Silence Therapeutics Azioni (NASDAQ: SLN)

Ultime notizie per Silence Therapeutics (NASDAQ:SLN) Azioni

Silence Therapeutics

Silence Therapeutics PLC is a biotechnology company focused on discovering and developing novel molecules incorporating short-interfering ribonucleic acid. its pipeline products are; SLN360 therapy designed to temporarily block a specific gene's message that would otherwise trigger an unwanted effect. By silencing the LPA gene, the levels of Lp(a) are lowered, which in turn is expected to lower the risks of heart diseases, heart attacks, and strokes, and SLN124 therapy aims to temporarily silence TMPRSS6, a gene that prevents the liver from producing a particular hormone that controls iron levels in the body hepcidin. As hepcidin increases, iron levels in the blood are expected to decrease, which may increase the production of healthy red blood cells, thereby reducing anemia.

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As part of the previously announced Board refreshment plan, Lydia Thomas and Shirley Franklin will retire from the Board at the Annual Meeting.
Following the Annual Meeting, the Board will comprise nine directors, eight of whom are independent and eight of whom will have been elected in the last six years.

Management

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Following the merger of CenterGroup with and into First Commonwealth, CenterBank will merge with and into First Commonwealth Bank.
The business combination will increase First Commonwealth's presence in the Cincinnati market, adding approximately $348.4 million of total assets, 3 branch locations, a loan production office and a mortgage office to First Commonwealth's Cincinnati franchise.&nbsp;

CenterGroup To Merge With And Into First Commonwealth In An All-stock Transaction Valued At $54.6M In Aggregate

"With the first quarter results roughly as anticipated, we are maintaining our full-year fiscal 2025 guidance, including total revenue and adjusted EBITDA growth of 5% at the midpoint of our guidance," the company said.
The company expects adjusted EBITDA in the range of $150 million to $160 million, and free cash flow between $85 million to $95 million.&nbsp; &nbsp;

Guidance

EPAC

Enerpac Tool Maintains FY25 Net Sales Outlook Of $610M - $625M (Est $622M), Organic Sales Growth Of Approximately 0% - 2%

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Leading technology company NVIDIA Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) is one of many companies that could be impacted by the future White House administration <a href="https://www.benzinga.com/news/24/11/41768178/donald-trump-defeats-kamala-harris-to-win-2024-election">under President-elect</a> Donald Trump.
Here's a look back at Nvidia's performance during Trump's last term and the potential gains investors could have realized.
What Happened: Nvidia was<a href="https://www.benzinga.com/markets/24/10/41595302/these-10-stocks-were-the-best-s-p-500-performers-in-2017-when-trump-was-president-will-history-repea"> one of the best performing </a>S&amp;P 500 stocks in 2017, the first year Trump served as president of the United States.
The stock ranked ninth for the year with a +81% return in 2017. From the date of Trump's inauguration on Jan. 20, 2017 to President Joe Biden's inauguration on Jan. 20, 2021, Nvidia shares gained more than 400%.
Nvidia was<a href="https://www.benzinga.com/general/education/24/10/41665149/these-10-stocks-were-s-p-500s-top-performers-in-bidens-first-year-could-the-trend-continue-if-h"> also a top performing </a>S&amp;P 500 sock in 2021, the first year of Biden&#8217;s term in office. The stock ranked ninth once again, gaining 125.5% in 2021.
The semiconductor company has been one of the top performers in recent years, joining the $1 trillion market capitalization club <a href="https://www.benzinga.com/news/23/05/32630114/nvidia-becomes-ninth-company-to-hit-1-trillion-market-cap-who-could-be-next-to-join-elusive-club">in May 2023 </a>and around a year later becoming the most valuable company in the world.
Nvidia <a href="https://www.benzinga.com/news/large-cap/24/11/41761849/nvidia-blows-past-apple-to-become-worlds-most-valuable-company">passed the milestone </a>of world's most valuable company several times in 2024 and is currently the third most valuable company in the world with a market capitalization of $3.16 trillion, trailing only Apple ($3.76 trillion) and Microsoft ($3.27 trillion).
While the impact of Trump on semiconductors, Taiwan, and the broader tech sector—and by extension, Nvidia&#8217;s share price—remains uncertain, history shows Nvidia tends to outperform in the first year of a new presidential term.
Are you buying when the CEOs of the Magnificent 7 are selling?
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<li>Stay in the know with our Insider Trades page — <a href="https://www.benzinga.com/sec/insider-trades/">see when leaders like Mark Zuckerberg, Elon Musk, and Jensen Huang are offloading their own shares.</a></li>
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Investing $1,000 in NVDA: Investors who bought and held onto Nvidia shares when Trump was inaugurated as president of the United States would likely be happy with their return.
Nvidia stock traded at a split-adjusted high of $2.67 on Jan. 20, 2017. A $1,000 investment could have purchased 374.53 NVDA shares at the time.
Today, that investment would be worth $48,309.58 based on a $128.97 price for Nvidia at the time of writing. The investment would be up 4,731.0% over the last nearly eight years.
For comparison, the same $1,000 invested in the SPDR S&amp;P 500 ETF Trust (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SPY#NYSE">SPY</a>), which tracks the S&amp;P 500, would have delivered significantly lower returns.
The $1,000 investment could have bought 4.40 SPY shares, which would be worth $2,594.06 today based on a price of $589.56 for SPY at the time of writing. This investment would be up 159.4% over the same time period.
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Photo: Shutterstock

Education

Politics

NVDA

If You Invested $1,000 In NVIDIA Stock When Donald Trump Became President In 2017, Here's How Much You'd Have Now

Lennar Expects Q1 Gross Margin To Be 19.0% - 19.25%; Says Will Not Guide To Full Year Gross Margin At This Time Until Having Better Sense Of Market Conditions

Lennar Expects To Deliver 17,000 - 17,500 Homes For Q1 And 86,000 - 88,000 Homes For 2025, Including Impact Of Rausch Coleman Acquisition

Federal Reserve Chair Jerome Powell adopted a hawkish stance during his Wednesday press conference after the December Fed meeting, sparking a market bloodbath as the New York session <a href="https://www.benzinga.com/economics/macro-economic-events/24/12/42563299/feds-powell-shocks-markets-its-a-new-phase-were-significantly-closer-to-neutral">headed to the close.</a>
Although the Federal Reserve lowered interest rates by 0.25% to a range of 4.25%-4.5%, as widely anticipated, the updated economic projections suggest just two potential rate cuts in 2025 — down from four projected in September and fewer than the three anticipated by markets before the meeting.
Powell described the shift as &#8220;a new phase&#8221; for monetary policy, emphasizing that after 100 basis points of rate cuts in 2024, rates are now significantly closer to a neutral stance. 
Stocks tumbled across the board, the U.S. dollar soared to two-year highs and Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) cratered over 5%, as investors digested the reality of a shift in the monetary policy stance by the Federal Reserve.
The CBOE Volatility Index, known as the VIX and Wall Street&#8217;s fear gauge, skyrocketed 58% to 25, reflecting a spike in investor uncertainty and heightened anxiety over the future of interest rates.
<figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="1024" height="557" src="https://editorial-assets.benzinga.com/wp-content/uploads/2024/12/18161803/image-161-1024x557.png" alt="" class="wp-image-698569" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2024/12/18161803/image-161-1024x557.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/12/18161803/image-161-300x163.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/12/18161803/image-161-768x418.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/12/18161803/image-161-1536x836.png 1536w,https://editorial-assets.benzinga.com/wp-content/uploads/2024/12/18161803/image-161.png 1920w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure>
<h3 class="wp-block-heading">Wall Street Wipeout: Major Indices Slammed</h3>
The Dow Jones Industrial Average, as tracked by the SPDR Dow Jones Industrial Average ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DIA#NYSE">DIA</a>), dropped 1,123 points, falling 2.6% to close at 42,326, marking its worst one-day drop since September 2022. Amazon.com Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMZN#NASDAQ">AMZN</a>) recorded the worst performance among blue-chip stocks, down 4.6%.
The S&amp;P 500 index — tracked by the SPDR S&amp;P 500 ETF Trust (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SPY#NYSE">SPY</a>) — fell 178 points, down 2.9% to 5,872, also marking its worst day since September 2022. Paycom Software Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PAYC#NYSE">PAYC</a>) was the major laggard within the S&amp;P 500, down 10%.
The tech-heavy Nasdaq 100, tracked by the Invesco QQQ Trust, Series 1 (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QQQ#NASDAQ">QQQ</a>), experienced an even sharper drop of 3.6%, closing at 21,209 as interest rate-sensitive technology stocks took a beating. Tesla Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>) tumbled 8.1%, marking the worst performance within the Nasdaq 100.
Every Magnificent Seven company ended the day in the red, collectively erasing more than $600 billion in market value on Wednesday.
Small caps in the Russell 2000 posted the steepest losses, plummeting 4.7% to 2,225. With Wednesday&#8217;s move, the iShares Russell 2000 ETF (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IWM#NASDAQ">IWM</a>) has fully erased the post-election rally.
All major U.S. equity sectors finished in the red. 
Consumer Discretionary stocks suffered the most, plunging 4.5%, followed by Real Estate, which dropped 4% as rising rates weigh heavily on growth-oriented and interest-rate-sensitive industries.
Technology, the largest sector by market capitalization, fell 3.2%, with chipmakers and software companies bearing the brunt of the selloff. 
Communications and Materials both declined 2.9%, while Financials dropped 3%, reflecting pressure across cyclical areas of the market.
Even traditionally defensive sectors failed to escape the selloff. Utilities and Consumer Staples fell 2.4% and 1.5%, respectively.
<h3 class="wp-block-heading">Dollar Surges To 2-Year Highs, Hammers Gold And Bitcoin</h3>
The U.S. dollar emerged as the day's clear winner, with the dollar index (DXY), followed by the Invesco DB USD Index Bullish Fund ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UUP#NYSE">UUP</a>), climbing 1.2% to reach its highest level since November 2022.
As the greenback rallied, gold failed to provide a safe haven, falling 2.1% to $2,580 per ounce, while silver dropped 3.5%.
Risk-off sentiment extended into alternative assets. Bitcoin plunged 5.5%, trading just above $101,500.
During the press conference, Powell was asked whether the U.S. government should consider building a strategic reserve of Bitcoin. Powell quickly dismissed the idea, making it clear that such a move is not on the Fed&#8217;s radar.
"We're not allowed to own Bitcoin," Powell said, emphasizing the legal and structural limitations of the Federal Reserve. "The Federal Reserve Act dictates what we can own, and we're not seeking any changes to that law."
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The proposed decision is scheduled to be voted on by the CPUC on January 16, 2025. When a final decision is issued by the CPUC, the new rates will be effective and retroactive to January 1, 2023.&nbsp;
As a result, the impact from retroactive rates for the full year of 2023 and from the second-year rate increases through the nine months ended September 30, 2024 are expected at this time to be reflected in the 2024 fourth quarter results.

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The Q1 earnings report for Enerpac Tool Group (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EPAC#NYSE">EPAC</a>) was released on Wednesday, December 18, 2024 at 04:30 PM.
Here's what investors need to know about the latest announcement.
<h3>Earnings</h3>
Enerpac Tool Group missed estimated earnings by -2.0%, reporting an EPS of $0.4 versus an estimate of $0.41.
Revenue was up $3.23 million from the same period last year.
<h3>Analysis of Past Earnings</h3>
Last quarter the company missed on EPS by $0.03 which was followed by a 1.0% drop in the share price the next day.
Here's a look at Enerpac Tool Group's past performance:

<table>
<thead>
<tr>
<th>Quarter</th>
<th>Q4 2024</th>
<th>Q3 2024</th>
<th>Q2 2024</th>
<th>Q1 2024</th>
</tr>
</thead>
<tbody>
<tr>
<td>EPS Estimate</td>
<td>0.53</td>
<td>0.47</td>
<td>0.36</td>
<td>0.32</td>
</tr>
<tr>
<td>EPS Actual</td>
<td>0.50</td>
<td>0.47</td>
<td>0.36</td>
<td>0.39</td>
</tr>
<tr>
<td>Revenue Estimate</td>
<td>156.70M</td>
<td>153.20M</td>
<td>141.10M</td>
<td>137.90M</td>
</tr>
<tr>
<td>Revenue Actual</td>
<td>158.71M</td>
<td>150.39M</td>
<td>138.44M</td>
<td>141.97M</td>
</tr>
</tbody>
</table>

To track all earnings releases for Enerpac Tool Group <a href="https://www.benzinga.com/quote/EPAC/earnings">visit their earnings calendar here.</a> 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Earnings

Recap: Enerpac Tool Group Q1 Earnings

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Buybacks

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Enerpac Tool Group (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EPAC#NYSE">EPAC</a>) reported quarterly earnings of $0.40 per share which missed the analyst consensus estimate of $0.41 by 2.44 percent. This is a 2.56 percent increase over earnings of $0.39 per share from the same period last year. The company reported quarterly sales of $145.20 million which beat the analyst consensus estimate of $144.40 million by 0.55 percent. This is a 2.27 percent increase over sales of $141.97 million the same period last year.

Earnings Beats

Earnings Misses

Enerpac Tool Group Q1 2025 Adj EPS $0.40 Misses $0.41 Estimate, Sales $145.20M Beat $144.40M Estimate

Lennar (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LEN#NYSE">LEN</a>) reported quarterly earnings of $4.03 per share which missed the analyst consensus estimate of $4.16 by 3.12 percent. This is a 22.05 percent decrease over earnings of $5.17 per share from the same period last year. The company reported quarterly sales of $9.95 billion which missed the analyst consensus estimate of $10.08 billion by 1.35 percent. This is a 9.32 percent decrease over sales of $10.97 billion the same period last year.

Lennar Q4 2024 Adj EPS $4.03 Misses $4.16 Estimate, Sales $9.95B Miss $10.08B Estimate

Aon (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/AON#NYSE">AON</a>) has outperformed the market over the past 15 years by 4.16% on an annualized basis producing an average annual return of 15.8%. Currently, Aon has a market capitalization of $76.25 billion. 
Buying $1000 In AON: If an investor had bought $1000 of AON stock 15 years ago, it would be worth $9,117.66 today based on a price of $352.58 for AON at the time of writing.
<h3>Aon's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1734557412_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much You Would Have Made Owning Aon Stock In The Last 15 Years

The Federal Reserve announced a widely anticipated 25-basis-point interest rate cut at its December meeting Wednesday, lowering the federal funds rate to a <a href="https://www.benzinga.com/news/econ-s/24/12/42561549/fed-slashes-interest-rates-by-0-25-as-predicted-december-dot-plot-flags-only-2-potential-cuts-in-2025">range of 4.25% to 4.5%.</a>
The cut is the third consecutive reduction in borrowing costs following a 50-basis-point cut in September and a 25-basis-point move in November and brings rates to the lowest level since January 2023. 
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Tthe Fed now projects two additional 0.25% rate cuts in 2025, a meaningful revision from the full percentage point of cuts expected in September. Markets reacted sharply lower following the Fed's decision with the SPDR S&amp;P 500 (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SPY#NYSE">SPY</a>) ending the session 2.98% lower at $586.28 and the Invesco QQQ Trust (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QQQ#NASDAQ">QQQ</a>) closing 3.61% lower at $516.47.
Expert Ideas: Chris Zaccarelli, chief investment officer for Northlight Asset Management, said that markets are forward-looking and reacted to the Fed's 2025 projection and not the quarter-point cut that it also delivered. 
"Santa came early and dropped a 25-bps rate cut in the market's stocking but accompanied it with a note saying that there would be coal next year," Zaccarelli said.&nbsp;
Bill Adams, chief economist for Comerica Bank, said the Fed is reacting to the incoming Trump administration's policies, which it sees as most likely to boost growth and inflation, as well as tighten the job market. 
Trump does not have much control over the pace of rate cuts in the near term, Adams said, but "that could change in 2026 if President-elect Trump gets the Senate to confirm a new Fed chair who is more sympathetic to his policy goals."
Charlie Ripley, senior investment strategist for Allianz Investment Management, highlighted the growing concerns around inflation and the Fed's dot-plot, which shows shallower rate cuts ahead in both 2025 and 2026. 
"The main takeaway from today's Fed meeting was that inflation risks are back, and the Fed is clearly concerned," Ripley said.&nbsp;
"The Fed has been able to maneuver 100 basis points of cuts so far in this cycle but given the trajectory of the economy and the recent uptick of inflation, it is going to be more difficult for the Fed to provide basis to continue cutting rates at the same pace," he added.&nbsp;
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Photo via Shutterstock.

Analyst Color

Macro Economic Events

'Santa Came Early' But Fed Brings 'Coal Next Year': Experts Weigh In On Interest Rate Cut, 2025 Projections

The company is in advanced discussions with various capital sources, and it works to finalize securing the capital necessary to move forward with its operations.
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GOEV

Canoo  Furloughs 82 Employees, Both Salaried And Hourly, And Idling Its Factories In Oklahoma

Micron Technology Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MU#NASDAQ">MU</a>) reported financial results for the first quarter of fiscal 2025 after the market close on Wednesday. Here&#8217;s a rundown <a href="https://www.benzinga.com/pressreleases/24/12/g42563530/micron-technology-inc-reports-results-for-the-first-quarter-of-fiscal-2025">of the report</a>.
Q1 Earnings: Micron reported first-quarter revenue of $8.71 billion, missing the&nbsp;<a href="https://www.benzinga.com/calendars/earnings" target="_blank" rel="noreferrer noopener">consensus estimate</a>&nbsp;of $8.72 billion. The company reported first-quarter adjusted earnings of $1.79 per share, beating analyst estimates of $1.76 per share, according to&nbsp;<a href="http://pro.benzinga.com/" target="_blank" rel="noreferrer noopener">Benzinga Pro</a>.
Operating cash flow came in at $3.24 billion versus $3.41 billion in the prior quarter and $1.4 billion in the comparable quarter last year. Adjusted free cash flow was $112 million in the quarter, down from $323 million in the prior quarter. The company ended the quarter with $8.75 billion in cash, marketable investments and restricted cash.
&#8220;Micron delivered a record quarter, and our data center revenue surpassed&nbsp;50%&nbsp;of our total revenue for the first time,&#8221; said&nbsp;Sanjay Mehrotra, president and CEO of Micron.
&#8220;While consumer-oriented markets are weaker in the near term, we anticipate a return to growth in the second half of our fiscal year. We continue to gain share in the highest margin and strategically important parts of the market and are exceptionally well positioned to leverage AI-driven growth to create substantial value for all stakeholders.&#8221;
Check This Out: <a href="https://www.benzinga.com/trading-ideas/24/12/42561975/whos-next-to-join-tesla-broadcom-in-1-trillion-club-over-50-say-the-worlds-biggest-retailer">Who&#8217;s Next To Join Tesla, Broadcom In $1 Trillion Club? Over 50% Say The World&#8217;s Biggest Retailer</a>
Outlook:&nbsp;Micron sees second-quarter revenue of $7.9 billion, plus or minus $200 million, versus estimates of $9 billion. The company expects second-quarter adjusted earnings of $1.43 per share, plus or minus 10 cents per share, versus estimates of $1.92 per share. 
Micron&#8217;s soft guidance appears to be weighing on shares after hours. Management will further discuss the quarter on a call with analysts and investors at 4:30 p.m. ET. 
MU Price Action: <a href="https://www.benzinga.com/quote/MU" target="_blank" rel="noreferrer noopener">Micron shares</a> were down 13.16% in after-hours, trading at $90.50 at the time of publication Wednesday, according to <a href="http://pro.benzinga.com/" target="_blank" rel="noreferrer noopener">Benzinga Pro</a>.
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Photo: Courtesy of Micron.

After-Hours Center

Tech

Micron Q1 Earnings: Revenue Miss, EPS Beat, Soft Guidance Sinks Shares As Consumer Markets Turn 'Weaker' In Near Term

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Silence Therapeutics (SLN – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst today. Analyst Kostas Biliouris...

Silence Therapeutics: Anticipated Zerlasiran Partnership and Favorable Pelacarsen CVOT Outlook Drive Buy Rating

Silence Therapeutics (SLN) has released an update. Silence Therapeutics has unveiled promising Phase 1 data for their siRNA therapy, divesiran, sho...

Silence Therapeutics Advances Promising siRNA Therapy for PV

Silence Therapeutics (SLN) announced additional results from the Phase 1 open label portion of the SANRECO study of divesiran, a siRNA targeting TM...

Silence Therapeutics announces additional results from SANRECO study

Analyst Michael Ulz of Morgan Stanley maintained a Buy rating on Silence Therapeutics (SLN – Research Report), retaining the price target of $49.00...

Promising Prospects for Silence Therapeutics: Buy Rating Justified by Positive Phase 1 Data and Safety Profile

There's a lot to be optimistic about in the Healthcare sector as 2 analysts just weighed in on Stoke Therapeutics (STOK – Research Report) and Sile...

Analysts Offer Insights on Healthcare Companies: Stoke Therapeutics (STOK) and Silence Therapeutics (SLN)

There's a lot to be optimistic about in the Healthcare sector as 3 analysts just weighed in on Crispr Therapeutics AG (CRSP – Research Report), Sil...

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