La vendita allo scoperto per Novo Nordisk dà agli investitori un'idea del grado in cui gli investitori stanno scommettendo sul declino delle azioni di Novo Nordisk. I dati relativi alle vendite allo scoperto vengono aggiornati ogni due settimane.

Novo Nordisk (NYSE:NVO) Azioni, Report sulle vendite allo scoperto

Novo Nordisk

With roughly one third of the global branded diabetes treatment market, Novo Nordisk is the leading provider of diabetes-care products in the world. Based in Denmark, the company manufactures and markets a variety of human and modern insulins, injectable diabetes treatments such as GLP-1 therapy, oral antidiabetic agents, and obesity treatments. Novo also has a biopharmaceutical segment (constituting roughly 10% of revenue) that specializes in protein therapies for hemophilia and other disorders.

Biotech

Large Cap

News

Health Care

Movers

General

Novo Nordisk presenta Amicretina: una pillola che raddoppia la perdita di peso rispetto a Wegovy e potrebbe rivoluzionare il trattamento.

L&#39;Amicretina raddoppia la perdita di peso rispetto a Wegovy

Equities

Markets

Hims & Hers Health, Inc. Class A Common Stock

HIMS

Novo Nordisk annuncia risultati positivi per il farmaco contro l&#39;obesità infantile; richiesta di approvazione a FDA ed EMA.

Novo Nordisk: il farmaco per l&#39;obesità infantile mostra buoni risultati

Market-Moving Exclusives

Exclusives

VANI

L&#39;impianto GLP-1 di Vivani Medical riduce drasticamente l&#39;82% del grasso epatico: risultati preclinici promettenti per l&#39;obesità.

L&#39;impianto di Vivani riduce drasticamente il grasso epatico

Novo Nordisk AS

Novo Resources Corp Warrants (27/08/2023)

Novo Integrated Sciences, Inc. - Common Stock

Novo Integrated Sciences Inc

The demand for GLP-1 agonists, including Novo Nordisk A/S&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) Ozempic and Wegovy (semaglutide), a class of drugs used to manage diabetes and obesity, continues to grow.
Though initially developed for type 2 diabetes, GLP-1s have gained attention for their effectiveness in weight management. The FDA approval expanded use for <a target="_blank" href="https://www.benzinga.com/general/biotech/24/03/37567088/novo-nordisks-game-changer-fda-approves-weight-loss-sensation-wegovy-for-heart-health-potential-i" rel="noreferrer noopener">cardiovascular indication for Wegovy</a> and potential future applications for chronic kidney disease and non-alcoholic steatohepatitis (NASH) further underscores the <a target="_blank" href="https://www.benzinga.com/general/biotech/24/09/41034046/popular-ozempic-may-have-new-use-as-semaglutide-drugs-linked-to-reduced-overdose-risk-in-diabetic" rel="noreferrer noopener">promise of these treatments</a>.
The Forbes report <a target="_blank" href="https://www.forbes.com/sites/joshuacohen/2024/10/02/weight-loss-from-glp-1-drugs-not-as-robust-in-real-world-settings/" rel="noreferrer noopener">adds</a> that real-world evidence shows that weight loss from GLP-1 usage may not align with the outcomes seen in clinical trials.
A study published in the Journal of the American Medical Association (JAMA) revealed that patients, on average, achieved only a 3.7% weight reduction after one year on the drugs—lower than the results reported in controlled trials.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/09/40986953/novo-nordisk-ceo-to-face-senate-scrutiny-over-high-ozempic-and-wegovy-prices-hearing-scheduled-on" rel="noreferrer noopener">Novo Nordisk CEO To Face Senate Scrutiny Over High Ozempic And Wegovy Prices, Hearing Scheduled On Tuesday</a>.
While patients have high expectations for substantial weight loss, the findings suggest that most individuals did not experience the same degree of benefit as seen in clinical settings.
However, those who persisted with GLP-1 therapy saw results comparable to those in clinical trials.
In another study published in 2023, researchers observed a modest average weight loss of 2.2% over 72 weeks among type 2 diabetes patients on GLP-1s.
Additionally, a pre-print analysis this year found that the real-world effectiveness of GLP-1s was less pronounced than in randomized controlled trials.
This difference underscores the challenge of replicating clinical trial success in everyday medical settings, where factors like medication adherence and real-life conditions are involved.
Persistence with GLP-1 medications is a significant issue. Forbes reported that only 15% of patients who started GLP-1 drugs for weight loss remained on them after two years, citing Prime Therapeutics, a pharmacy benefit manager.
Discontinuation rates were high, with just 29% continuing treatment after one year and a mere 15% after two years.
Other studies, including findings from Blue Cross Blue Shield, show that many patients stop GLP-1 therapy early, often within the first month, before achieving meaningful weight loss.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/general/biotech/24/10/41166018/medicare-drug-price-negotiation-program-gets-final-guidance-for-second-cycle-1-5b-savings-expecte" target="_blank" rel="noreferrer noopener">Medicare Drug Price Negotiation Program Gets Final Guidance For Second Cycle, $1.5B Savings Expected</a>.</li>
</ul>
Photo via Shutterstock

Media

Popular Weight Loss Drugs Like Ozempic Show Gap Between Clinical Trial Promises And Real-World Use, Study Reveals

On Wednesday, the U.S. Department of Health and Human Services (HHS), working via the Centers for Medicare &amp; Medicaid Services (CMS), released final guidance for the second cycle of the <a href="https://www.benzinga.com/general/health-care">Medicare Drug Price Negotiation Program</a>.
This initiative <a target="_blank" href="https://www.cms.gov/newsroom/press-releases/hhs-releases-final-guidance-second-cycle-historic-medicare-drug-price-negotiation-program" rel="noreferrer noopener">aims</a> to provide lower drug prices starting in 2026 and 2027.
It also ensures that people with Medicare can access these negotiated prices, expanding on the groundwork laid in the first cycle of negotiations.
The first round of negotiations focused on 10 specific drugs. Medicare recipients should save approximately $1.5 billion in out-of-pocket costs when the new prices take effect in 2026.
By February 2025, CMS will select up to 15 additional drugs for the second round of negotiations. The selected drugs will undergo negotiations in 2025, with new prices becoming effective in 2027.
They include: 
<ul>
<li>Novo Nordisk&#8216;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) diabetes drug, <a href="https://www.benzinga.com/general/biotech/24/08/40534249/novo-nordisks-ozempic-might-be-among-2027-medicare-price-negotiation-targets">Ozempic,</a></li>
<li>Pfizer Inc.&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) cancer drugs Ibrance and Xtandi</li>
<li>GSK Plc&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GSK#NYSE">GSK</a>) asthma treatment Trelegy Ellipta</li>
<li>Teva Pharmaceutical Industries Ltd.&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TEVA#NYSE">TEVA</a>) Huntington&#8217;s disease drug Austedo, and</li>
<li>Abbvie Inc.&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ABBV#NYSE">ABBV</a>) irritable bowel syndrome treatment Linzess.</li>
</ul>
CMS plans to improve patient-focused engagement during the second cycle of negotiations. It will also organize roundtable events and town hall meetings in 2025.
As Medicare Open Enrollment approaches on Oct. 15, beneficiaries can expect more cost-saving measures in the coming years. That includes a $2,000 annual cap on out-of-pocket drug costs starting in January 2025.
These changes build on other provisions of the Inflation Reduction Act, which was signed by President Joe Biden on Aug. 16, 2022. The legislation included a $35 monthly cap on insulin and free recommended vaccines for adults covered under Medicare Part D.
Monday, the U.S. Department of Health and Human Services (HHS) announced that Medicare enrollees will benefit from reduced prices on 54 drugs through Medicare Part B, effective from Oct. 1, 2024, to Dec. 31, 2024. Some Medicare beneficiaries could see daily savings ranging from $1 to as much as $3,854 on drugs included <a href="https://www.benzinga.com/general/biotech/24/10/41127143/us-hhs-reveal-cost-savings-for-54-prescription-drugs-including-novartis-cancer-drug-ozempic-could" target="_blank" rel="noreferrer noopener">in the rebate program</a>.
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</ul>
Image: Shutterstock

Government

ABBV

TEVA

Medicare Drug Price Negotiation Program Gets Final Guidance For Second Cycle, $1.5B Savings Expected

Hims &amp; Hers Health Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HIMS#NYSE">HIMS</a>) shares are trading lower Thursday in possible sympathy with Eli Lilly And Co&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), after the U.S. Food and Drug Administration removed it from the weight-loss and diabetes drugs <a href="https://www.benzinga.com/markets/equities/24/09/40672154/eli-lilly-launches-discounted-mounjaro-and-zepbound-as-fight-against-compounded-imitations-escal">shortage list</a>.
What Happened: The FDA said in a <a href="https://www.fda.gov/drugs/drug-safety-and-availability/fda-clarifies-policies-compounders-national-glp-1-supply-begins-stabilize">statement</a> late Wednesday that Eli Lilly's supply of Mounjaro, which is used to treat diabetes, and weight-loss drug Zepbound can now keep up with current demand. 
Mounjaro had been on the regulator&#8217;s shortage list since late 2022, and Zepbound had been on the list since April.
&#8220;FDA confirmed with the drug's manufacturer that their stated product availability and manufacturing capacity can meet the present and projected national demand. Patients and prescribers may still see intermittent localized supply disruptions as the products move through the supply chain from the manufacturer and distributors to local pharmacies,&#8221; the FDA said.
Hims &amp; Hers Health shares are under pressure on Thursday as the firm sells cheaper versions of the aforementioned drugs, known as compounded drugs. Hims &amp; Hers said in May that it would&nbsp;begin selling compounded versions&nbsp;of GLP-1 injections. Shares surged on the news and have more than doubled since the start of the year.
Don&#8217;t Miss: <a href="https://www.benzinga.com/general/biotech/24/07/39656549/exclusive-glp-1-weight-loss-drugs-could-become-a-trillion-dollar-market-predicts-tema-etfs-ceo">EXCLUSIVE: GLP-1 Weight-Loss Drugs Could Become A Trillion-Dollar Market, Predicts Tema ETFs CEO</a>
The limited supply for weight-loss and diabetes drugs from Lilly and rival Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) sparked a demand boom for compounded drugs, which are made by combining, mixing, or altering drug ingredients, per Reuters.
The report also indicates that regulators allow compounded versions of drugs to enter the market to meet demand when there is a shortage. When there is no shortage, compounded drug makers are reportedly unable to make &#8220;regular or inordinate amounts&#8221; of the drugs.
Lilly reportedly began selling vials of its lowest dose of Zepbound in the U.S. directly to consumers via its website to help push back against the rise of compounded versions of the drug. Novo Nordisk&#8217;s drugs were still listed on the FDA&#8217;s shortage list as of Thursday. 
HIMS Price Action: <a href="http://benzinga.com/quote/hims">Hims &amp; Hers Health shares</a> were down 8.92% at $17.26 at the time of publication, according to <a href="http://pro.benzinga.com">Benzinga Pro</a>.
Photo: Natalia Varlei from Shutterstock.

Hims & Hers Health Stock Is Tumbling Thursday: Here's Why

Deep-pocketed investors have adopted a bullish approach towards Novo Nordisk (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>), and it's something market players shouldn't ignore. Our tracking of public options records at Benzinga unveiled this significant move today. The identity of these investors remains unknown, but such a substantial move in NVO usually suggests something big is about to happen.
We gleaned this information from our observations today when Benzinga's options scanner highlighted 17 extraordinary options activities for Novo Nordisk. This level of activity is out of the ordinary.
The general mood among these heavyweight investors is divided, with 64% leaning bullish and 35% bearish. Among these notable options, 8 are puts, totaling $451,772, and 9 are calls, amounting to $508,244.
<h3>What's The Price Target?</h3>
Analyzing the Volume and Open Interest in these contracts, it seems that the big players have been eyeing a price window from $70.0 to $135.0 for Novo Nordisk during the past quarter. 
<h3>Analyzing Volume &amp; Open Interest</h3>
In terms of liquidity and interest, the mean open interest for Novo Nordisk options trades today is 703.94 with a total volume of 3,639.00.
In the following chart, we are able to follow the development of volume and open interest of call and put options for Novo Nordisk's big money trades within a strike price range of $70.0 to $135.0 over the last 30 days.
<h3>Novo Nordisk 30-Day Option Volume &amp; Interest Snapshot</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1727895790_0.png" alt="Options Call Chart" />
<h3>Noteworthy Options Activity:</h3>

<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Ask</th>
<th>Bid</th>
<th>Price</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>NVO</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>12/20/24</td>
<td>$5.15</td>
<td>$5.0</td>
<td>$5.1</td>
<td>$125.00</td>
<td>$127.5K</td>
<td>3.5K</td>
<td>2.3K</td>
</tr>
<tr>
<td>NVO</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>01/15/27</td>
<td>$18.6</td>
<td>$17.6</td>
<td>$18.0</td>
<td>$115.00</td>
<td>$90.0K</td>
<td>114</td>
<td>50</td>
</tr>
<tr>
<td>NVO</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>12/20/24</td>
<td>$6.95</td>
<td>$6.9</td>
<td>$6.95</td>
<td>$120.00</td>
<td>$86.8K</td>
<td>250</td>
<td>201</td>
</tr>
<tr>
<td>NVO</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>11/15/24</td>
<td>$11.05</td>
<td>$10.9</td>
<td>$10.9</td>
<td>$125.00</td>
<td>$86.1K</td>
<td>1.3K</td>
<td>120</td>
</tr>
<tr>
<td>NVO</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>01/17/25</td>
<td>$21.0</td>
<td>$20.85</td>
<td>$20.85</td>
<td>$100.00</td>
<td>$83.3K</td>
<td>1.2K</td>
<td>40</td>
</tr>
</tbody>
</table>

<h3>About Novo Nordisk</h3>
With roughly one third of the global branded diabetes treatment market, Novo Nordisk is the leading provider of diabetes-care products in the world. Based in Denmark, the company manufactures and markets a variety of human and modern insulins, injectable diabetes treatments such as GLP-1 therapy, oral antidiabetic agents, and obesity treatments. Novo also has a biopharmaceutical segment (constituting roughly 10% of revenue) that specializes in protein therapies for hemophilia and other disorders.
Following our analysis of the options activities associated with Novo Nordisk, we pivot to a closer look at the company's own performance.
<h3>Novo Nordisk's Current Market Status</h3>
<ul>
<li>With a volume of 4,460,331, the price of NVO is down -1.46% at $116.29. </li>
<li>RSI indicators hint that the underlying stock may be oversold.</li>
<li>Next earnings are expected to be released in 35 days.</li>
</ul>
<h3>Professional Analyst Ratings for Novo Nordisk</h3>
In the last month, 3 experts released ratings on this stock with an average target price of $160.0.
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&#x2A; An analyst from Cantor Fitzgerald downgraded its action to Overweight with a price target of $160. 
&#x2A; An analyst from Cantor Fitzgerald downgraded its action to Overweight with a price target of $160. 
&#x2A; An analyst from Cantor Fitzgerald has revised its rating downward to Overweight, adjusting the price target to $160. 
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If you want to stay updated on the latest options trades for Novo Nordisk, <a href="https://benzinga.grsm.io/register174">Benzinga Pro</a> gives you real-time options trades alerts.

Options

This Is What Whales Are Betting On Novo Nordisk

RBC Capital Markets initiated coverage on Tandem Diabetes Care, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TNDM#NASDAQ">TNDM</a>), a global insulin delivery and diabetes technology company that manufactures and sells advanced automated insulin delivery systems.
The analyst highlights several key growth drivers for Tandem, positioning it for sustained growth over the coming years driven by expansion into the U.S. Type 1 market with a 40% pump penetration (Tandem has a one-third share), which is expected to rise to the mid-60s and Type 2 market with 6% penetration.
The company is also seeking deeper penetration within existing accounts through product innovations.
The analyst also added that the rise of GLP-1s class drugs is not a major threat to insulin pump adoption.
GLP-1 drugs such as Novo Nordisk A/S&#8216; (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) semaglutide as Wegovy and Ozempic and Eli Lilly And Co&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) tirzepatide as Zepbound and Mounjaro, have recently made waves.
RBC analyst highlights that insulin is essential for insulin-dependent patients, as GLP-1 medications cannot regenerate beta cells or halt their deterioration. As a result, the need for insulin remains.
The Type 2 diabetes population, which suffers from irreversible beta cell loss, is underserved.
The growing popularity of GLP-1 drugs may lead to earlier diagnoses of Type 2 diabetes and prompt insulin use, potentially expanding the market.
RBC initiated Tandem with an Outperform, with a price target of $65, citing a significant upside potential driven by earning revisions and multiple expansions.
RBC sees an opportunity for Tandem to achieve profitability over time and projects gross margins of 51% in 2024 or flat y/y to reflect the Mobi launch and investments in several ongoing R&amp;D initiatives.
The analyst sees a clear path for the company to reach its goal of approximately 65% margins, with Mobi accounting for about half of that progress. Further gains are anticipated from planned initiatives.
RBC projects breakeven for 2024, with positive adjusted EBITDA margins expected in the second half of the year.
Price Action: TNDM stock is down 0.37% at $40.92&nbsp;at the last check on Wednesday.
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</ul>

Initiation

Trading Ideas

TNDM

Tandem Diabetes Insulin Pump Demand to Surge Despite Popular Demand Of Weight Loss Drugs, Bullish Analyst Says

Eli Lilly and Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) is making a major move with a $4.5 billion investment to create the Lilly Medicine Foundry, a new research <a href="https://www.benzinga.com/quote/LLY/news">and manufacturing facility</a>.
The goal? To bolster its drug pipeline and develop faster, more efficient ways to bring treatments to market. This move builds on the massive success of its GLP-1 drugs, Mounjaro and Zepbound, which are revolutionizing the obesity treatment landscape and are projected to bring in nearly $19 billion in 2024.
<h2 class="wp-block-heading">From Molecules To Medicines, Says CEO Ricks</h2>
These drugs have quickly become some of the most talked-about products in the weight-loss market, alongside competitors like Novo Nordisk AS's (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) Ozempic and Wegovy.
Beyond obesity drugs, Eli Lilly's pipeline includes 11 obesity-related treatments and ambitious plans to develop therapies for Alzheimer's, ALS, and other neurological conditions. CEO David Ricks emphasized the facility's role in scaling innovative molecules into life-saving medicines: "The idea is to take molecules from a bench in a lab to scaled for medicines in a pharmacy, and this research and development site will do that work."
Read Also: <a href="https://www.benzinga.com/general/biotech/24/10/41141028/eli-lilly-invests-4-5b-in-new-medicine-foundry-for-advanced-drug-manufacturing-to-push-us-pharma-">Eli Lilly Invests $4.5B In New Medicine Foundry for Advanced Drug Manufacturing To Push US Pharma Boundaries</a>
<h2 class="wp-block-heading">Eli Lilly Stock Chart Suggests Near-Term Headwinds</h2>
From a stock perspective, Eli Lilly has had a fantastic year, posting gains of 49% year-to-date and over 64% in the last 12 months. 
However, the technical signals suggest some headwinds in the near term.
<figure class="wp-block-image size-full"><a href="https://www.benzinga.com/pro/?utm_source=BZprocontent100224&amp;t=be2bearmibe3na1"><img loading="lazy" decoding="async" width="630" height="459" src="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02091753/Screenshot-2024-10-02-at-6.45.52-PM.png" alt="" class="wp-image-576525" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02091753/Screenshot-2024-10-02-at-6.45.52-PM.png 630w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02091753/Screenshot-2024-10-02-at-6.45.52-PM-300x219.png 300w" sizes="(max-width: 630px) 100vw, 630px" /></a></figure>
<a href="https://www.benzinga.com/pro/?utm_source=BZprocontent100224&amp;t=be2bearmibe3na1">Chart created using Benzinga Pro</a>
Eli Lilly stock is trading below key short-term moving averages, including the eight-, 20-, and 50-day simple moving averages (SMA), which traditionally signal a short-to-medium-term bearish outlook. However, the stock trades well above the 200-day SMA, suggesting the long-term remains bullish.
<figure class="wp-block-image size-full"><a href="https://www.benzinga.com/pro/?utm_source=BZprocontent100224&amp;t=be2bearmibe3na1"><img loading="lazy" decoding="async" width="630" height="459" src="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02091802/Screenshot-2024-10-02-at-6.47.13-PM.png" alt="" class="wp-image-576526" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02091802/Screenshot-2024-10-02-at-6.47.13-PM.png 630w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02091802/Screenshot-2024-10-02-at-6.47.13-PM-300x219.png 300w" sizes="(max-width: 630px) 100vw, 630px" /></a></figure>
<a href="https://www.benzinga.com/pro/?utm_source=BZprocontent100224&amp;t=be2bearmibe3na1">Chart created using Benzinga Pro</a>
The MACD (Moving Average Convergence/Divergence) indicator is negative at 6.28, reinforcing short-term selling pressure. The RSI (Relative Strength Index) lies in neutral territory at 40.89.
Yet, long-term investors might still see potential in the stock. With a 200-day moving average of $794.34, Eli Lilly could remain a solid investment for the future, particularly as its obesity drugs gain further market share.
While some volatility may persist in the short term, the long-term potential remains strong as Lilly continues to invest in its drug development pipeline.
Read Next: 
<ul>
<li><a href="https://www.benzinga.com/general/biotech/24/10/41137681/eli-lilly-nears-first-trillion-pharma-title-but-investors-caution-amid-sky-high-valuation">Eli Lilly Nears First Trillion Dollar Pharma Title, But Investors Caution Amid Sky-High Valuation</a></li>
</ul>
Photo: Shutterstock

Technicals

Eli Lilly Commits $4.5B To New Facility, Banking On Mounjaro, Zepbound's Weight Loss Success Despite Short-Term Stock Challenges

On Wednesday, Eli Lilly And Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) announced a&nbsp;$4.5 billion&nbsp;investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing <a target="_blank" href="https://www.benzinga.com/pressreleases/24/10/n41138388/lilly-announces-new-4-5-billion-site-the-lilly-medicine-foundry-to-drive-innovation-in-drug-produc" rel="noreferrer noopener">and drug development</a>.
As the company inches closer to becoming the first pharma company in the $1 trillion club, it aims to strengthen its standing as one of the top 10 most valuable firms in the U.S. by <a target="_blank" href="https://www.benzinga.com/general/biotech/24/10/41137681/eli-lilly-nears-first-trillion-pharma-title-but-investors-caution-amid-sky-high-valuation" rel="noreferrer noopener">outpacing its competitors</a>.
In a report, Eli Lilly said it plans to reinvest its revenues into R&amp;D, aiming to escape the pharmaceutical industry&#8217;s traditional boom-and-bust cycle.
The company says the new facility will allow Lilly to research new ways of producing medicines while scaling up the manufacturing of medicines for clinical trials.
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The Medicine Foundry will be the first-ever facility of its kind to combine research and manufacturing in a single location. It will be located in&nbsp;Indiana&#8217;s&nbsp;LEAP Research and Innovation District in&nbsp;Lebanon, Indiana, and will expand the company&#8217;s investment there to more than&nbsp;$13 billion.&nbsp;
This new facility will add to Lilly&#8217;s previous manufacturing commitments in&nbsp;Lebanon, which include a $2.1 billion investment announced in May 2022 to expand its network for active ingredients and new modalities, such as genetic medicines.
In&nbsp;April 2023, the company announced an&nbsp;<a target="_blank" href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4268657-1&amp;h=1606463900&amp;u=https%3A%2F%2Flilly.mediaroom.com%2F2023-04-17-Lilly-to-Make-Record-Breaking-Investment-in-Indiana-Manufacturing-Facilities&amp;a=additional+%241.6+billion" rel="noreferrer noopener">additional&nbsp;$1.6 billion</a> investment.
In&nbsp;May 2024, Lilly announced an&nbsp;<a target="_blank" href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4268657-1&amp;h=647148840&amp;u=https%3A%2F%2Flilly.mediaroom.com%2F2024-05-24-Lilly-Increases-Manufacturing-Investment-to-9-Billion-at-Newest-Indiana-Site-to-Boost-API-Production-for-Tirzepatide-and-Pipeline-Medicines&amp;a=additional+%245.3+billion" rel="noreferrer noopener">additional&nbsp;$5.3 billion</a> commitment to enhance its capacity to manufacture active pharmaceutical ingredients for its latest diabetes and obesity medicines, marking the largest single investment in active pharmaceutical ingredients production in U.S. history.
Opening in late 2027, the facility will increase Lilly&#8217;s total capital commitment in&nbsp;the United States&nbsp;to more than&nbsp;$23 billion&nbsp;since 2020. It is trying to stay ahead of its close competitor, Novo Nordisk A/S&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>).
Once fully operational, the Medicine Foundry is expected to add 400 full-time jobs.
Price Action: At last check on Wednesday, LLY stock was down 0.39% at $881.00 during the premarket session.
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Photo via Shutterstock

Eli Lilly Invests $4.5B In New Medicine Foundry for Advanced Drug Manufacturing To Push US Pharma Boundaries

U.S. Pharmaceutical giant Eli Lilly And Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) is riding high on the popularity of weight loss drugs and is on the brink of becoming the world's first trillion-dollar pharmaceutical company.
According to data from <a target="_blank" href="https://www.benzinga.com/pro/feature/newsfeed" rel="noreferrer noopener">Benzinga Pro</a>, the company's market cap stood at $796.4 billion, and its enterprise value at $821.9 billion.
The stock had almost doubled since May 2022 and outpaced S&amp;P500 and NASDAQ when the company received FDA approval for Mounjaro (tirzepatide) as an adjunct to diet and exercise <a target="_blank" href="https://www.benzinga.com/general/biotech/22/05/27213975/fda-approves-eli-lillys-new-type-2-diabetes-treatment-tirzepatide" rel="noreferrer noopener">for type 2 diabetes</a>.
<figure class="wp-block-image size-full"><img loading="lazy" decoding="async" width="750" height="650" src="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02064204/newplot-1-1.png" alt="" class="wp-image-576166" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02064204/newplot-1-1.png 750w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02064204/newplot-1-1-300x260.png 300w" sizes="(max-width: 750px) 100vw, 750px" /></figure>
In November, the FDA approved tirzepatide, dubbed Zepbound, <a target="_blank" href="https://www.benzinga.com/general/biotech/23/11/35680340/weight-loss-drug-competition-fda-approves-expanded-use-of-eli-lillys-blockbuster-tirzepatide-for-" rel="noreferrer noopener">for weight loss</a>.
In a Financial Times <a target="_blank" href="https://www.ft.com/content/ed81ca79-1fd6-48ea-8e50-246d0849c3f5" rel="noreferrer noopener">report</a>, CEO Dave Ricks recalls a time when Eli Lilly was struggling. In the late 2000s, the loss of patents on its psychiatric drugs, including Prozac and Cymbalta, pushed the company near all-time lows.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/10/41118751/eli-lilly-eyes-new-trials-for-weight-loss-drugs-in-non-obese-patients" rel="noreferrer noopener">Eli Lilly Eyes New Trials For Weight-Loss Drugs In Non-Obese Patients</a>.
<figure class="wp-block-image size-full"><img loading="lazy" decoding="async" width="750" height="650" src="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02064215/newplot-2.png" alt="" class="wp-image-576167" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02064215/newplot-2.png 750w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/10/02064215/newplot-2-300x260.png 300w" sizes="(max-width: 750px) 100vw, 750px" /></figure>
However, the company's fortunes have since reversed, with Eli Lilly now investing $20 billion in production facilities to meet the growing demand for its blockbuster drugs, and it is trying to stay ahead of its close competitor Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>).
The company is also developing orforglipron, which could be the first small-molecule weight-loss pill when it launches in 2026, giving Eli Lilly a two-year lead before rivals catch up.
However, investors are cautious, noting that Eli Lilly's valuation is lofty, currently at $842 billion, 54x projected earnings over the next 12 months.
A top-10 shareholder of Eli Lilly told the Financial Times that investors are rushing into Eli Lilly, pushing it higher, but it's already priced for perfection. The shareholder warned that investors could face significant risks if concerns arise about competition from the ten other companies with weight-loss drugs or potential pricing pressures.
The company aims to strengthen its standing as one of the top 10 most valuable firms in the U.S. by outpacing its competitors.
Eli Lilly plans to reinvest its revenues into R&amp;D, aiming to escape the pharmaceutical industry's traditional boom-and-bust cycle.
CEO Ricks says the company is preparing for the future, particularly as it nears a "patent cliff" for its weight-loss drugs in the mid-2030s. By then, competition and pricing pressure could significantly affect profits.
The company is working on new treatments for obesity-related conditions, such as sleep apnea and cardiovascular disease, which could secure broader insurance coverage for its drugs.
Price Action: LLY stock closed at $884.55&nbsp;on Tuesday.
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Photo via Eli Lilly and Company

Eli Lilly Nears First Trillion Dollar Pharma Title, But Investors Caution Amid Sky-High Valuation

Monday, the U.S. Department of Health and Human Services (HHS) announced that Medicare enrollees will benefit from reduced prices on 54 drugs through Medicare Part B, effective from October 1, 2024, to December 31, 2024.
The <a target="_blank" href="https://www.hhs.gov/about/news/2024/09/30/hhs-announces-cost-savings-for-prescription-drugs-thanks-to-medicare-inflation-rebate-program.html" rel="noreferrer noopener">program</a> aims to counter drug price hikes that exceed inflation, providing financial relief for over 822,000 Medicare beneficiaries who rely on these medications to treat conditions like cancer, osteoporosis, and pneumonia.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/08/40422798/doctors-struggle-to-secure-medicare-coverage-for-heart-patients-on-novo-nordisks-wegovy" rel="noreferrer noopener">Doctors Struggle to Secure Medicare Coverage for Heart Patients on Novo Nordisk&#8217;s Wegovy</a>
HHS Secretary Xavier Becerra emphasized that the Biden administration&#8217;s prescription drug policies are making a tangible impact on seniors and people with disabilities by reducing out-of-pocket costs.
According to Chiquita Brooks-LaSure, CMS Administrator, some Medicare beneficiaries could see daily savings ranging from $1 to as much as $3,854 on drugs included in the rebate program.
For example, a cancer patient using Novartis&#8217; AGs (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVS#NYSE">NVS</a>) Kymriah could save up to $3,000.
Brooks-LaSure also noted that the law disincentivizes drug companies from raising prices faster than inflation, which helps protect Medicare beneficiaries from sharp price increases.
The Inflation Reduction Act&#8217;s initiatives extend beyond 2024. In August, the administration reached new agreements to reduce prices for ten additional high-cost drugs.
Once these prices take effect in 2026, Medicare is projected to save an estimated $6 billion, while beneficiaries could see a reduction of $1.5 billion in <a target="_blank" href="https://www.benzinga.com/general/biotech/24/08/40397706/biden-administration-targets-6b-savings-through-medicare-drug-price-negotiations" rel="noreferrer noopener">out-of-pocket expenses</a>.
Starting in 2025, Medicare Part D enrollees will further benefit from a $2,000 annual cap on prescription drug costs, down from the current cap of $3,500 for those with high expenses.
According to some analysts,&nbsp;Novo Nordisk A/S&#8217; (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>)&nbsp;blockbuster diabetes drug&nbsp;Ozempic might be included, along with several other well-known medications, in the next round of negotiations, which <a target="_blank" href="https://www.benzinga.com/general/biotech/24/08/40534249/novo-nordisks-ozempic-might-be-among-2027-medicare-price-negotiation-targets" rel="noreferrer noopener">is set for 2027</a>.
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Regulations

US HHS Reveal Cost Savings For 54 Prescription Drugs Including Novartis' Cancer Drug, Ozempic Could be Next

Novo Nordisk Says Co Has Mitigation Plans In Place To Minimize Or Prevent Any Production Disruption Due To The Potential Seaport Strikes

At its Pharma Day, Swiss pharmaceutical giant Roche Holdings AG (OTC:<a class="ticker" href="https://www.benzinga.com/stock/RHHBY#OTC">RHHBY</a>) outlined five priority therapeutic areas: neurology, oncology and hematology, immunology, ophthalmology, and cardiovascular, renal, and metabolism diseases.
The company shared an &#8216;initial set of assets designated for acceleration based on exceptional potential.&#8217;
To maximize potential, the company plans to expedite enrollment with additional clinical trial sites, reallocate resources, and expand into additional indications.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/08/40422774/roche-misses-out-on-weight-loss-blockbuster-drug-now-playing-catch-up-in-booming-market" rel="noreferrer noopener">Roche Misses Out On Weight-Loss Blockbuster Drug, Now Playing Catch-Up In Booming Market</a>.
The <a target="_blank" href="https://assets.roche.com/f/176343/x/f513f69de2/pharma_day_20240930_final_online_v02.pdf" rel="noreferrer noopener">selected</a> fast-tracked programs include:
<ul>
<li>CT-388 (RG6640) for obesity entered the Phase 2 stage of development in patients with or without type 2 diabetes and comorbidities.</li>
<li>Roche expects a commercial launch for CT-388 beyond 2028.</li>
<li>Trontinemab is currently in Phase 2 for Alzheimer&#8217;s. Potential launch in 2025-2028.</li>
<li>Anti-TL1A Inflammatory Bowel Disease candidate in Phase 3 stage of development.</li>
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Roche&#8217;s push into the obesity space follows the success of competitors like Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) and Eli Lilly And Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), which have seen significant demand for weight-loss drugs like Wegovy and Zepbound.
Additionally, Roche highlighted the financial potential of its obesity drug candidates, projecting that <a target="_blank" href="https://www.benzinga.com/general/biotech/23/12/36064233/roche-joins-bandwagon-to-challenge-novo-nordisk-eli-lilly-for-weight-loss-drugs" rel="noreferrer noopener">early-stage assets acquired</a> from Carmot Therapeutics (CT-388/CT-996/CT-868) could generate over 3 billion Swiss francs ($3.55 billion) in annual sales.
In July, Roche&nbsp;announced topline results from two arms of an ongoing multi-part Phase 1 clinical trial for CT-996 for&nbsp;<a target="_blank" href="https://www.benzinga.com/general/biotech/24/07/39817857/obesity-drugs-focused-stocks-tumble-on-wednesday-whats-going-on-with-eli-lilly-novo-nordisk-vikin" rel="noreferrer noopener">type 2 diabetes and obesity</a>.
The data showed that treatment with CT-996 in participants with obesity and without type 2 diabetes resulted in a clinically meaningful placebo-adjusted mean weight loss of -6.1% within four weeks.
In line with its broader strategy, Roche plans to cut drug development costs by 20% and reduce the time it takes for drugs to move from discovery to the end of Phase 3 trials by 40%, aiming to launch 20 transformative medicines by 2030.
The company is targeting three times as many patients during the 2020-2029 period.
Monday, Roche <a target="_blank" href="https://www.prnewswire.com/news-releases/regor-enters-into-a-definitive-purchase-agreement-for-genentech-to-acquire-regors-portfolio-of-next-generation-cdk-inhibitors-for-the-treatment-of-breast-cancer-302262174.html" rel="noreferrer noopener">agreed</a> to acquire a portfolio of next-generation CDK inhibitors for breast cancer from Regor Pharmaceuticals.
Regor will receive an upfront cash payment of&nbsp;$850 million&nbsp;and is eligible for additional milestone cash payments.
Roche&#8217;s Genentech will be responsible for clinical development, manufacturing, and commercialization worldwide.
Regor will continue to manage the two ongoing Phase 1 trials to their completion.
The deal is expected to close in the fourth quarter of 2024.
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Eurozone

RHHBY

Roche Fast-Tracks Obesity Drug Development, Eyes Over $3B Sales Potential

In a surprising twist, two of the most unlikely allies – billionaire Elon Musk and Sen. Bernie Sanders – are standing together on one issue: the high cost of health care in America. Both agree that Americans are being charged way too much for <a href="https://www.benzinga.com/markets/cannabis/24/09/41033009/can-novo-nordisks-weight-loss-drug-ozempic-help-stem-the-devastating-addiction-crisis-new-resear">essential medications like Ozempic</a> and Wegovy, which treat diabetes and obesity.
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Bernie Sanders, a longtime advocate for affordable health care, has been vocal about Novo Nordisk (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>), the Danish company behind these drugs, charging American patients almost 10 times more than they charge in other countries like Germany.
<a href="https://www.benzinga.com/general/biotech/24/09/41010577/novo-nordisk-to-consider-ways-for-patients-to-affordably-access-weight-loss-drugs-ozempic-wegovy-">A month's prescription for Wegovy</a> costs $1,349 in the U.S., compared to $186 in Denmark, $140 in Germany, and $92 in the U.K.
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During a recent subcommittee hearing, Sanders called out Novo Nordisk&#8217;s CEO and demanded that Americans be treated fairly. "All we are saying, Mr. Jørgensen, is treat the American people the same way that you treat people all over the world – stop ripping us off."
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">&#x1f6a8;&#x1f1fa;&#x1f1f8;SEN. BERNIE SANDERS: ELON IS RIGHT ABOUT SOLVING OBESITY &quot;Elon Musk, not one of my usual allies, recently tweeted that solving obesity reduces the risk of diseases like diabetes and improves quality of life. He's right—we need to make appetite inhibitors available to… <a href="https://t.co/vmPzNNc15B">pic.twitter.com/vmPzNNc15B</a>
&mdash; Mario Nawfal (@MarioNawfal) <a href="https://twitter.com/MarioNawfal/status/1838737435653460028?ref_src=twsrc%5Etfw">September 25, 2024</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
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Elon Musk, known for his clashes with Sanders over income inequality, surprised many by siding with the senator. He shared his struggles with weight and revealed he had used Wegovy to help him slim down.&nbsp;
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"Solving obesity greatly reduces the risk of other diseases, especially diabetes, and improves quality of life," Sanders quoted Musk as saying. And Musk followed up with, "I really am with Bernie on this one."
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">I really am with Bernie on this one
&mdash; Elon Musk (@elonmusk) <a href="https://twitter.com/elonmusk/status/1838758206585094625?ref_src=twsrc%5Etfw">September 25, 2024</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
Novo Nordisk's CEO, Lars Fruergaard Jørgensen, admitted that a huge chunk of the company's revenue from these drugs comes from the U.S., but he tried to shift the blame to PBMs, who he says pocket 74 cents of every dollar made. This system, he argued, keeps prices high because PBMs get paid more when the list price is higher.
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Sanders wasn't buying it. He revealed that he had gotten a written promise from three major PBMs that they wouldn't drop coverage for Novo Nordisk's drugs if the company lowered its prices. But Jørgensen acted surprised and claimed he hadn't heard of any such deal.
The Federal Trade Commission (FTC) also released a <a href="https://www.ftc.gov/system/files/ftc_gov/pdf/pharmacy-benefit-managers-staff-report.pdf">report</a> highlighting how pharmacy benefit managers (PBMs) are profiting at the expense of patients. These middlemen, who manage prescription drug benefits for insurers and employers, have been inflating drug prices and squeezing independent pharmacies.&nbsp;
According to a report, six major corporations manage about 90% of all prescriptions in the United States. This gives them the authority to set exorbitant medicine costs. Because of the high expense of prescription drugs, almost 30% of Americans have reported skipping dosages or limiting them.
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FTC Chair Lina M. Khan stated that the report &#8220;Details how PBMs can squeeze independent pharmacies that many Americans – especially those in rural communities – depend on for essential care. The FTC will continue using all our tools and authorities to scrutinize dominant players across health care markets and ensure Americans can access affordable health care.&#8221;
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Mark Cuban, another billionaire entrepreneur and owner of Cost Plus Drugs, quickly responded to the FTC's findings. In a tweet, <a href="https://www.benzinga.com/personal-finance/24/07/39799717/patients-pay-the-price-as-drug-middlemen-profit-says-ftc-report-mark-cubans-take-anyone-surprise">he pointed out the obvious</a>: "Anyone surprised by this? Please share with every CEO, CFO, and HR person you know. If you are a shareholder or Wall Street analyst, ask your portfolio companies who their PBM is, not if they are being ripped off, but how badly."
In a country where health care costs are sky-high and outcomes lag behind many other developed nations, it's rare to see such agreement across the political spectrum. But when both a billionaire tech mogul and a democratic socialist senator are on the same side, it might be time to take notice.
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Personal Finance

'Stop Ripping Us Off' – Incredibly, Elon Musk And Bernie Sanders Seem To Agree On This One Thing – 'I Really Am With Bernie On This One'

Benzinga examined the prospects for <a href="http://www.benzinga.com/trading-ideas">many investors&#8217; favorite stocks</a> over the last week — here&#8217;s a look at some of our top stories.
The Dow Jones Industrial Average hit a record high Friday as investors analyzed data showing continued progress in lowering inflation. Wall Street posted its third straight week of gains.
The S&amp;P 500 and Dow both rose about 0.6% for the week, while the Nasdaq climbed nearly 1%. The personal consumption expenditures index, the Federal Reserve&#8217;s preferred inflation measure, increased 2.2% in August compared to the previous year, coming in below economists&#8217; expectations. 
This followed the Federal Reserve&#8217;s 0.5% interest rate cut on Sept. 18, the first in <a href="https://www.benzinga.com/markets/equities/24/09/41074448/latest-inflation-data-cements-feds-interest-rate-call-s-p-500-hits-all-time-high-biden-adviser-b">more than four years</a>.
Benzinga provides daily reports on the stocks most popular with investors. Here are a few of this past week&#8217;s most bullish and bearish posts that are worth another look.
<h3 class="wp-block-heading">The Bulls</h3>
&#8220;<a href="https://www.benzinga.com/news/24/09/41005053/apple-iphone-to-fuel-96-of-2025-revenue-analyst-says-a-safer-bet-than-ai-heavy-amazon-alphabet-micro">Apple iPhone To Fuel 96% Of 2025 Revenue, Analyst Predicts: A Safer Bet Than AI-Heavy Amazon, Alphabet, Microsoft, Meta?</a>&#8221; by <a href="https://www.benzinga.com/author/anusuya-lahiri-0">Anusuya Lahiri</a>, highlights an analyst&#8217;s projection that Apple Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>) will derive 96% of its 2025 revenue from iPhone sales, positioning it as a safer investment than AI-focused giants like Amazon.com Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMZN#NASDAQ">AMZN</a>), Alphabet Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GOOG#NASDAQ">GOOG</a>) (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GOOGL#NASDAQ">GOOGL</a>), Microsoft Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MSFT#NASDAQ">MSFT</a>), and Meta Platforms Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/META#NASDAQ">META</a>).
&#8220;<a href="https://www.benzinga.com/markets/cryptocurrency/24/09/41059326/shiba-inu-soars-29-on-shi-stablecoin-update-lead-developer-shytoshi-kusama-teases-breakout">Shiba Inu Soars 29% On SHI Stablecoin Update: Lead Developer Shytoshi Kusama Teases Breakout</a>,&#8221; by <a href="https://www.benzinga.com/author/aniket-verma">Aniket Verma</a>, reports that Shytoshi Kusama teased the impending launch of the SHI stablecoin, which is seen as a crucial development for Shibarium, sparking excitement across the Shiba Inu (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/shib/usd">SHIB</a>) ecosystem.
&#8220;<a href="https://www.benzinga.com/general/biotech/24/09/41034046/popular-ozempic-may-have-new-use-as-semaglutide-drugs-linked-to-reduced-overdose-risk-in-diabetic">Popular Ozempic May Have New Use As Semaglutide Drugs Linked To Reduced Overdose Risk In Diabetic Opioid Users</a>,&#8221; by <a href="https://www.benzinga.com/author/vandana-singh">Vandana Singh</a>, reports that a new study found Novo Nordisk A/S&#8216;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) semaglutide, sold as Ozempic and Wegovy, may lower the risk of opioid overdose in patients with both type 2 diabetes and opioid use disorder.
For additional bullish calls of the past week, check out the following:
<a href="https://www.benzinga.com/general/education/24/09/41031059/after-fed-rate-cuts-is-tesla-nvidia-apple-or-amazon-the-best-investment-poll-reveals-top-magnif">After Fed Rate Cuts, Is Tesla, Nvidia, Apple, Or Amazon The Best Investment? Poll Reveals Top Magnificent 7 Stock</a>
<a href="https://www.benzinga.com/news/24/09/41034882/billionaire-tech-ceo-makes-cameo-in-zuckerbergs-meta-connect-show">Billionaire Tech CEO Makes Cameo In Zuckerberg&#8217;s Meta Connect Show</a>
<a href="https://www.benzinga.com/markets/equities/24/09/41023892/palantir-and-apa-amp-up-ai-alliance-multi-million-dollar-deal-to-transform-oil-gas-operations">Palantir And APA Amp Up AI Alliance: Multi-Million Dollar Deal To Transform Oil &amp; Gas Operations</a>
The Bears
&#8220;<a href="https://www.benzinga.com/analyst-ratings/analyst-color/24/09/40995280/tesla-bull-dampens-enthusiasm-regarding-1010-robotaxi-event-but-heres-what-would-ta">Tesla Bull Dampens Enthusiasm Regarding 10/10 Robotaxi Event But Here&#8217;s What Would Take To Strengthen Fledgling Stock Recovery</a>,&#8221; by <a href="https://www.benzinga.com/author/shanthi-rexaline">Shanthi Rexaline</a>, covers Gary Black&#8216;s skepticism about Tesla Inc&#8216;s (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>) upcoming Robotaxi event as a stock catalyst, while highlighting optimism for a potential sub-$30K compact EV launch that could drive long-term growth for Tesla.
&#8220;<a href="https://www.benzinga.com/news/24/09/41016947/crowdstrike-executive-struck-by-regret-in-house-hearing-says-company-determined-to-prevent-instances">CrowdStrike Executive Struck By Regret In House Hearing, Says Company Determined To Prevent Instances Like Microsoft Outage From Repeating</a>,&#8221; by <a href="https://www.benzinga.com/author/ananya-gairola">Ananya Gairola</a>, reports Adam Meyers of CrowdStrike Holdings Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CRWD#NASDAQ">CRWD</a>) apologized to lawmakers for the July global outage caused by a faulty update affecting systems running Microsoft software, promising to prevent future occurrences.
&#8220;<a href="https://www.benzinga.com/markets/cryptocurrency/24/09/41059769/peter-schiff-wants-to-know-if-bitcoin-fans-really-care-about-king-crypto-underperforming-g">Peter Schiff Wants To Know If Bitcoin Fans Really Care About King Crypto Underperforming Gold</a>,&#8221; by <a href="https://www.benzinga.com/author/aniket-verma">Aniket Verma</a>, highlights Peter Schiff&#8216;s critique of Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) investors for ignoring its 35% decline against gold since November 2021, despite significant media hype and interest in the cryptocurrency.
For more bearish takes, be sure to see these posts:
<a href="https://www.benzinga.com/analyst-ratings/analyst-color/24/09/41000698/a-deflationary-nuclear-bomb-is-ticking-warns-economist-even-as-inflation-risks-wane">A &#8216;Deflationary Nuclear Bomb&#8217; Is Ticking, Warns Economist, Even As Inflation Risks Wane: &#8216;Cheaper It Gets, Cheaper Everything Gets&#8217;</a>
<a href="https://www.benzinga.com/trading-ideas/long-ideas/24/09/41049089/treasury-bond-etf-under-pressure-ahead-of-key-inflation-data-what-investors-should-know">Treasury Bond ETF Under Pressure Ahead Of Key Inflation Data: What Investors Should Know</a>
<a href="https://www.benzinga.com/markets/equities/24/09/41053761/american-eagle-sues-amazon-for-trademark-infringement-report">American Eagle Sues Amazon for Trademark Infringement: Report</a>
Keep up with all the latest breaking news and trading ideas by following<a href="https://twitter.com/Benzinga"> Benzinga</a><a href="http://twitter.com/Benzinga"> on Twitter</a>.
Image created using artificial intelligence via Midjourney.

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Benzinga Bulls And Bears: Apple, Tesla, Novo Nordisk, Bitcoin — And Shiba Inu's Major Stablecoin Tease

The Federal Reserve's preferred measure of inflation, the personal consumption expenditures index, grew less than economists expected in August at 2.2% <a href="https://www.benzinga.com/news/econ-s/24/09/41066122/feds-preferred-inflation-gauge-comes-in-below-expectations-for-august-easing-concerns-about-rising-p">year-over-year</a>. The data comes on the heels of the Federal Reserve's 0.5% interest rate cut issued Sept. 18, the first in <a href="https://www.benzinga.com/economics/macro-economic-events/24/09/40926026/federal-reserve-delivers-bold-0-5-rate-cut-signals-further-easing-ahead">more than four years</a>.&nbsp;
The inflation data supports another 0.5% interest rate cut in November, RSM US LLP Chief Economist Joseph Brusuelas said in a Friday tweet. "This is what an economic expansion looks like at full employment," <a href="https://www.benzinga.com/news/24/09/41068393/inflation-decline-strengthens-confidence-in-feds-interest-rate-cut-if-you-were-second-guessing-the-f">he said</a>.&nbsp;
The S&amp;P 500 traded at all-time highs above the 5,700 level <a href="https://www.benzinga.com/markets/equities/24/09/41029448/s-p-500-hits-all-time-highs-nasdaq-100-tops-20k-ahead-of-key-economic-data-whats-driving-markets">this week</a>.
<h1 class="wp-block-heading">Brainard Touts China EV Ban In Detroit</h1>
Lael Brainard, the director of the National Economic Council and a former Federal Reserve board member, spoke in favor of the Biden administration's proposed ban on Chinese electric vehicles Monday at the Detroit Economic Club, the same day <a href="https://www.benzinga.com/markets/asia/24/09/40981254/chinese-vehicle-tech-faces-biden-administration-ban-over-national-security-concerns-china-ev-stocks">details of the proposal</a> were released. The U.S. Commerce Department aims to block the import and sale of Chinese-made vehicles with key communications and automated driving systems on the basis of national security concerns. Additionally, a 100% tariff on Chinese electric vehicles imposed by the Biden administration took effect Friday. 
"We will not allow cars driving on U.S. roads if they are using Chinese software and hardware systems," Brainard <a href="https://www.benzinga.com/markets/asia/24/09/40987608/biggest-risk-for-us-autos-biden-advisor-outlines-steps-to-counter-chinese-influence-on-the-industry">told the DEC</a>. "We think this is very important from a national security point of view."
<h1 class="wp-block-heading">Meta Platforms Dives Deeper Into AI, Virtual Reality</h1>
Facebook parent company Meta Platforms Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/META#NASDAQ">META</a>) announced its latest Quest 3S virtual reality headset at the Meta Connect 2024 conference Wednesday along with updates to its Llama artificial intelligence platform and Ray-Ban smart glasses. CEO Mark Zuckerberg introduced a prototype for Orion, Meta's holographic <a href="https://www.benzinga.com/news/24/09/41032461/meta-unveils-new-ai-features-quest-3s-llama-3-2-holographic-orion-glasses-at-connect-2024-we-are-get">augmented reality glasses</a>. 
"This isn't passthrough. This is the physical world with holograms laid on it," Zuckerberg said.
<h1 class="wp-block-heading">China's Stimulus Triggers Stock Rally</h1>
The People's Bank of China announced <a href="https://www.benzinga.com/markets/asia/24/09/41003814/chinese-stocks-jump-as-central-bank-unveils-major-stimulus-to-spur-economy-a-step-in-the-right-direc">stimulus measures this week</a> that will inject approximately $140 billion (1 trillion yuan) in liquidity into the country's banking system as well as a reduction in the mortgage rate, sending U.S.-traded China stocks and ETFs such as e-commerce giant Alibaba Group Holding Ltd &#8211; ADR (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BABA#NYSE">BABA</a>) and electric vehicle manufacturer Nio Inc &#8211; ADR (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NIO#NYSE">NIO</a>) higher. 
Billionaire hedge fund manager David Tepper told CNBC's "Squawk Box" that he's building <a href="https://www.benzinga.com/trading-ideas/long-ideas/24/09/41050711/stocks-rise-as-china-signals-more-stimulus-billionaire-david-tepper-bets-big-on-everythi">positions in Chinese stocks</a>. "I didn't know that they were going to bring out the big guns," Tepper of the country's stimulus plans.&nbsp;
<h1 class="wp-block-heading">Bernie Sanders Blasts Ozempic Cost</h1>
Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) CEO Lars Jorgensen faced questions from the Senate Health, Education, Labor and Pensions Committee Tuesday about the high prices of the drugs Ozempic and Wegovy. 
Wegovy, the weight loss version of diabetes drug Ozempic, costs $1,349 monthly in the U.S. versus $186 in Denmark, $140 in Germany and $92 in the U.K., according to the committee.
"You're making huge amounts of money in this country and you're charging us far more and you haven't given me an answer as to why," Sen. Bernie Sanders, the committee's chair, said to Jorgensen during the hearing.
The CEO said: "Anything that will help patients get access to affordable medicine, we'll be happy to look into."
Photo: Shutterstock.

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Latest Inflation Data Cements Fed's Interest Rate Call, S&P 500 Hits All-Time High, Biden Adviser Backs China EV Ban At Detroit Economic Club: This Week In The Markets

Novo Nordisk (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) has outperformed the market over the past 5 years by 22.36% on an annualized basis producing an average annual return of 36.66%. Currently, Novo Nordisk has a market capitalization of $536.41 billion. 
Buying $1000 In NVO: If an investor had bought $1000 of NVO stock 5 years ago, it would be worth $4,660.74 today based on a price of $120.51 for NVO at the time of writing.
<h3>Novo Nordisk's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1727456441_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

If You Invested $1000 In This Stock 5 Years Ago, You Would Have $4,700 Today

U.S. stock futures were slightly lower this morning, with the Nasdaq futures falling around 0.2% on Friday.
Shares of Cassava Sciences, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SAVA#NASDAQ">SAVA</a>) fell sharply in today's pre-market trading after the SEC charged the company, two former executives for misleading claims about <a href="https://www.benzinga.com/quote/SAVA/news">Alzheimer&#8217;s clinical trial</a>.
Cassava Sciences shares dipped 10.8% to $28.40 in pre-market trading.
Here are some big stocks recording losses in today's pre-market trading session.
<ul>
<li>enVVeno Medical Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVNO#NASDAQ">NVNO</a>) shares tumbled 16.4% to $3.7600 in pre-market trading after the company announced a proposed public offering.</li>
<li>Uranium Energy Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UEC#NYSE">UEC</a>) shares declined 5% to $6.05 in pre-market trading.</li>
<li>Udemy Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/UDMY#NASDAQ">UDMY</a>) shares fell 4.6% to $7.76 in pre-market trading.</li>
<li>TORM plc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TRMD#NASDAQ">TRMD</a>) shares declined 4% to $33.96 in pre-market trading.</li>
<li>HP Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HPQ#NYSE">HPQ</a>) shares declined 3.2% to $35.70 in pre-market trading after gaining over 2% on Thursday.</li>
<li>Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) shares fell 2.6% to $121.05 in pre-market trading.</li>
</ul>
Now Read This: 
<ul>
<li><a href="https://www.benzinga.com/news/earnings/24/09/41061540/s-p-hits-new-record-high-following-economic-reports-investor-optimism-improves-further-fear-index-r">S&amp;P Hits New Record High Following Economic Reports: Investor Optimism Improves Further, Fear Index Remains In &#8216;Greed&#8217; Zone</a></li>
</ul>

NVNO

SAVA

TRMD

UDMY

Cassava Sciences, enVVeno Medical And Other Big Stocks Moving Lower In Friday's Pre-Market Session

On Thursday, Evotec SE (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EVO#NASDAQ">EVO</a>) entered a technology development partnership with Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) <a target="_blank" href="https://www.benzinga.com/pressreleases/24/09/ac41039378/evotec-and-novo-nordisk-enter-into-technology-development-partnership-to-support-next-generation-" rel="noreferrer noopener">in cell therapy</a>.
Evotec and Novo Nordisk have significant expertise and a strategic focus on supporting stem cell-based therapies.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/06/39419032/german-drug-developer-evotec-seeks-adviser-input-as-takeover-concerns-mount" rel="noreferrer noopener">German Drug Developer Evotec Seeks Adviser Input As Takeover Concerns Mount</a>.
To provide next-generation off-the-shelf cell therapy products for clinical development and possible commercialization, the companies will collaborate on developing advanced technologies in support thereof.
Under the collaboration agreement, Novo Nordisk will fund technology development activities at Evotec's R&amp;D site in Göttingen, Germany and at Evotec's certified cell therapy manufacturing facility in Modena, Italy.
Novo Nordisk has the option to obtain exclusive rights to utilize the results of the collaboration for a pre-defined therapeutic area.
Evotec receives R&amp;D funding, an undisclosed upfront, and possible milestone and royalty payments.
Cord Dohrmann, Chief Scientific Officer of Evotec, said: "Cell therapies have already proven to be highly effective and have the potential to become functional cures in many disease areas. Stem cell-based cell therapy is a promising approach to modulate and scale cell therapies to ultimately provide tailor-made, off-the-shelf cell therapies at reasonable costs."
Citing Sydbank analysts, Reuters noted that Novo Nordisk's stem cell-based therapies for diabetes and cardiovascular diseases are still in the exploratory phase, and the collaboration with Evotec aims to unlock this potential further.
Reuters also highlighted Warburg Research analyst who suggested the partnership could be tied to Evotec's beta-cell implant program QR-Beta, with the initial upfront payment likely covering capacity, manpower, and a cost margin.
Price Action: EVO stock is up 4.80% at $3.49 at last check Thursday.
Read Next:
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<li><a href="https://www.benzinga.com/news/earnings/24/09/41046485/whats-going-on-with-nvidia-braodcom-intel-and-other-chip-stocks-on-thursday" target="_blank" rel="noreferrer noopener">What's Going On With Nvidia, Broadcom, Intel, And Other Chip Stocks On Thursday?</a></li>
</ul>
Image via Evotec

Contracts

Novo Nordisk And Evotec Collaborate On Stem Cell-Based Therapy Development

On Thursday, Vivani Medical, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VANI#NASDAQ">VANI</a>) announced that the Bellberry Human Research Ethics Committee has approved, and the Therapeutic Goods Administration in Australia has formally acknowledged a first-in-human clinical trial of the company's miniature, subdermal GLP-1 (exenatide) implant in obese and overweight subjects.
What Happened: "Securing regulatory approval keeps us on schedule to initiate this trial in Australia in the fourth quarter of 2024," said Vivani President and CEO Adam Mendelsohn.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/07/39726263/exclusive-vivani-medical-outlines-plans-to-kickstart-first-clinical-study-for-miniature-glp-1-obe" rel="noreferrer noopener">EXCLUSIVE: Vivani Medical Outlines Plans To Kickstart First Clinical Study For Miniature GLP-1 Obesity Implant Program This Year</a>.
LIBERATE-1 will be a randomized investigation of the safety, tolerability, and pharmacokinetic profile of the exenatide NanoPortal implant in obese or overweight subjects.
The trial will enroll participants who will be titrated on weekly semaglutide injections for 8 weeks (0.25 mg/week for 4 weeks followed by 0.5 mg/week for 4 weeks) before being randomized to receive a single administration of Vivani's exenatide implant (n=8), weekly exenatide injections (n=8), or weekly 1 mg semaglutide injections (n=8) for 9-week treatment duration.
Weight changes will be measured. The trial is expected to be initiated later this year, and data is projected to be available in 2025.
Why It Matters: "Preclinical <a target="_blank" href="https://www.benzinga.com/general/biotech/24/09/40704367/exclusive-vivani-medical-reveals-positive-preclinical-liver-fat-results-from-miniature-glp-1-impl" rel="noreferrer noopener">weight loss and liver fat data</a> announced earlier this year supports the potential for our GLP-1 implant to provide comparable efficacy to semaglutide, the active ingredient in blockbuster products Ozempic and Wegovy, but with the significant benefit of twice-yearly administration," Mendelsohn added.
Ozempic and Wegovy are registered trademarks of Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>).
If available, Vivani intends to utilize research and development incentives and rebates from the Australian government to defray a portion of the costs from the trial.
Since clinical studies conducted in Australia comply with the International Conference on Harmonization guidelines and data generated in Australia are generally acceptable to the FDA and other regulatory authorities, Vivani anticipates using relevant clinical data generated in Australia to support regulatory submissions in other geographies, including the U.S.
Price Action: VANI stock closed at $1.18 on Wednesday.
Read Next:
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<li><a href="https://www.benzinga.com/general/biotech/24/09/41033979/fda-casts-doubt-on-use-of-merck-bristol-myers-pd-1-cancer-drugs-for-certain-type-of-gastric-cance" target="_blank" rel="noreferrer noopener">FDA Casts Doubt On Use Of Merck, Bristol Myers' PD-1 Cancer Drugs For Certain Type Of Gastric Cancer Patients</a>.</li>
</ul>

EXCLUSIVE: Vivani Medical Advances Its Obesity Treatment Implant With New Clinical Trial in Australia

Some experts believe Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) products not only help people lose weight and control diabetes, they can help treat the <a href="https://www.benzinga.com/markets/cannabis/24/09/41033009/can-novo-nordisks-weight-loss-drug-ozempic-help-stem-the-devastating-addiction-crisis-new-resear">country&#8217;s addiction crisis.</a> 
The Novo Nordisk chart illustrates two common technical analysis dynamics that <a href="https://www.benzinga.com/quote/NVO">successful traders can use to profit.</a>
As you can see, the $123 level was support for the stock in April. Then it was support again in early August. And after a recent move higher and a reversal, the stock found support around the same level again.
Support can stay intact for an extended time because of investor and trader psychology. It is because there are traders who sold while the stock was at support. But right after they were done selling, the shares rallied.
When this happened, many of these sellers came to regret their decision to get rid of their shares. Some of them decided to buy their shares back. But, they will only do so if they can buy the shares for the same price they were sold.
<figure class="wp-block-image size-full"><img loading="lazy" decoding="async" width="979" height="603" src="https://editorial-assets.benzinga.com/wp-content/uploads/2024/09/25173834/1-26.png" alt="" class="wp-image-566523" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2024/09/25173834/1-26.png 979w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/09/25173834/1-26-300x185.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/09/25173834/1-26-768x473.png 768w" sizes="(max-width: 979px) 100vw, 979px" /></figure>
Read Also:<a href="https://www.benzinga.com/general/biotech/24/09/41034046/popular-ozempic-may-have-new-use-as-semaglutide-drugs-linked-to-reduced-overdose-risk-in-diabetic"> Popular Ozempic May Have New Use As Semaglutide Drugs Linked To Reduced Overdose Risk In Diabetic Opioid Users</a>
So, when the stock reversed and eventually returned to the support level, these remorseful sellers placed buy orders. And there were so many of these buy orders that it created support at the level which had been support before.
Seller's remorse&nbsp;can make support levels stay intact for an extended period of time.
When a stock drops to a support level, there is a tendency for them to reverse and rally. This is also because of psychology. It happens because some of the buyers experience anxiety.
These buyers are worried they will miss the trade. They know that the sellers will go to whoever is willing to pay the highest price.
As a result, they increase the prices they are willing to pay. Other anxious buyers see this and do the same thing.
This results in a bidding war that pushes the price higher.
If understood and interpreted correctly, technical analysis is the study of investor and trader psychology. Seller's remorse can cause support levels to stay intact for an extended period of time. Buyer's anxiety can make stocks rally after the drop to support levels.
Read Next: • <a href="https://www.benzinga.com/analyst-ratings/analyst-color/24/09/41028913/bristol-myers-2seventy-bio-halt-phase-3-trial-for-abecma-in-newly-diagnosed-myeloma">Bristol Myers-2seventy Bio Halt Phase 3 Trial For Abecma In Newly Diagnosed Myeloma Patients, Speeds Path To Profitability</a>
Photo: Shuttersotck

Lose Weight With Novo Nordisk Drugs, Gain Money With Stock

A study compared the association of semaglutide vs other antidiabetic medications and other GLP-1RAs, including liraglutide and dulaglutide, with opioid overdose risk in patients with comorbid type 2 diabetes (T2D) and opioid use disorder (OUD).
Novo Nordisk A/S&#8217; (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) semaglutide is available as Wegovy and Ozempic for weight loss and diabetes, respectively, and liraglutide is sold as Saxenda and Victoza.
Also Read: <a target="_blank" href="https://www.benzinga.com/analyst-ratings/analyst-color/24/09/41025381/exclusive-novo-nordisk-faces-political-heat-over-weight-loss-drug-prices-ahead-of-e" rel="noreferrer noopener">EXCLUSIVE: Novo Nordisk Faces Political Heat Over Weight-Loss Drug Prices Ahead Of Elections, Yet &#8216;The Real Issue Is With The Middlemen&#8217;</a>.
Eli Lilly And Co&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) dulaglutide is available as Trulicity.
Drug overdose <a target="_blank" href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824054?guestAccessKey=67ec89b0-a682-4fbf-97d9-1c0054b62d04&amp;utm_source=for_the_media&amp;utm_medium=referral&amp;utm_campaign=ftm_links&amp;utm_content=tfl&amp;utm_term=092524" rel="noreferrer noopener">deaths</a> in the U.S. remain alarmingly high, with an estimated 107,543 fatalities in 2023, primarily due to opioids.
Despite the proven effectiveness of medications for opioid use disorder (OUD) in reducing overdose risk, only about 25% of individuals with OUD receive treatment, and nearly half discontinue it within six months. This highlights the urgent need for alternative OUD therapies.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), commonly used to treat type 2 diabetes and obesity, have been shown to modulate dopamine reward pathways and reduce drug rewards, including heroin, in animal studies.
Additionally, anecdotal reports and studies have suggested that semaglutide may reduce drug cravings and offer therapeutic benefits in alcohol and nicotine use disorders.
These findings prompted an investigation into whether semaglutide could potentially help prevent overdoses in OUD patients.
Semaglutide was associated with a significantly lower risk of opioid overdose during a 1-year follow-up compared with other antidiabetic medications, including other GLP-1RAs, with HRs ranging from 0.32 to 0.58. 
The negative control outcome showed no difference between groups. The update signals a potential new use for the blockbuster diabetes medications.
The researchers noted that results need validation from other data resources and study populations. Further research is warranted to investigate the underlying mechanisms, and randomized clinical trials are necessary to corroborate the clinical effects on OUD.
The study utilized six years of data (between December 2017 and June 2023) from over 33,006 patients.
Earlier this year, a comprehensive U.S. study revealed that the use of&nbsp;Ozempic and Wegovy is not associated with an increased&nbsp;<a target="_blank" href="https://www.benzinga.com/general/biotech/24/01/36509636/novo-nordisks-ozempic-and-wegovy-helps-lose-weight-not-ones-mind-us-study-find-no-increased-suici" rel="noreferrer noopener">risk of suicidal thoughts</a>.
Price Action: NVO stock is up 1.16% at $126.90, and LLY stock is down 0.05% at $924.01 at the last check on Wednesday.
Read Next:
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<li><a href="https://www.benzinga.com/analyst-ratings/analyst-color/24/09/41031132/amgens-rocatinlimab-has-commercial-potential-despite-competitive-landscape-says-gol" target="_blank" rel="noreferrer noopener">Amgen&#8217;s Rocatinlimab Has Commercial Potential Despite Competitive Landscape, Says Goldman Sachs</a>.</li>
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