to internally as "Colossus," began ramping up in 2024 after Musk founded xAI the previous year.&nbsp;
According to SELC, xAI may have violated the Clean Air Act and Shelby County's pre-construction permitting regulations, which require approval before building large-scale pollution sources.&nbsp;
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Amanda Garcia, an attorney for SELC, said in an email to <a href="https://www.cnbc.com/2025/04/10/elon-musks-xai-accused-polluting-air-in-memphis-selc-says-in-letter.html">CNBC</a> that the county has full authority to enforce these regulations and hold the company accountable.
The Shelby County Board of Commissioners held a <a href="https://www.youtube.com/watch?v=ikIsU34DsUs&amp;ab_channel=ShelbyCountyBoardofCommissioners">public hearing </a>on April 9 where residents raised concerns about the health impact of air pollution from the turbines. Community members, including KeShaun Pearson, director of Memphis Community Against Pollution, claimed longstanding issues with respiratory illnesses in Southwest Memphis.
Easter May Knox, who said she lives near the facility, described chronic breathing issues in her family. "When I open up that window, I smell everything but the right thing—and the right thing is the clean air," she said at the hearing.
Local officials and environmental groups also criticized the absence of Brent Mayo, a senior manager at xAI responsible for infrastructure development, after residents said they had invited him to attend the hearing.&nbsp;
SELC is urging the county's health department to issue an emergency stop order and impose daily penalties of $25,000 per violation until xAI complies with the <a href="https://www.epa.gov/clean-air-act-overview">Clean Air Act</a> and air permitting regulations.&nbsp;
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'We're Profoundly Overburdened With Industrial Pollution,' Environmental Group SELC Says As Elon Musk's xAI Is Accused Of Breaking Clean Air Laws

At 58 years old, a <a href="https://youtu.be/kRWv8SlZpQg?si=PJaQYVjcMoLT05lD">caller to "The Ramsey Show"</a> said he's just plain tired. "I'm getting tired of working," he told Dave Ramsey, admitting he has "really nothing saved" for retirement. Despite pulling in $75,000 a year as a trim carpenter, his savings account has barely moved.
When asked why he hadn't put anything aside, he pointed straight to his past. "I was married to a spender, and at the age of 50, got divorced and walked away with zero dollars," he said.
Eight years later, he's still playing financial catch-up — and carrying debt that made Ramsey raise an eyebrow. The caller has $25,000 left on his mortgage and $20,000 on a motorcycle loan. "You almost owe as much on your motorcycle as you do on your house," Ramsey said. "That's weird."
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It was co-host Jade Warshaw who first said the motorcycle needed to go, but Ramsey didn't hesitate to back it up. "It's gone," he said, adding that the bike could become "somebody else's great bike now."
Ramsey also <a href="https://www.benzinga.com/personal-finance/25/01/43117114/it-wont-be-enough-financial-experts-warn-gen-x-about-key-retirement-pitfalls">addressed the caller's exhaustion head-on</a>. While the caller said he didn't feel stuck anymore after getting out of his marriage and paying down debt, Ramsey pointed out that the real issue might be a lack of progress toward a clear finish line. "Part of what's making you tired is you feel stuck," Ramsey said. "If my work is going toward a goal that I'm excited about, I'm not as tired. That's all I'm saying."
Still, Ramsey didn't see the situation as hopeless. Far from it. He mapped out a plan: if the caller buckled down, sold the motorcycle, slashed expenses, and stacked $2,000 a month into savings, he could build a serious retirement cushion.
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"If you saved $2,000 a month for 10 years, you'd have $240,000 plus growth. It'd be a half-million," Ramsey said. "You'd be 67 years old with a <a href="https://www.benzinga.com/money/smartasset">half-million dollars and a paid-for house</a>."
It turned out the caller wasn't starting from scratch: he already had $23,000 in cash, a paid-off truck, and a house worth more than he owed. Ramsey advised him to cancel a $100-per-month term life insurance policy and throw every extra dollar into retirement savings.
The bottom line, Ramsey said, wasn't about feelings — it was about math. "You can't art your way out of this one, you have to science your way out," he told him.
Work more now, stack cash, and by retirement, the Harley wouldn't be the only thing in the rearview mirror.
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58-Year-Old With No Retirement Says His Ex Left Him Broke And He's Sick of Working — Dave Ramsey Says He Can Build a $500K Nest Egg in 10 Years

Saving for retirement can feel like a game of catch-up — and for a lot of Americans, no matter how responsible they've been, it can seem like the finish line keeps moving. Even living debt-free doesn't guarantee you'll wake up at 65 with a pile of cash.
That was exactly the situation for a <a href="https://youtu.be/-6jHkGtFdmU?si=WH8RYcOrgaDulv8S">66-year-old pastor from Kansas City</a> who called "The Ramsey Show" looking for advice.
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"My wife and I pastor a small church," he explained. "It's not a career choice — it's a calling." After decades of modest pay, sometimes even skipping paychecks, he and his wife now bring in around $75,000 a year, helped along by Social Security. They're debt-free except for their home — but their retirement savings sit at just around $35,000.
The couple owes about $85,000 on a home now worth roughly $600,000. On paper, it sounds solid. But as the pastor pointed out, paper wealth <a href="https://www.benzinga.com/personal-finance/25/04/44969001/65-year-old-with-110k-saved-asks-if-he-can-retire-in-7-years-dave-ramsey-says-you-have-no-money-and-tells-him-to-stop-401k-contributions">doesn't necessarily pay the bills in retirement</a>.
Ramsey gave him a clear, practical plan:
"You've got two goals in five years — get the house paid off and put $100,000 into mutual funds."
He mapped it out: by throwing an extra $1,800 a month toward their mortgage, they could eliminate the remaining debt in about two and a half years. After that, if they redirected that $1,800 a month into mutual funds, they'd stack up around $100,000 over the next five years. Combined with the $35,000 they already have — plus typical investment growth — Ramsey estimated they'd be "approaching $200,000" by the time the pastor turns 71.
"And between that and your paid-off $600,000 house, <a href="https://www.benzinga.com/personal-finance/24/11/42026823/this-is-how-you-get-wealthy-dave-ramsey-details-how-one-move-could-make-you-5-million-by-retirement">you're almost a millionaire</a> at that point," Ramsey said.
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The pastor paused, then admitted, "I never thought about it like that."
Of course, <a href="https://www.benzinga.com/personal-finance/24/11/42223593/70-of-millionaires-dont-think-theyre-rich-even-though-people-are-wealthier-than-ever-they-dont-feel-it">whether or not someone feels like a millionaire</a> depends on whether they're willing to cash in the house. Ramsey didn't hammer that point home directly, but it's worth noting: while a paid-off home is incredible security, you can't exactly peel a shingle off the roof and buy groceries.&nbsp;
Selling the house would turn the wealth on paper into something they could actually use — and that's a move Ramsey often suggests for callers in tight spots. Downsizing has practically become one of his signature punchlines, right up there with <a href="https://www.benzinga.com/personal-finance/25/04/44752907/dave-ramsey-says-if-you-want-to-know-what-driving-a-new-car-really-costs-open-your-car-window-once-a-week-and-toss-out-a-100-bill">telling people to sell the car</a> or start living like no one else.
"At least we know you could always sell the house and move to a $400,000 house," Ramsey said, framing it as a solid fallback plan, not a must-do.
Although the next five years would take discipline and hustle, the couple isn't doomed. By staying aggressive with debt payoff, investing steadily, and staying flexible about their housing situation, they still have a real shot at a secure retirement — with a lot more peace and a lot less "wolf" at the door.
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66-Year-Old Pastor And His Wife Only Have $35,000 Saved For Retirement — Dave Ramsey Says 'You Can Sell The House' And Invest In Mutual Funds

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Kirby (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/KEX#NYSE">KEX</a>) has outperformed the market over the past 5 years by 2.3% on an annualized basis producing an average annual return of 16.94%. Currently, Kirby has a market capitalization of $5.94 billion. 
Buying $1000 In KEX: If an investor had bought $1000 of KEX stock 5 years ago, it would be worth $2,095.47 today based on a price of $104.48 for KEX at the time of writing.
<h3>Kirby's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1746229512_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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$1000 Invested In This Stock 5 Years Ago Would Be Worth This Much Today

Agnico Eagle Mines (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/AEM#NYSE">AEM</a>) has outperformed the market over the past 10 years by 2.98% on an annualized basis producing an average annual return of 13.47%. Currently, Agnico Eagle Mines has a market capitalization of $55.88 billion. 
Buying $100 In AEM: If an investor had bought $100 of AEM stock 10 years ago, it would be worth $362.54 today based on a price of $111.15 for AEM at the time of writing.
<h3>Agnico Eagle Mines's Performance Over Last 10 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1746227716_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

If You Invested $100 In This Stock 10 Years Ago, You Would Have This Much Today

UBS analyst Andrew Spinola maintains Viavi Solutions (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VIAV#NASDAQ">VIAV</a>) with a Neutral and lowers the price target from $11.5 to $11.

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UBS Maintains Neutral on Viavi Solutions, Lowers Price Target to $11

UBS analyst Taylor McGinnis maintains Twilio (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TWLO#NYSE">TWLO</a>) with a Buy and lowers the price target from $175 to $150.

TWLO

UBS Maintains Buy on Twilio, Lowers Price Target to $150

UBS analyst Karl Keirstead maintains Atlassian (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TEAM#NASDAQ">TEAM</a>) with a Neutral and lowers the price target from $230 to $215.

TEAM

UBS Maintains Neutral on Atlassian, Lowers Price Target to $215

UBS analyst A.J. Rice maintains Service Corp Intl (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SCI#NYSE">SCI</a>) with a Buy and lowers the price target from $90 to $88.

UBS Maintains Buy on Service Corp Intl, Lowers Price Target to $88

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Leap Therapeutics Announces Completion of Enrollment in Part B of the DeFianCe Study of DKN-01 for the Treatment of Colorectal Cancer Patients

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Leap Therapeutics Reports Third Quarter 2024 Financial Results

Leap Therapeutics to Participate at Piper Sandler 36th Annual Healthcare Conference

Leap Therapeutics to Participate at the 43rd Annual J.P. Morgan Healthcare Conference

Leap Therapeutics Reports Initial Clinical Data from Part B of the DeFianCe Study and Part C of the DisTinGuish Study

Leap Therapeutics Reports Positive Updated Data from Sirexatamab Colorectal Cancer Study

Leap Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results

Driving the Future of Healthcare HIT, OSRH, THTX, LPTX, CSDX, Innovations in Health Insurance, Virtual Care, Oncology, and Chronic Disease Treatment

Leap Therapeutics to Host Virtual KOL Event to Discuss Sirexatamab (DKN-01) in Second-line Patients with Advanced Microsatellite Stable Colorectal Cancer

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