Regulus Therapeutics Azioni (NASDAQ: RGLS)

Ultime notizie per Regulus Therapeutics (NASDAQ:RGLS) Azioni

Regulus Therapeutics

Regulus Therapeutics Inc is a biotechnology company focused on the development of microRNA therapies. MicroRNA therapies target diseases such as cancer, metabolic diseases, fibrosis, and inflammatory diseases. The product candidate of the company is RGLS8429, an anti-miR next-generation oligonucleotide targeting miR-17 for the treatment of autosomal dominant polycystic kidney disease (ADPKD), and is in Phase 1b clinical development.

Regulus Therapeutics Inc

REGULUS RES INC by Regulus Resources, Inc.

Regulus Resources Inc

HC Wainwright &amp; Co. analyst Raghuram Selvaraju reiterates Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Buy and maintains $10 price target.

News

Price Target

Reiteration

Analyst Ratings

RGLS

HC Wainwright & Co. Reiterates Buy on Regulus Therapeutics, Maintains $10 Price Target

Biotech

General

Regulus Therapeutics Completes Enrollment Of Fourth Cohort In Phase 1b Multiple-Ascending Dose Clinical Trial Of RGLS8429 For Treatment Of Autosomal Dominant Polycystic Kidney Disease With 26 Patients Enrolled

Oppenheimer analyst Andreas Argyrides reiterates Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Outperform and maintains $7 price target.

Oppenheimer Reiterates Outperform on Regulus Therapeutics, Maintains $7 Price Target

Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) reported quarterly losses of $(0.17) per share which missed the analyst consensus estimate of $(0.13) by 30.77 percent. This is a 54.05 percent increase over losses of $(0.37) per share from the same period last year.

Earnings

Earnings Misses

Regulus Therapeutics Q2 EPS $(0.17) Misses $(0.13) Estimate

Canaccord Genuity analyst Whitney Ijem maintains Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Buy and raises the price target from $11 to $28.

Canaccord Genuity Maintains Buy on Regulus Therapeutics, Raises Price Target to $28

Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades and downgrades, please see our <a href="https://www.benzinga.com/analyst-ratings/">analyst ratings page</a>.
<ul>
<li>JP Morgan cut the price target for Sea Limited (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SE#NYSE">SE</a>) from $84 to $78. JP Morgan analyst Ranjan Sharma downgraded the stock from Overweight to Neutral. Sea shares gained 0.6% to close at $75.89 on Monday. <a href="https://www.benzinga.com/quote/SE/analyst-ratings">See how other analysts view this stock.</a></li>
<li>Morgan Stanley raised the price target for Birkenstock Holding plc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BIRK#NYSE">BIRK</a>) from $44 to $58. Morgan Stanley analyst Edouard Aubin maintained an Equal-Weight rating. Birkenstock shares fell 2.8% to close at $59.78 on Monday. <a href="https://www.benzinga.com/quote/BIRK/analyst-ratings">See how other analysts view this stock.</a></li>
<li>TD Cowen boosted Credo Technology Group Holding Ltd (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CRDO#NASDAQ">CRDO</a>) price target from $24 to $35. TD Cowen analyst Matt Ramsay upgraded the stock from Hold to Buy. Credo Technology shares fell 0.7% to close at $27.29 on Monday. <a href="https://www.benzinga.com/quote/CRDO/analyst-ratings">See how other analysts view this stock.</a></li>
<li>UBS boosted the price target for Cloudflare, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NET#NYSE">NET</a>) from $76 to $82. UBS analyst Roger Boyd upgraded the stock from Sell to Neutral. Cloudflare shares rose 0.9% to close at $78.60 on Monday. <a href="https://www.benzinga.com/quote/NET/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>Needham cut G1 Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GTHX#NASDAQ">GTHX</a>) price target from $12 to $6. Needham analyst Gil Blum maintained a Buy rating. G1 Therapeutics shares fell 10.5% to close at $2.22 on Monday. <a href="https://www.benzinga.com/quotTHXe/G/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>Wells Fargo lowered Capri Holdings Limited (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CPRI#NYSE">CPRI</a>) price target from $57 to $43. Wells Fargo analyst Ike Boruchow upgraded the stock from Equal-Weight to Overweight. Capri shares gained 0.7% to close at $31.51 on Monday. <a href="https://www.benzinga.com/quote/CPRI/analyst-ratings">See how other analysts view this stock.</a></li>
<li>Evercore ISI Group raised the price target for C.H. Robinson Worldwide, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CHRW#NASDAQ">CHRW</a>) from $82 to $99. Evercore ISI Group analyst Jonathan Chappell upgraded the stock from In-Line to Outperform. C.H. Robinson shares gained 2% to close at $88.49 on Monday. <a href="https://www.benzinga.com/quote/CHRW/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>Wells Fargo cut Etsy, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ETSY#NASDAQ">ETSY</a>) price target from $58 to $56. Wells Fargo analyst Ken Gawrelski maintained an Underweight rating. Etsy shares fell 0.4% to close at $59.95 on Monday. <a href="https://www.benzinga.com/quote/ETSY/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>HC Wainwright &amp; Co. raised Regulus Therapeutics Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) price target from $9 to $10. HC Wainwright &amp; Co. analyst Raghuram Selvaraju maintained a Buy rating. Regulus Therapeutics shares fell 18.3% to close at $2.05 on Monday. <a href="https://www.benzinga.com/quote/RGLS/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>Truist Securities boosted Ball Corporation (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BALL#NYSE">BALL</a>) price target from $67 to $76. Truist Securities analyst Michael Roxland upgraded the stock from Hold to Buy. Ball shares rose 1.5% to close at $61.58 on Monday. <a href="https://www.benzinga.com/quote/BALL/analyst-ratings">See how other analysts view this stock.</a></li>
</ul>
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Ball To Rally More Than 23%? Here Are 10 Top Analyst Forecasts For Tuesday

HC Wainwright &amp; Co. analyst Raghuram Selvaraju maintains Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Buy and raises the price target from $9 to $10.

HC Wainwright & Co. Maintains Buy on Regulus Therapeutics, Raises Price Target to $10

Regulus Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) shares were initially trading higher Monday before pulling back and turning negative after the company announced topline results from its study related to the treatment of autosomal dominant polycystic <a href="https://www.benzinga.com/quote/RGLS/analyst-ratings">kidney disease (AKPD)</a>.
What Happened: The results from the Phase 1B MAD clinical trial of RGLS8429 which Regulus announced Monday before the market opened, demonstrating a decrease in htTKV and an increase in PC1 and PC2. PC1 and PC2 are proteins known to inversely correlate with disease severity.
&#8220;We are pleased to see the consistent mechanistic response and reduction in htTKV at the 3mg/kg dose level of RGLS8429,&#8221; said president and head of research and development Preston Klassen, M.D.
Additionally, the treatment was well tolerated across participants.
Related Link: <a href="https://www.benzinga.com/markets/asia/24/06/39456640/yidu-finds-good-medicine-in-regulatory-nod-for-its-ai">Yidu Finds Good Medicine In Regulatory Nod For Its AI</a>
RGLS Price Action: Regulus Therapeutics shares are down 20.3% at $2.00 at the time of writing per <a href="https://www.benzinga.com/pro/">Benzinga Pro</a>.
Image: 428338 from Pixabay.

Movers

What's Going On With Regulus Therapeutics Stock Monday?

WIIM

Regulus Therapeutics shares are trading lower after the company announced results in the Phase 1b Study for ADPKD treatment. The stock initially traded higher, but it has since reversed.

ALNY: 14% &#x7C;&nbsp;<a href="https://www.benzinga.com//node/39453602">Alnylam Pharmaceuticals shares are trading higher after the company announced topline results from its HELIOS-B Phase 3 study of vutrisiran and that it met the primary endpoints and demonstrated statistically significant improvements across all secondary endpoints.</a>
ALT: 20% &#x7C;&nbsp;<a href="https://www.benzinga.com//node/39453064">Altimmune shares are trading higher after the company announced that it presented data from the 48-week Phase 2 MOMENTUM clinical trial of pemvidutide at the American Diabetes Association&#39;s 84th Scientific Sessions.</a>
RGLS: 41% &#x7C;&nbsp;<a href="https://www.benzinga.com//node/39453355">Regulus Therapeutics shares are trading higher after the company announced topline results from the third cohort of patients in its Phase 1b MAD study of RGLS8429 for the treatment of ADPKD.</a>

ALNY

Market-Moving News for June 24th

Regulus Therapeutics Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>), a biopharmaceutical company focused on the discovery and development of innovative medicines targeting microRNAs (the &quot;Company&quot; or &quot;Regulus&quot;), today announced positive topline results from the third cohort of patients in its Phase&nbsp;1b&nbsp;MAD study of RGLS8429 for the treatment of ADPKD.
<a href="https://mma.prnewswire.com/media/370141/regulus_logo_finalnew_Logo.html" target="_blank"><img alt="Regulus Therapeutics Inc. Logo" src="https://mma.prnewswire.com/media/370141/regulus_logo_finalnew_Logo.jpg" /></a>
The Phase&nbsp;1b&nbsp;MAD study is a double-blind, placebo-controlled trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics (PK/PD) of RGLS8429 in adult patients with ADPKD. The study is evaluating RGLS8429 treatment across three different weight-based dose levels and one fixed dose level, including measuring changes in urinary polycystins 1 and 2 (PC1 and PC2), htTKV, cyst architecture, and overall kidney function. PC1 and PC2 are the protein products of the PKD1 and PKD2 genes and have been shown to inversely correlate with disease severity. Enrollment in the fourth cohort, which will include up to 30 patients, has been initiated and patients will receive an open label fixed dose of 300 mg of RGLS8429 every other week for three months. In addition to PC1 and PC2 and safety, imaging biomarkers will also be evaluated.
In the third cohort, 16 subjects were randomized 3:1 to receive either 3 mg/kg of RGLS8429 or placebo every other week for three months.
<ul>
<li>RGLS8429 was well tolerated with no safety concerns</li>
<li>Continued evidence of a mechanistic dose response was observed following completion of 3 mg/kg dose level based on urinary PC1 and PC2</li>
<li>3 mg/kg demonstrated more consistent increases in PC1 and PC2 across patients compared to earlier cohorts</li>
<li>Percent change from baseline in PC1 and PC2 demonstrated a dose response across all doses tested, with statistical significance seen at 3 mg/kg compared to placebo</li>
<li>Exploratory MRI imaging analysis suggested RGLS8429 reduced htTKV at 3 mg/kg after 3 months of dosing</li>
<li>70%&nbsp;of subjects demonstrated reductions in htTKV following completion of 3 mg/kg dose level</li>
</ul>
&quot;We are pleased to see the consistent mechanistic response and reduction in htTKV at the 3mg/kg dose level of RGLS8429 along with an appropriate safety and tolerability profile,&quot; said&nbsp;Preston Klassen, M.D., President and Head of Research &amp; Development. &nbsp;&quot;These data support our ongoing and final 300 mg fixed dose cohort in this Phase&nbsp;1b&nbsp;trial. We believe the data from this study will form the basis for a potentially pivotal Phase 2/3 study of RGLS8429 under an Accelerated Approval regulatory pathway to be discussed with the FDA.&quot;
&quot;Building on the positive results from our first two cohorts, these cohort 3 data, particularly the reduction in htTKV seen in the majority of patients, further strengthen our conviction in RGLS8429&#39;s ability to potentially address the underlying, genetic cause of ADPKD,&quot; said&nbsp;Jay Hagan, CEO of Regulus Therapeutics. &quot;We anticipate requesting an End-of-Phase 1 meeting with the FDA in the&nbsp;fourth quarter&nbsp;of this year and look forward to providing a data update from the open-label fourth and final cohort of the Phase&nbsp;1b&nbsp;MAD study by year-end.&quot;

Regulus Therapeutics Announces Results in Phase 1b Study for ADPKD Treatment

Regulus Therapeutics Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>), a biopharmaceutical company focused on the discovery and development of innovative medicines targeting microRNAs (the "Company" or "Regulus"), today announced that it expects to be added to the broad-market Russell 3000&#xAE; Index and the Russell 2000&#xAE; Index at the conclusion of the 2024 Russell US Indexes annual reconstitution, effective at the open of US equity markets on Monday, July 1st, according to a preliminary list of additions posted Friday, May 24th.

Regulus Therapeutics Announces Expected Addition To The Russell 3000 And Russell 2000 Indexes

Jones Trading analyst Catherine Novack initiates coverage on Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Buy rating and announces Price Target of $8.

Initiation

Jones Trading Initiates Coverage On Regulus Therapeutics with Buy Rating, Announces Price Target of $8

Health Care

Contracts

TECH

Bio-Techne And Regulus Therapeutics Announced Continued Technical And Clinical Collaboration Following Regulus' Topline Results From The Second Cohort Of Phase 1B Multiple Ascending Study Of RGLS8429 For Autosomal Dominant Polycystic Kidney Disease

HC Wainwright &amp; Co. analyst Raghuram Selvaraju reiterates Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Buy and maintains $9 price target.

HC Wainwright & Co. Reiterates Buy on Regulus Therapeutics, Maintains $9 Price Target

Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) reported quarterly losses of $(0.29) per share which missed the analyst consensus estimate of $(0.22) by 31.82 percent.

Regulus Therapeutics Q1 2024 GAAP EPS $(0.29) Misses $(0.22) Estimate

<h3>Gainers</h3>
<ul>
<li>Agape ATP (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATPC#NASDAQ">ATPC</a>) shares rose 23.0% to $0.32 during Monday's after-market session. The market value of their outstanding shares is at $24.9 million. </li>
<li>FibroGen (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/FGEN#NASDAQ">FGEN</a>) shares increased by 20.68% to $1.4. The market value of their outstanding shares is at $139.2 million. As per the news, the Q1 earnings report came out today. </li>
<li>RxSight (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RXST#NASDAQ">RXST</a>) shares rose 11.39% to $70.0. The company's market cap stands at $2.6 billion. As per the news, the Q1 earnings report came out today. </li>
<li>Innovative Eyewear (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LUCY#NASDAQ">LUCY</a>) shares increased by 10.81% to $0.25. The market value of their outstanding shares is at $3.2 million. </li>
<li>Hims &amp; Hers Health (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HIMS#NYSE">HIMS</a>) shares increased by 10.72% to $12.9. The company's market cap stands at $2.7 billion. As per the press release, Q1 earnings came out today. </li>
<li>iSpecimen (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ISPC#NASDAQ">ISPC</a>) stock increased by 8.58% to $0.3. The company's market cap stands at $2.7 million. </li>
</ul>
<h3>Losers</h3>
<ul>
<li>Predictive Oncology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/POAI#NASDAQ">POAI</a>) shares decreased by 9.1% to $1.6 during Monday's after-market session. The market value of their outstanding shares is at $6.5 million. </li>
<li>SI-BONE (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SIBN#NASDAQ">SIBN</a>) shares fell 6.77% to $13.5. The company's market cap stands at $556.2 million. As per the news, the Q1 earnings report came out today. </li>
<li>Anitra (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/AZTR#AMEX">AZTR</a>) stock fell 5.68% to $0.25. The company's market cap stands at $7.2 million. </li>
<li>Ontrak (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OTRK#NASDAQ">OTRK</a>) stock declined by 5.28% to $0.24. The market value of their outstanding shares is at $11.2 million. </li>
<li>Clene (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CLNN#NASDAQ">CLNN</a>) shares declined by 5.15% to $0.4. The company's market cap stands at $51.6 million. </li>
<li>Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) shares fell 4.96% to $2.3. The market value of their outstanding shares is at $150.5 million. 
See Also: <a href="http://www.benzinga.com/money/best-healthcare-stocks/" title="www.benzinga.com/money/best-healthcare-stocks/">www.benzinga.com/money/best-healthcare-stocks/</a></li>
</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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12 Health Care Stocks Moving In Monday's After-Market Session

Regulus Therapeutics GAAP EPS of -$0.17 misses by $0.02

H.C. Wainwright analyst Ram Selvaraju reiterated a Buy rating on Regulus (RGLS – Research Report) today and set a price target of $10.00. Ram Selva...

Buy Rating Reaffirmed for Regulus Therapeutics Amidst Promising Clinical Data and Progress Towards Pivotal Trial

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RGLS Stock Earnings: Regulus Therapeutics Misses EPS for Q2 2024

Companies in the Healthcare sector have received a lot of coverage today as analysts weigh in on Novavax (NVAX – Research Report), Regulus (RGLS – ...

Analysts Offer Insights on Healthcare Companies: Novavax (NVAX), Regulus (RGLS) and Canopy Growth (CGC)

Canaccord Genuity analyst Whitney Ijem has maintained their bullish stance on RGLS stock, giving a Buy rating on August 9. Whitney Ijem has given h...

Buy Rating Affirmed for Regulus Amidst Minor Clinical Delay and Strong Financial Position

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Analysts Offer Insights on Healthcare Companies: OmniAb (OABI), Avadel Pharmaceuticals (AVDL) and Regulus (RGLS)

In a report released today, Andreas Argyrides from Oppenheimer maintained a Buy rating on Regulus (RGLS – Research Report), with a price target of ...

Regulus (RGLS) Receives a Buy from Oppenheimer

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Analysts' Top Healthcare Picks: Sonnet BioTherapeutics Holdings (SONN), Agilent (A)

Regulus (RGLS – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst today. Analyst Ram Selvaraju from H.C. Wain...

Buy Rating Affirmed for Regulus Therapeutics Amid Positive RGLS8429 Study Milestones and MicroRNA Research Recognition

Canaccord Genuity analyst Whitney Ijem has maintained their bullish stance on RGLS stock, giving a Buy rating yesterday. Whitney Ijem has given his...

Buy Rating Affirmed for Regulus Amid Promising miRNA Therapy Advances for ADPKD

AVDL

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Press Releases

Regulus Therapeutics Advances to Cohort 4 of Phase 1b Multiple-Ascending Dose (MAD) Clinical Trial of RGLS8429 for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Regulus Therapeutics Reports First Quarter 2024 Financial Results and Recent Updates

Regulus Therapeutics Announces Promotion of Rekha Garg, M.D., M.S., to Chief Medical Officer

Regulus Therapeutics Announces Expected Addition to the Russell 3000® and Russell 2000® Indexes

Regulus Therapeutics Announces Positive Topline Data from the Third Cohort of Patients in its Phase 1b Multiple-Ascending Dose (MAD) Clinical Trial of RGLS8429 for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Regulus Therapeutics Announces Participation at Two Healthcare Investment Conferences

Regulus Therapeutics to Present at the Canaccord Genuity 44th Annual Growth Conference

Regulus Therapeutics Reports Second Quarter 2024 Financial Results and Recent Updates

Regulus Therapeutics Announces Completion of Enrollment in Fourth Cohort of Phase 1b Multiple-Ascending Dose (MAD) Clinical Trial of RGLS8429 for the Treatment of Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

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