| Jul 30, 2026 | Michael R Hayden | DIRECTOR | BUY | 20.000K | $52.94 | $1.1M |
| Jul 7, 2026 | C. Frank Bennett | EVP, CHIEF SCIENTIFIC OFFICER | SELL | 5.536K | $84.95 | $1.7M |
| Jul 7, 2026 | Allene M Diaz | DIRECTOR | SELL-OPTIONS | — | $66.26 | $387K |
| Jul 7, 2026 | Holly B Kordasiewicz | EVP, CHIEF DEVELOPMENT OFFICER | SELL | 362.000 | $84.30 | $31K |
| Jul 1, 2026 | Joseph Klein, III | DIRECTOR | SELL-OPTIONS | — | $59.49 | $450K |
| Jun 26, 2026 | Joseph Baroldi | EVP, CHIEF BUSINESS OFFICER | SELL-OPTIONS | — | $64.67 | $175K |
| Jun 26, 2026 | Patrick R. O'Neil | EVP CLO & GENERAL COUNSEL | SELL | 3.069K | $80.00 | $246K |
| Jun 26, 2026 | Eugene Schneider | EVP, CHF CLINICAL DEVELOP OFCR | SELL-OPTIONS | — | $70.97 | $524K |
| Jun 25, 2026 | Eric Swayze | EVP RESEARCH | SELL | 10.602K | $79.18 | $839K |
| Jun 24, 2026 | Brett P Monia | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $63.21 | $2.8M |
| Jun 15, 2026 | Spencer R Berthelsen | DIRECTOR | SELL-OPTIONS | — | $48.95 | $393K |
| Jun 12, 2026 | Holly Kordasiewicz | EVP, CHIEF DEVELOPMENT OFFICER | SELL-OPTIONS | — | $63.69 | $1.2M |
| Jun 1, 2026 | Spencer R Berthelsen | DIRECTOR | SELL-OPTIONS | — | $50.05 | $410K |
| May 13, 2026 | Brett P Monia | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $55.54 | $208K |
| May 4, 2026 | Joseph Loscalzo | DIRECTOR | SELL-OPTIONS | — | $61.90 | $2.0M |
| May 1, 2026 | Joseph Klein, III | DIRECTOR | SELL-OPTIONS | — | $60.31 | $267K |
| Apr 28, 2026 | Joseph Baroldi | EVP, CHIEF BUSINESS OFFICER | SELL | 1.626K | $71.79 | $117K |
| Apr 15, 2026 | B. Lynne Parshall | DIRECTOR | SELL | 5.000K | $76.27 | $381K |
| Apr 15, 2026 | Kyle Jenne | EVP, CHF GL PDT STR OFCR | SELL-OPTIONS | 7.324K | $75.17 | $368K |
| Apr 15, 2026 | Brian Birchler | EVP, CORP AND DEVELOPMENT OPS | SELL-OPTIONS | 902.000 | $75.04 | $73K |
| Apr 15, 2026 | Joseph Baroldi | EVP, CHIEF BUSINESS OFFICER | SELL-OPTIONS | 5.218K | $74.56 | $419K |
| Apr 2, 2026 | Shannon Devers | EVP, CHIEF HUMAN RESOURCES OFC | SELL | 6.193K | $74.05 | $459K |
| Apr 1, 2026 | Joseph Klein, III | DIRECTOR | SELL-OPTIONS | — | $57.50 | $806K |
| Mar 19, 2026 | Eugene Schneider | EVP, CHF CLINICAL DEVELOP OFCR | SELL | 5.812K | $70.97 | $412K |
| Mar 16, 2026 | Elizabeth L Hougen | EVP, FINANCE & CFO | SELL | 50.221K | $61.90 | $7.3M |
| Mar 10, 2026 | Kyle Jenne | EVP, CHF GL PDT STR OFCR | SELL-OPTIONS | — | $60.26 | $1.2M |
| Mar 9, 2026 | Patrick R. O'Neil | EVP CLO & GENERAL COUNSEL | SELL | 10.148K | $75.25 | $764K |
| Mar 9, 2026 | Brett P Monia | CHIEF EXECUTIVE OFFICER | SELL | 12.319K | $68.12 | $3.1M |
