La vendita allo scoperto per SpringWorks Therapeutics dà agli investitori un'idea del grado in cui gli investitori stanno scommettendo sul declino delle azioni di SpringWorks Therapeutics. I dati relativi alle vendite allo scoperto vengono aggiornati ogni due settimane.

SpringWorks Therapeutics (NASDAQ:SWTX) Azioni, Report sulle vendite allo scoperto

SpringWorks Therapeutics

SpringWorks Therapeutics Inc is a clinical stage biopharmaceutical company applying a precision medicine approach to acquiring, developing and commercializing life-changing medicines for underserved patient populations suffering from devastating rare diseases and cancer. The company has a differentiated portfolio of small molecule targeted oncology product candidates and is advancing two potentially registrational clinical trials in rare tumor types, as well as several other programs addressing highly prevalent, genetically defined cancers.

SpringWorks Therapeutics, Inc. - common stock

SpringWorks Therapeutics Inc

<a href="https://www.whitehouse.gov/briefing-room/statements-releases/2024/11/01/statement-from-president-joe-biden-on-the-october-2024-jobs-report/" title="https://www.whitehouse.gov/briefing-room/statements-releases/2024/11/01/statement-from-president-joe-biden-on-the-october-2024-jobs-report/">https://www.whitehouse.gov/briefing-room/statements-releases/2024/11/01/statement-from-president-joe-biden-on-the-october-2024-jobs-report/</a>

Macro Notification

News

General

Biden, Responding To October Jobs Data, Says Job Growth Is Expected To Rebound In November; Adds ' There's More Work To Do'; Says Hurricanes, Strike Activity Lowered Job Growth

On Thursday, ESSA Pharma Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EPIX#NASDAQ">EPIX</a>) announced its plans to terminate the Phase 2 trial of masofaniten combined with enzalutamide versus enzalutamide single agent in patients with metastatic castration-resistant prostate cancer (mCRPC) naïve to <a target="_blank" href="https://www.benzinga.com/pressreleases/24/10/n41669391/essa-pharma-announces-termination-of-phase-2-study-evaluating-masofaniten-combined-with-enzalutami" rel="noreferrer noopener">second-generation antiandrogens</a>.
This decision was based on a protocol-specified interim review of the safety, PK, and efficacy data, which showed a much higher rate of PSA90 response in patients treated with Pfizer Inc&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) Xtandi (enzalutamide) monotherapy (which is the standard of care for this patient population) than expected based on historical data.
In addition, there was no clear efficacy benefit seen with the combination of masofaniten plus enzalutamide compared to enzalutamide single agent.
A futility analysis determined a low likelihood of meeting the prespecified primary endpoint of the study.
The combination of masofaniten plus enzalutamide was well-tolerated with no new safety signals and a safety profile similar to that seen in Phase 1 studies.
&#8220;We made the difficult decision to terminate this Phase 2 study following the interim analysis because we concluded that the emerging efficacy profile of masofaniten combined with enzalutamide would not likely meet the primary endpoint of the study, nor our internal requirements for a prostate cancer therapy candidate,&#8221; said&nbsp;David Parkinson, President, and CEO.
As part of the effort to focus its resources, ESSA is also planning to terminate the other remaining company-sponsored and investigator-sponsored clinical studies evaluating masofaniten either as a monotherapy or in combination <a target="_blank" href="https://www.benzinga.com/pressreleases/24/09/n40862721/essa-pharma-presents-updated-phase-12-masofaniten-epi-7386-clinical-data-at-the-2024-esmo-congress" rel="noreferrer noopener">with other agents</a>.
As of&nbsp;September 30, 2024, the company had available cash reserves and short-term investments of&nbsp;$126.8 million&nbsp;and net working capital of&nbsp;$124.3 million.
In September, ESSA Pharma announced the presentation of updated dose escalation data from its Phase 1/2 study of masofaniten (formerly EPI-7386) in combination with enzalutamide at the 2024 European Society for Medical Oncology (ESMO) Congress.
Across all dose cohorts, 88% of patients (14 of 16) achieved PSA50, 88% of patients (14 of 16) achieved PSA90, 69% of patients (11 of 16) achieved PSA90 in less than 90 days, and 63% of patients (10 of 16) achieved PSA &lt;0.2ng/mL.
Price Action: EPIX stock was down 69.80% at $1.57 during the premarket session at the last check on Friday.
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</ul>

Biotech

Health Care

Movers

EPIX

Cancer-Focused ESSA Pharma Ends Prostate Cancer Trial Due to Insufficient Efficacy From Combination Therapy

LyondellBasell Industries N.V. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LYB#NYSE">LYB</a>) shares are trading lower after the company reported worse-than-expected <a target="_blank" href="https://www.benzinga.com/pressreleases/24/11/g41679038/lyondellbasell-reports-third-quarter-2024-earnings" rel="noreferrer noopener">third-quarter results</a>.
LYB reported revenues of $10.332 billion, down 2.8% year over year and missing the consensus of $10.601 billion.
Adjusted EBITDA stood at $1.21 billion (-14.1% Y/Y), and the margin contracted by 154 bps to 11.7%. Adjusted EPS stood at $1.88, <a target="_blank" href="https://www.benzinga.com/earnings" rel="noreferrer noopener">below the consensus of $1.98.</a>
North American polyethylene margins rose due to lower ethane and gas costs, with demand up over 7% year-to-date. High cracker operating rates boosted third-quarter&nbsp;ethylene volumes, while Europe and Asia margins benefited from lower feedstock costs.
LyondellBasell generated $670 million operating cash flow in the third quarter, with 80% cash conversion over 12 months.
The company invested $368 million in capital expenditures, returned $479 million to shareholders, and held $2.6 billion in cash with $7.3 billion in liquidity.
LyondellBasell&#8217;s CEO, Peter Vanacker, announced that the company started construction on its new MoReTec-1 facility in Germany, a key step toward a sustainable future.
Q4 Outlook: LyondellBasell anticipates softer demand in the fourth quarter due to seasonality, with sequentially higher natural gas and ethane feedstock&nbsp;costs likely impacting North American integrated&nbsp;polyolefins margins.
Operating rates are projected at 85% for North American O&amp;P assets, 60% for European O&amp;P, and 75% for I&amp;D assets, with easing interest rates expected to boost durable goods demand in 2025.
&#8220;Despite challenging global macroeconomic conditions, our strong North American operations allowed us to capitalize on favorable ethylene margins in the region,&#8221; said Vanacker.
Price Action: LYB shares traded lower by 0.98% at $86.00 premarket at the last check Friday.

Earnings

Equities

Guidance

LyondellBasell Q3 Results Miss Estimates, Signals Softer Demand And Rising Costs For Q4

Oppenheimer analyst Edward Yang maintains Onto Innovation (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ONTO#NYSE">ONTO</a>) with a Outperform and raises the price target from $260 to $275.

Price Target

Analyst Ratings

ONTO

Oppenheimer Maintains Outperform on Onto Innovation, Raises Price Target to $275

Oppenheimer analyst Jed Kelly maintains LendingTree (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TREE#NASDAQ">TREE</a>) with a Outperform and raises the price target from $65 to $70.

TREE

Oppenheimer Maintains Outperform on LendingTree, Raises Price Target to $70

Keybanc analyst Alex Markgraff maintains Mastercard (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MA#NYSE">MA</a>) with a Overweight and raises the price target from $515 to $580.

Keybanc Maintains Overweight on Mastercard, Raises Price Target to $580

Oppenheimer analyst Leland Gershell maintains argenx (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ARGX#NASDAQ">ARGX</a>) with a Outperform and raises the price target from $560 to $646.

ARGX

Oppenheimer Maintains Outperform on argenx, Raises Price Target to $646

Oppenheimer analyst Michael Phillips maintains Hanover Insurance Gr (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/THG#NYSE">THG</a>) with a Outperform and raises the price target from $165 to $177.

Oppenheimer Maintains Outperform on Hanover Insurance Gr, Raises Price Target to $177

JP Morgan analyst Doug Anmuth maintains eBay (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EBAY#NASDAQ">EBAY</a>) with a Neutral and lowers the price target from $60 to $58.

EBAY

JP Morgan Maintains Neutral on eBay, Lowers Price Target to $58

The U.S. Securities and Exchange Commission (SEC) announced Thursday that it has charged two affiliates of JPMorgan Chase &amp; Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/JPM#NYSE">JPM</a>) in five separate enforcement actions resulting in penalties and voluntary payments to investors of <a href="https://www.benzinga.com/markets/equities/24/10/41590849/jpmorgan-sues-customers-over-infinite-money-glitch-that-went-viral-on-tiktok-theyre-held-account">more than $151 million. </a>
The Details: The SEC<a href="https://www.sec.gov/newsroom/press-releases/2024-178"> charged</a> J.P. Morgan Securities LLC and J.P. Morgan Investment Management Inc. in five separate enforcement actions. Among the violations the agency flagged: misleading disclosures to investors, breach of fiduciary duty, prohibited joint transactions and principal trades, and failures to make recommendations in the best interest of customers. 
The JPMorgan affiliates agreed to pay more than $151 million in combined civil penalties and voluntary payments to investors to resolve the actions. The firm did not admit nor deny the findings in the SEC's orders. 
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"JPMorgan's conduct across multiple business lines violated various laws designed to protect investors from the risks of self-dealing and conflicts of interest," said Sanjay Wadhwa, Acting Director of the SEC's Division of Enforcement. 
"With today's settlements, which include multiple self-reports and large voluntary payments to harmed investors, JP Morgan is being held accountable for its regulatory failures," Wadhwa added.&nbsp;
One of the enforcement actions against J.P. Morgan Securities found that the firm made misleading disclosures to customers who invested in its Conduit private funds products which resulted in complaints from clients after the value of certain shares declined significantly.  
As part of the resolution, J.P. Morgan Securities agreed to make a voluntary payment of $90 million to more than 1,500 Conduit investor accounts. It also agreed to pay a civil penalty of $10 million, which will also be distributed to Conduit investors. 
Price Action: According to <a href="https://pro.benzinga.com/?gspk=YWRhbWVja2VydDUzMzY&amp;gsxid=zBMR4PKmcgBw">Benzinga Pro</a>, JPMorgan shares are up 0.09 % at $222.13 at the time of publication Friday.
Read Also:&nbsp;
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</ul>
Image: Shutterstock&nbsp;

Large Cap

Legal

JPMorgan To Pay Investors $151 Million After SEC Flags 'Various Law Violations'

Oppenheimer analyst Ittai Kidron maintains Atlassian (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TEAM#NASDAQ">TEAM</a>) with a Outperform and raises the price target from $230 to $270.

TEAM

Oppenheimer Maintains Outperform on Atlassian, Raises Price Target to $270

JP Morgan analyst Tien-Tsin Huang maintains Mastercard (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MA#NYSE">MA</a>) with a Overweight and lowers the price target from $593 to $580.

JP Morgan Maintains Overweight on Mastercard, Lowers Price Target to $580

Keybanc analyst Justin Patterson maintains Uber Technologies (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UBER#NYSE">UBER</a>) with a Overweight and lowers the price target from $90 to $85.

UBER

Keybanc Maintains Overweight on Uber Technologies, Lowers Price Target to $85

Oppenheimer analyst Jason Helfstein maintains Amazon.com (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMZN#NASDAQ">AMZN</a>) with a Outperform and raises the price target from $220 to $230.

AMZN

Oppenheimer Maintains Outperform on Amazon.com, Raises Price Target to $230

<ul>
<li>AMZN</li>
<li>INTC</li>
<li>NVDA</li>
<li>AAPL</li>
<li>DJT</li>
<li>SMCI</li>
<li>LOT</li>
<li>AMD</li>
<li>MSFT</li>
<li>META</li>
</ul>
Data from <a href="https://swaggystocks.com/dashboard/wallstreetbets/ticker-sentiment">https://swaggystocks.com/dashboard/wallstreetbets/ticker-sentiment</a>
&nbsp;

Trading Ideas

AAPL

INTC

MSFT

NVDA

SMCI

Top 10 Trending Stocks On WallStreetBets As Of November 1, 2024 (Via Swaggy Stocks)

Morgan Stanley analyst Terence Flynn maintains Merck &amp; Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MRK#NYSE">MRK</a>) with a Equal-Weight and lowers the price target from $130 to $123.

Morgan Stanley Maintains Equal-Weight on Merck & Co, Lowers Price Target to $123

NRIM

Northrim BanCorp Acquires Sallyport Commercial Finance In All Cash Transaction Valued At $53.9M

<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4292490-1&amp;h=325971108&amp;u=https%3A%2F%2Fwww.aon.com%2Fen%2F&amp;a=Aon+plc">Aon plc</a> (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/AON#NYSE">AON</a>), a leading global professional services firm, today announced the signing of a definitive agreement to acquire UK-based insurance broker Griffiths &amp; Armour. Upon completion of the transaction, Griffiths &amp; Armour will become wholly-owned by Aon UK Limited and is proposed to go to market as "Griffiths &amp; Armour, an Aon company".
The acquisition closely aligns with Aon's strategy to further expand its presence in the UK and Ireland. The combination will provide a greater breadth of solutions for clients across both Aon and Griffiths &amp; Armour with complementary strengths that create a platform for further growth in the UK, Ireland and beyond. Together, Aon and Griffiths &amp; Armour share a strong cultural alignment through an unwavering focus on clients and colleagues.

Aon To Acquire UK-Based Insurance Broker Griffiths & Armour; Financial Terms Not Disclosed

Morgan Stanley analyst Lauren Schenk maintains Peloton Interactive (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PTON#NASDAQ">PTON</a>) with a Equal-Weight and raises the price target from $3.5 to $5.

PTON

Morgan Stanley Maintains Equal-Weight on Peloton Interactive, Raises Price Target to $5

Keybanc analyst Noah Zatzkin maintains Malibu Boats (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MBUU#NASDAQ">MBUU</a>) with a Overweight and raises the price target from $38 to $50.

MBUU

Keybanc Maintains Overweight on Malibu Boats, Raises Price Target to $50

Bank of America Securities analyst Alec Stranahan has reiterated their bullish stance on SWTX stock, giving a Buy rating today. Alec Stranahan has ...

Strong Q2 Performance and Promising Drug Pipeline Bolster Buy Rating for Springworks Therapeutics

SpringWorks Therapeutics Recent Developments Move This To Speculative Buy (Upgrade)

Druckenmiller's Duquesne pares Apple, Coupang, adds Adobe, TeraWulf, others

Analyst Robert Burns from H.C. Wainwright reiterated a Buy rating on Springworks Therapeutics (SWTX – Research Report) and keeping the price target...

Buy Rating Affirmed for Springworks Therapeutics on Strong Outlook for Mirdametinib

FDA accepts SpringWorks application for mirdametinib for NF1-PN

FDA accepts SpringWorks' application for mirdametinib for NF1-PN

Tracking Stanley Druckenmiller's Duquesne Family Office Portfolio - Q2 2024 Update

Goldman Sachs analyst Corinne Johnson has reiterated their bullish stance on SWTX stock, giving a Buy rating on August 28. Corinne Johnson has give...

Strong Buy Rating for Springworks Therapeutics as Mirdametinib Shows Promise in NF1-PN Treatment

J.P. Morgan analyst Anupam Rama maintained a Buy rating on Springworks Therapeutics (SWTX – Research Report) today and set a price target of $68.00...

Springworks Therapeutics: Promising Outlook for Ogsiveo Drives Overweight Rating and Elevated Price Target

In a report released today, Yaron Werber from TD Cowen maintained a Buy rating on Springworks Therapeutics (SWTX – Research Report), with a price t...

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SpringWorks Therapeutics

Vendite allo scoperto

SpringWorks Therapeutics (NASDAQ:SWTX) Azioni, Report sulle vendite allo scoperto

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