Ultime notizie per Cirata (OTC:WANSF) Azioni

Cirata PLC is a provider of collaboration software for the software development industry. The company offers Active Data Replication, a patented technology that enables the replication of continuously changing data to the cloud and on-premises data centers. The company serves data and source code management markets. In addition, the company offers cloud migration, cloud replication, data lakes, developer collaboration, and other related services. The company currently operates in geographical markets namely: North America, Europe, and the Rest of the World. The majority of the company's revenue is generated from North America.

WIIM

SQNS

Sequans shares are trading higher after the company announced the launch of a bitcoin treasury program.

BYRN

Byrna Technologies shares are trading lower. The company reported Q2 financial results.

JP Morgan analyst Jeremy Tonet maintains Gibson Energy (TSX:<a class="ticker" href="https://www.benzinga.com/stock/GEI#TSX">GEI</a>) with a Underweight and raises the price target from C$22 to C$24.

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TSX:GEI

JP Morgan Maintains Underweight on Gibson Energy, Raises Price Target to C$24

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Macro Economic Events

Economics

Federal Reserve

Fed's Daly Says Waiting For Inflation To Rise Could Leave Fed Behind On Cutting Rates

JP Morgan analyst Kenneth Worthington maintains Franklin Resources (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BEN#NYSE">BEN</a>) with a Neutral and raises the price target from $18 to $22.

JP Morgan Maintains Neutral on Franklin Resources, Raises Price Target to $22

JP Morgan analyst Jeremy Metz maintains First Quantum Minerals (TSX:<a class="ticker" href="https://www.benzinga.com/stock/FM#TSX">FM</a>) with a Neutral and raises the price target from C$17 to C$18.

TSX:FM

JP Morgan Maintains Neutral on First Quantum Minerals, Raises Price Target to C$18

Pfizer Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) and Astellas Pharma Inc. (OTC:<a class="ticker" href="https://www.benzinga.com/stock/ALPMF#OTC">ALPMF</a>) (OTC:<a class="ticker" href="https://www.benzinga.com/stock/ALPMY#OTC">ALPMY</a>) on Thursday <a href="https://newsroom.astellas.us/2025-07-10-XTANDI-R-Plus-Leuprolide-Significantly-Improves-Survival-Outcomes-in-Men-with-Non-Metastatic-Hormone-Sensitive-Prostate-Cancer-with-High-Risk-Biochemical-Recurrence?_gl=1&#x2A;io3uax&#x2A;_gcl_au&#x2A;MTgxMjM4ODIyNy4xNzUwMDg5NzEzLjE2ODQwOTM5MDUuMTc1MDk3NjkxOC4xNzUwOTc2OTE5&#x2A;_ga&#x2A;MTMzODE1NTQwNC4xNzM0MzgyMDk4&#x2A;_ga_MBTGG7KX5Y&#x2A;czE3NTIxNzIzMjMkbzUxOSRnMSR0MTc1MjE3MjkyMSRqNTQkbDAkaDYzMTEyOTQ4MA..">released</a> topline results from the overall survival (OS) analysis from the Phase 3 EMBARK study evaluating Xtandi (enzalutamide), in combination with leuprolide and as a monotherapy, in men with non-metastatic hormone-sensitive prostate cancer with biochemical recurrence (BCR) <a href="https://www.benzinga.com/general/health-care" target="_blank" rel="noreferrer noopener">at high risk for metastasis</a>.
For patients treated with Xtandi plus leuprolide versus placebo plus leuprolide, EMBARK met the key secondary endpoint with a statistically significant and clinically <a target="_blank" href="https://www.benzinga.com/pressreleases/25/07/b46338864/xtandi-plus-leuprolide-significantly-improves-survival-outcomes-in-men-with-non-metastatic-hormone" rel="noreferrer noopener">meaningful improvement in OS</a>.
There was a favorable trend in results towards improved OS for patients treated with Xtandi monotherapy versus placebo plus leuprolide; however, the difference did not reach statistical significance.
Also Read: <a href="https://www.benzinga.com/25/02/43737281/pfizers-talzennaxtandi-combo-improves-survival-outcomes-in-metastatic-castration-resistant-prostate-cancer" target="_blank" rel="noreferrer noopener">Pfizer&#8217;s Talzenna/Xtandi Combo Improves Survival Outcomes In Metastatic Castration-Resistant Prostate Cancer</a>
No new safety signals were observed in the analysis, and the safety results were consistent with Xtandi&#8217;s demonstrated safety profile.
In the EMBARK study, patients were randomized to one of three study arms: Xtandi plus leuprolide, placebo plus leuprolide or XTANDI monotherapy.
An initial analysis was previously reported in <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nejm.org%2Fdoi%2F10.1056%2FNEJMoa2303974%3Furl_ver%3DZ39.88-2003%26rfr_id%3Dori%3Arid%3Acrossref.org%26rfr_dat%3Dcr_pub%2520%25200pubmed&amp;esheet=54287549&amp;newsitemid=20250710409204&amp;lan=en-US&amp;anchor=The+New+England+Journal+of+Medicine&amp;index=1&amp;md5=878c841b90a3bbee8da8c9e6a73ed146" target="_blank" rel="noreferrer noopener">The New England Journal of Medicine</a> in 2023, demonstrating that the study met its primary endpoint with a statistically significant and clinically meaningful improvement in MFS for patients treated with Xtandi plus leuprolide versus placebo plus leuprolide.
The most common adverse events (occurring in ≥10% of patients) in the combination group and the leuprolide-alone group were hot flashes and fatigue. The most common adverse events in the monotherapy group were gynecomastia, hot flashes, and fatigue.
Xtandi is approved in over 80 countries, including the U.S., the EU and Japan.
Detailed OS results from EMBARK will be presented at a future medical meeting.
In May, Astellas and Pfizer <a href="https://www.pfizer.com/news/press-release/press-release-detail/astellas-and-pfizers-xtanditm-enzalutamide-shows-long-term" target="_blank" rel="noreferrer noopener">announced</a> longer-term follow-up results from an open-label extension of the Phase 3 ARCHES study, reporting a five-year follow-up of overall survival (OS) benefits and a 30% reduction in the risk of death in men with metastatic hormone-sensitive prostate cancer (mHSPC) treated with Xtandi plus androgen deprivation therapy (ADT) compared to placebo plus ADT.
In March, the U.S. Food and Drug Administration (FDA) on Friday approved Novartis AG's (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVS#NYSE">NVS</a>) Pluvicto for <a target="_blank" href="https://www.benzinga.com/general/biotech/25/03/44544720/fda-oks-novartis-prostate-cancer-treatment-triples-eligible-patient-pool" rel="noreferrer noopener">prostate cancer patients</a>.
The expanded indication, which approximately triples the number of patients eligible to receive Pluvicto, is based on the Phase 3 PSMAfore trial results.
Novartis is investigating Pluvicto in earlier stages of the disease, including metastatic hormone-sensitive prostate cancer and oligometastatic prostate cancer.
PFE, ALPMY Price Actions: Pfizer stock is up 1.13% at $25.85; Astellas is down 0.64% at $9.40 at publication on Thursday.
Read Next:
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ALPMF

ALPMY

Pfizer, Astellas Report Xtandi Survival Win In Prostate Cancer Study

JP Morgan analyst Anupam Rama maintains Cogent Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/COGT#NASDAQ">COGT</a>) with a Overweight and raises the price target from $25 to $29.

COGT

JP Morgan Maintains Overweight on Cogent Biosciences, Raises Price Target to $29

Carlyle Group shares are trading higher after Citigroup upgraded the stock from Neutral to Buy and raised its price target from $44 to $65.

STMicroelectronics shares are trading higher after the company signed a license agreement with Metalenz.

JP Morgan analyst Tami Zakaria maintains Caterpillar (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CAT#NYSE">CAT</a>) with a Overweight and raises the price target from $395 to $475.

JP Morgan Maintains Overweight on Caterpillar, Raises Price Target to $475

Fed's Daly Says To Cut Rates, Needs A Continuation Of Current Data Trends; Labor Market Supply And Demand Is Roughly In Balance; Economic Fundamentals Support A Move Toward Lower Rates At Some Point; Real Labor Market Weakening Could Drive Rate Cut, But Inflation Issues Could Lean Other Way; Fed Should Always Have An Open Mind About Changing Rates

JP Morgan analyst Tami Zakaria maintains AGCO (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/AGCO#NYSE">AGCO</a>) with a Overweight and raises the price target from $117 to $130.

AGCO

JP Morgan Maintains Overweight on AGCO, Raises Price Target to $130

JP Morgan analyst Patrick Jones downgrades Lundin Mining (TSX:<a class="ticker" href="https://www.benzinga.com/stock/LUN#TSX">LUN</a>) from Overweight to Neutral and raises the price target from C$15.3 to C$15.6.

Downgrades

TSX:LUN

JP Morgan Downgrades Lundin Mining to Neutral, Raises Price Target to C$15.6

Valero Energy shares are trading higher after Piper Sandler maintained an Overweight rating and raised its price target to $160.

Fed's Daly Says I See Two Two Cuts As A Likely Outcome For Fed; There's A Large Amount Of Uncertainty Around Policy Outlook

Fed's Daly Says Labor Market Is Cooling And Growth Is Moderating, But Data Is Not Getting Meaningfully Weaker; Doesn't Expect Very Persistent Inflation Impact From Tariffs; It's Possible Tariffs Don't Create A Large Increase In Prices; It's Time To Think About Adjusting The Interest Rate

IGI Therapeutics SA, a wholly owned subsidiary of New York-based Ichnos Glenmark Innovation Inc., and AbbVie Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ABBV#NYSE">ABBV</a>), on Thursday, announced an exclusive licensing agreement for IGI&#8217;s lead investigational asset, ISB 2001, developed using IGI&#8217;s proprietary BEAT protein platform, for <a href="https://www.benzinga.com/general/health-care" target="_blank" rel="noreferrer noopener">oncology and autoimmune diseases</a>.
&#8220;Multispecifics including trispecific antibodies represent a new frontier in immuno-oncology with the potential to deliver deeper, more durable responses by engaging multiple targets simultaneously,&#8221; said Roopal Thakkar, AbbVie executive vice-president of research and development, and chief scientific officer.
AbbVie will receive exclusive rights to develop, manufacture and commercialize ISB 2001 across North America, Europe, <a href="https://www.benzinga.com/pressreleases/25/07/g46339734/ichnos-glenmark-innovation-igi-and-abbvie-announce-exclusive-global-licensing-agreement-for-isb-20" target="_blank" rel="noreferrer noopener">Japan and Greater China</a>.
IGI will receive an upfront payment of $700 million and is eligible to receive up to $1.225 billion in development, regulatory, and commercial milestone payments, along with tiered, double-digit royalties on net sales.
ISB&nbsp;2001 is a first-in-class trispecific T-cell engager that targets BCMA and CD38 on myeloma cells and CD3 on T cells. It is currently in Phase&nbsp;1 for relapsed/refractory multiple myeloma.
Also Read: <a target="_blank" href="https://www.benzinga.com/markets/large-cap/25/06/46001795/abbvies-migraine-drug-achieves-superiority-in-preventing-headaches-compared-to-generic-treatment-in-head-to-head-trial" rel="noreferrer noopener">AbbVie&#8217;s Migraine Drug Outperforms Generic Treatment In Head-To-Head Trial</a>
Recently presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting as a Rapid Oral Presentation, data from 35 patients demonstrated a sustained overall response rate (ORR) of 79% and a high complete/stringent complete response (CR/sCR) rate of 30% at active doses ≥ 50 µg/kg in a heavily pretreated population of relapsed/refractory myeloma patients, with a favorable safety profile.
U.S. Food &amp; Drug Administration granted ISB&nbsp;2001 Orphan Drug Designation in July 2023 and Fast Track Designation for relapsed/refractory myeloma patients in May 2025.&nbsp;
What&#8217;s Going On With Other Companies: According to a July media report, AstraZeneca Plc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AZN#NASDAQ">AZN</a>) was reportedly in talks with Summit Therapeutics Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SMMT#NASDAQ">SMMT</a>) about a partnership <a href="https://www.benzinga.com/news/contracts/25/07/46249640/astrazeneca-in-15b-talks-for-drug-that-could-upend-lung-cancer-treatment" target="_blank" rel="noreferrer noopener">worth up to $15 billion.</a>
The deal would give AstraZeneca the rights to a lung cancer drug called ivonescimab.
In June, BioNTech SE  (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BNTX#NASDAQ">BNTX</a>) and Bristol Myers Squibb &amp; Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BMY#NYSE">BMY</a>) entered into a co-development and <a href="https://www.benzinga.com/news/health-care/25/06/45723383/bristol-myers-inks-11-billion-licensing-pact-with-biontech-for-bispecific-cancer-drug" target="_blank" rel="noreferrer noopener">co-commercialization agreement</a>.
The pact focuses on BioNTech's investigational bispecific antibody BNT327 across numerous <a target="_blank" href="https://www.benzinga.com/general/health-care" rel="noreferrer noopener">solid tumor types</a>.
Bristol Myers Squibb will pay BioNTech $1.5 billion upfront and $2 billion in non-contingent anniversary payments through 2028. In addition, BioNTech will be eligible to receive up to $7.6 billion in additional development, regulatory and commercial milestones.
ABBV Price Action: AbbVie stock is up 2.63% at $195.63 at publication on Thursday.
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/news/health-care/25/07/46344208/ultragenyx-mereo-shares-dive-as-brittle-bone-disease-drug-misses-early-win" target="_blank" rel="noreferrer noopener">Ultragenyx, Mereo Shares Dive As Brittle Bone Disease Drug Misses Early Win</a></li>
</ul>

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ABBV

BNTX

SMMT

Why Is AbbVie Stock Trading Higher On Thursday?

DLTR

Dollar Tree shares are trading higher after the company announced a $2.5 billion share repurchase authorization.

Fed's Daly Says The Economy Is In A Good Place, Growth And Jobs Solid, Inflation Easing; Fed Has Ability To Restore Price Stability Gently Given State Of Economy; Monetary Policy Is Still Restrictive

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Ultime notizie per Cirata (OTC:WANSF) Azioni

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