| Oct 15, 2026 | James N Wilson | — | SELL | 10.000K | $114.81 | $1.1M |
| Oct 2, 2026 | Roberto Wandenkolk Vieira | PRESIDENT, ONCOLOGY | SELL-OPTIONS | — | $68.86 | $787K |
| Oct 1, 2026 | Joseph Douglas Lyon | SEE REMARKS | SELL-OPTIONS | — | $66.48 | $992K |
| Oct 1, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | — | $62.27 | $2.7M |
| Sep 16, 2026 | Roberto Wandenkolk Vieira | PRESIDENT, ONCOLOGY | SELL | 296.000 | $100.82 | $30K |
| Sep 15, 2026 | James N Wilson | — | SELL | 10.000K | $110.69 | $1.1M |
| Sep 14, 2026 | Joseph Douglas Lyon | SEE REMARKS | SELL-OPTIONS | — | $63.24 | $1.0M |
| Sep 1, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | 183.000 | $61.66 | $2.7M |
| Sep 1, 2026 | Roberto Wandenkolk Vieira | PRESIDENT, ONCOLOGY | SELL-OPTIONS | 174.000 | $66.30 | $5.2M |
| Aug 26, 2026 | Kimberly Park | — | SELL-OPTIONS | — | $67.99 | $3.3M |
| Aug 25, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | — | $68.46 | $3.5M |
| Aug 18, 2026 | David L Mahoney | — | SELL | 103.606K | $118.25 | $12.3M |
| Aug 17, 2026 | Gary Charles Robb | CHIEF BUSINESS OFFICER | SELL | 10.125K | $116.26 | $1.2M |
| Aug 14, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | — | $61.38 | $389K |
| Aug 14, 2026 | James N Wilson | — | SELL | 10.000K | $111.43 | $1.1M |
| Aug 10, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | — | $61.39 | $110K |
| Aug 10, 2026 | William Guyer | CHIEF DEVELOPMENT OFFICER | SELL-OPTIONS | — | $67.54 | $1.5M |
| Aug 4, 2026 | William Guyer | CHIEF DEVELOPMENT OFFICER | SELL-OPTIONS | — | $67.39 | $338K |
| Aug 3, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | — | $61.49 | $2.2M |
| Aug 3, 2026 | Joseph Douglas Lyon | SEE REMARKS | SELL | 1.540K | $114.16 | $176K |
| Jul 30, 2026 | Atabak Mokari | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | — | $68.89 | $7.3M |
| Jul 15, 2026 | James N Wilson | — | SELL | 10.000K | $88.30 | $883K |
| Jul 15, 2026 | Atabak Mokari | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | — | $54.63 | $2.6M |
| Jul 7, 2026 | William Guyer | CHIEF DEVELOPMENT OFFICER | SELL-OPTIONS | — | $57.39 | $1.4M |
| Jul 1, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | — | $48.31 | $2.0M |
| Jun 17, 2026 | David L Mahoney | — | SELL | 20.000K | $84.53 | $1.7M |
| Jun 16, 2026 | James N Wilson | — | SELL | 10.000K | $83.20 | $832K |
| Jun 15, 2026 | Atabak Mokari | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | — | $50.20 | $2.5M |
| Jun 2, 2026 | William Guyer | CHIEF DEVELOPMENT OFFICER | SELL-OPTIONS | — | $46.13 | $979K |
| Jun 1, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | 778.000 | $39.99 | $1.5M |
| Jun 1, 2026 | Atabak Mokari | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 873.000 | $45.03 | $2.0M |
| May 29, 2026 | Joseph K Belanoff | CHIEF EXECUTIVE OFFICER | SELL | 12.837K | $69.74 | $895K |
| May 27, 2026 | Joseph Douglas Lyon | SEE REMARKS | SELL | 5.000K | $65.00 | $325K |
| May 27, 2026 | Sean Maduck | SEE REMARKS | SELL-OPTIONS | — | $36.93 | $4.3M |
| May 5, 2026 | William Guyer | CHIEF DEVELOPMENT OFFICER | SELL-OPTIONS | — | $36.74 | $604K |
| May 1, 2026 | Joseph K Belanoff | CHIEF EXECUTIVE OFFICER | SELL | 40.000K | $50.10 | $2.0M |
