La vendita allo scoperto per Upwork dà agli investitori un'idea del grado in cui gli investitori stanno scommettendo sul declino delle azioni di Upwork. I dati relativi alle vendite allo scoperto vengono aggiornati ogni due settimane.

Upwork (NASDAQ:UPWK) Azioni, Report sulle vendite allo scoperto

Upwork

Upwork Inc is a United States-based company that operates an online marketplace that enables businesses to find and work with skilled independent professionals. The company develops platform for hiring and freelancing purposes. Its products offering include Upwork Basic, Upwork Plus, Upwork Business, Upwork Enterprise, and Upwork Payroll. The business generates revenue from Talent and Clients across the USA, India, the Philippines and the rest of the world. Substantial income is derived from providing services to clients.

Upwork Inc

Citigroup analyst Keith Horowitz upgrades U.S. Bancorp (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/USB#NYSE">USB</a>) from Neutral to Buy and raises the price target from $49 to $65.

News

Upgrades

Price Target

Analyst Ratings

Citigroup Upgrades U.S. Bancorp to Buy, Raises Price Target to $65

HC Wainwright &amp; Co. analyst Yi Chen downgrades Mainz Biomed (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MYNZ#NASDAQ">MYNZ</a>) from Buy to Neutral.

Downgrades

MYNZ

HC Wainwright & Co. Downgrades Mainz Biomed to Neutral

As a result of the independent investigation and forensic analysis, the company identified that a single employee with responsibility for small package delivery expense accounting intentionally made erroneous accounting accrual entries to hide approximately $132 to $154 million of cumulative delivery expenses from the fourth quarter of 2021 through fiscal quarter ended November 2, 2024.
&nbsp;During this same time period, the company recognized approximately $4.36 billion of delivery expenses. There is no indication that the erroneous accounting accrual entries had any impact on the company's cash management activities or vendor payments.&nbsp;
The individual who engaged in this conduct is no longer employed by the company. The investigation has not identified involvement by any other employee.
&nbsp;

Macy's Says Identified An Issue Related To Delivery Expenses In One Of Its Accrual Accounts; Consequently Initiated An Independent Investigation

Positive high-level results from the CAPItello-281 Phase III trial showed that AstraZeneca's Truqap (capivasertib) in combination with abiraterone and androgen deprivation therapy (ADT) demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of radiographic progression-free survival (rPFS) versus abiraterone and ADT with placebo in patients with PTEN-deficient de novo metastatic hormone-sensitive prostate cancer (mHSPC).
Overall survival (OS) data were immature at the time of this analysis; however, the Truqap combination showed an early trend towards an OS improvement versus abiraterone and ADT with placebo. The trial will continue as planned to further assess OS as a key secondary endpoint.
Prostate cancer is the second most prevalent cancer in men and the fifth leading cause of male cancer death globally.1 Only one third of patients with metastatic prostate cancer survive five years after diagnosis.2 Newly diagnosed mHSPC is an aggressive form of the disease associated with poor outcomes and survival.3,4 Approximately 200,000 patients are diagnosed with mHSPC each year, and one in four have PTEN-deficient tumours.5 Patients with a tumour biomarker of PTEN deficiency have a particularly poor prognosis.6
Karim Fizazi, MD, PhD, Institut Gustave Roussy, and University of Paris Saclay in Villejuif, France, and principal investigator for the trial said: "Patients with this aggressive form of prostate cancer with tumour PTEN deficiency currently face a particularly poor prognosis, and there is an urgent need for new treatments that improve upon current therapies. The results seen with capivasertib in combination with abiraterone-prednisone and androgen deprivation therapy in the CAPItello-281 trial represent a step forward for these patients."
Susan Galbraith, Executive Vice President, Oncology R&amp;D, AstraZeneca, said: "These results show for the first time, that adding an AKT inhibitor to a standard-of-care therapy can provide benefit to patients with a biomarker of PTEN-deficient metastatic hormone-sensitive prostate cancer. By targeting a key driver of the disease, we have been able to improve upon current therapies and demonstrate the potential role of this combination in an area of critical unmet need. It will be important to see greater maturity in key secondary endpoints including overall survival."
The safety profile of&nbsp;Truqap&nbsp;in combination with abiraterone and ADT in CAPItello-281 was broadly consistent with the known profile of each medicine.
Data will be presented at a forthcoming medical meeting and shared with global regulatory authorities.
Notes
Prostate cancer Prostate cancer is the second most prevalent cancer in men and the fifth leading cause of male cancer death globally, with an incidence of more than 1.4 million and approximately 397,000 deaths in 2022.1
Metastatic prostate cancer is associated with a significant mortality rate, with only one third of patients surviving five years after diagnosis.2 Development of prostate cancer is often driven by male sex hormones called androgens, including testosterone.7
Metastatic hormone-sensitive prostate cancer In patients with mHSPC, also known as metastatic castration-sensitive prostate cancer (mCSPC), prostate cancer cells need high levels of androgens to drive cancer growth.4,7 Hormone therapies, such as ADT, are widely used to block the action of male sex hormones and lower the levels of androgens in the body.4,8 However, resistance to these therapies is common and there is a need to extend their use to delay disease progression and castration resistance, where the prostate cancer grows and spreads to other parts of the body despite the use of these therapies.3,4,8
In patients with de novo mHSPC, the cancer has spread to distant parts of the body at the time of first diagnosis.9
PTEN-loss or deficiency fuels the growth of cancer cells, leading to dysregulation of the PI3K/AKT pathway, and is associated with poor outcomes in patients with prostate cancer.6,10
CAPItello-281 CAPItello-281 is a Phase III, double-blind, randomised trial evaluating the efficacy and safety of Truqap in combination with abiraterone and ADT versus abiraterone and ADT in combination with placebo in the treatment of patients with PTEN-deficient de novo mHSPC.
The global trial enrolled 1,012 adult patients with histologically confirmed de novo hormone-sensitive prostate adenocarcinoma and PTEN deficiency as confirmed by central testing. The primary endpoint of the CAPItello-281 trial is rPFS as assessed by investigator, with OS as a secondary endpoint.
Truqap Truqap is a first-in-class, potent, adenosine triphosphate (ATP)-competitive inhibitor of all three AKT isoforms (AKT1/2/3). Truqap 400mg is administered twice daily according to an intermittent dosing schedule of four days on and three days off. This was chosen in early phase trials based on tolerability and the degree of target inhibition.
Truqap is approved in the US, EU, Japan and several other countries for the treatment of adult patients with HR-positive (or ER-positive), HER2-negative locally advanced or metastatic breast cancer with one or more biomarker alterations (PIK3CA, AKT1 or PTEN) following recurrence or progression on or after an endocrine-based regimen based on the results from the CAPItello-291 trial. Truqap is also approved in Australia for the treatment of adult patients with HR-positive, HER2-negative locally advanced or metastatic breast cancer following recurrence or progression on or after an endocrine based regimen based on these trial results.
Truqap is currently being evaluated in Phase III trials for the treatment of breast cancer (CAPItello-292) and prostate cancer (CAPItello-280 and CAPItello-281) in combination with established treatments.
Truqap was discovered by AstraZeneca subsequent to a collaboration with Astex Therapeutics (and its collaboration with the Institute of Cancer Research and Cancer Research Technology Limited).
AstraZeneca in oncology AstraZeneca is leading a revolution in oncology with the ambition to provide cures for cancer in every form, following the science to understand cancer and all its complexities to discover, develop and deliver life-changing medicines to patients.
The Company's focus is on some of the most challenging cancers. It is through persistent innovation that AstraZeneca has built one of the most diverse portfolios and pipelines in the industry, with the potential to catalyse changes in the practice of medicine and transform the patient experience.
AstraZeneca has the vision to redefine cancer care and, one day, eliminate cancer as a cause of death.

AstraZeneca's Truqap Demonstrates Progress in Advanced Prostate Cancer Treatment

Citigroup analyst Anthony Pettinari reinstates Berry Global Gr (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BERY#NYSE">BERY</a>) with a Neutral and announces $76 price target.

Initiation

BERY

Citigroup Reinstates Neutral on Berry Global Gr, Announces $76 Price Target

Macy's Says November Comparable Sales Are Trending Ahead Of Q3 Levels Across Nameplates

Guidance

Macy's Delays Q3 Earnings Release And Conference Call; Reports Preliminary Net Sales Decrease Of 2.4% To $4.742Bn, With Comparable Sales Down 2.4% On An Owned Basis

Bath &amp; Body Works (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BBWI#NYSE">BBWI</a>) reported quarterly earnings of $0.49 per share which beat the analyst consensus estimate of $0.47 by 4.26 percent. This is a 2.08 percent increase over earnings of $0.48 per share from the same period last year. The company reported quarterly sales of $1.610 billion which beat the analyst consensus estimate of $1.579 billion by 1.98 percent. This is a 3.07 percent increase over sales of $1.562 billion the same period last year.

Earnings

Earnings Beats

BBWI

Bath & Body Works Q3 2024 Adj. EPS $0.49 Beats $0.47 Estimate, Sales $1.610B Beat $1.579B Estimate

Citigroup analyst Keith Horowitz downgrades M&amp;T Bank (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MTB#NYSE">MTB</a>) from Buy to Neutral and raises the price target from $220 to $230.

Citigroup Downgrades M&T Bank to Neutral, Raises Price Target to $230

Needham analyst Serge Belanger reiterates Viridian Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VRDN#NASDAQ">VRDN</a>) with a Buy and maintains $38 price target.

Reiteration

VRDN

Needham Reiterates Buy on Viridian Therapeutics, Maintains $38 Price Target

Nu Holdings Ltd. ("Nu Holdings"of "Company") informs its shareholders and the market that the Financial Superintendence of Colombia ("SFC") has formally approved the merger of its Colombian entity Nu Colombia S.A. into Nu. Colombia Compañía de Financiamiento S.A..
The merger, which consolidates the accounts and operations in the country into one single entity (Nu. Colombia Compañía de Financiamiento S.A.) supervised by the SFC, reinforces the Company's long-term vision and commitment to Colombia and will allow the expansion of its portfolio of products and services in the future.

Nu Holdings Consolidates Colombian Operations, Expanding Future Financial Services

Needham analyst Scott Berg reiterates Workday (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WDAY#NASDAQ">WDAY</a>) with a Buy and maintains $300 price target.

WDAY

Needham Reiterates Buy on Workday, Maintains $300 Price Target

Freightos Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CRGO#NASDAQ">CRGO</a>), a leading vendor-neutral digital booking and payment platform for the international freight industry, today announced that Ran Shalev, Chief Financial Officer, has decided to conclude his tenure effective December 31, 2024, to pursue another role. The company is in the process of a search for a successor. In order to ensure continuity, Mr. Shalev has agreed following his departure to actively assist with ongoing operations and with handover throughout Q1.
&nbsp;
Mr. Shalev has served as Freightos' CFO since 2016, overseeing the company's financial operations during a transformative period that included its public listing on Nasdaq, the successful execution of multiple strategic acquisitions, and consistent growth in revenue and transaction volumes.

Management

CRGO

Freightos To Deaprt As CFO Effective December 31 To Pursue Another Job, Company In Process Of Finding A Successor

<ul>
<li>Amglidia is a proprietary, patented liquid product that was developed for the treatment of neonatal diabetes mellitus by AMMTeK, a French biotechnology company. The product was approved by the EMA in 2018.&nbsp;</li>
<li>The product has already been granted Orphan Drug Designation by the U.S. FDA. Neonatal diabetes mellitus is a rare condition estimated to impact approximately 300 patients in the United States.&nbsp;</li>
<li>Currently, there are no FDA-approved oral treatment options and as a result, U.S. patients frequently either rely on compounded products that are not FDA-approved or administer products off-label by making homemade suspensions.</li>
<li>AMMTeK has conducted a post-approval study tracking five years of real-world safety and efficacy in European patients, which will be used to support Eton's NDA submission. Eton plans to hold a meeting with the FDA in the first quarter of 2025 and anticipates submitting an NDA for the product in 2026.</li>
</ul>

Health Care

General

ETON

Eton Pharmaceuticals Has Acquired The Us Rights To Amglidia (Glyburide Oral Suspension, Known As Glibenclamide In Europe) For Neonatal Diabetes Mellitus From AMMTeK, Potential US Marketing Application Submission Expected In 2026

Loop Capital analyst Garik Shmois downgrades Eagle Materials (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EXP#NYSE">EXP</a>) from Buy to Hold and maintains the price target from $315 to $315.

Loop Capital Downgrades Eagle Materials to Hold, Maintains Price Target to $315

Wolfe Research analyst Andrew Rosivach upgrades Jones Lang LaSalle (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/JLL#NYSE">JLL</a>) from Peer Perform to Outperform and announces $353 price target.

Wolfe Research Upgrades Jones Lang LaSalle to Outperform, Announces $353 Price Target

Merck (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MRK#NYSE">MRK</a>), known as MSD outside of the United States and Canada, announced today positive topline results from the Phase 3 ZENITH study evaluating WINREVAIR (sotatercept-csrk) in adults with pulmonary arterial hypertension (PAH, WHO&#x2A; Group 1) functional class (FC) III or IV at high risk of mortality. ZENITH met its primary endpoint of time to first morbidity or mortality event (all-cause death, lung transplantation, or PAH worsening related hospitalization of ≥ 24 hours). In the study, WINREVAIR demonstrated a statistically significant and clinically meaningful reduction in the risk of morbidity or mortality events compared to placebo, both on top of background PAH therapy. Based on the strength of these results, an independent data monitoring committee has recommended ZENITH be stopped early and all participants be offered the opportunity to receive WINREVAIR through the SOTERIA open-label extension study. In preliminary assessment, adverse events and serious adverse events were balanced between the treatment groups.
"PAH is a serious, progressive disease with a high incidence of morbidity and mortality," said Dr. Eliav Barr, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories. "Based on the primary endpoint demonstrating overwhelming efficacy, all ZENITH study participants will be offered the opportunity to receive WINREVAIR. These findings are impressive, set a high evidentiary bar for studies of future candidates developed for the treatment of PAH and support the potential of WINREVAIR to be practice-changing in the management of PAH."
"The ZENITH trial was designed to evaluate whether the addition of WINREVAIR, an activin signaling inhibitor, could reduce the risk of death, lung transplantation, or PAH hospitalizations for patients living with advanced PAH," said Dr. Vallerie McLaughlin&#x2A;&#x2A;, Kim A Eagle MD Endowed Professor of Cardiovascular Medicine and Director, Pulmonary Hypertension Program, University of Michigan in Ann Arbor. "This is the first study in PAH in which the interim analysis led to an early conclusion of the study due to overwhelming efficacy. WINREVAIR has brought significant optimism to the field, and we thank the investigators and patients for being part of this important study."
WINREVAIR is currently approved in the U.S. and 36 countries based on the results from the Phase 3 STELLAR trial. Most recently, in November of this year, WINREVAIR was submitted for approval in Japan based on the STELLAR trial and results from an open-label Phase 3 study in Japanese patients.
Results from ZENITH will be presented at an upcoming medical meeting and will be submitted to regulatory authorities.

Merck's WINREVAIR Achieves Results in PAH Study, Trial Ends Early on Efficacy

Wolfe Research analyst Andrew Rosivach downgrades Newmark Group (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NMRK#NASDAQ">NMRK</a>) from Outperform to Peer Perform.

NMRK

Wolfe Research Downgrades Newmark Group to Peer Perform

Barclays analyst Ramsey El-Assal initiates coverage on MARA Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MARA#NASDAQ">MARA</a>) with a Equal-Weight rating and announces Price Target of $27.

MARA

Barclays Initiates Coverage On MARA Holdings with Equal-Weight Rating, Announces Price Target of $27

Barclays analyst Lydia Rainforth upgrades Equinor (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EQNR#NYSE">EQNR</a>) from Equal-Weight to Overweight.

EQNR

Barclays Upgrades Equinor to Overweight

In a report released today, Marvin Fong from BTIG maintained a Buy rating on Upwork (UPWK – Research Report), with a price target of $16.00. The co...

BTIG Reaffirms Their Buy Rating on Upwork (UPWK)

Bernie McTernan, an analyst from Needham, reiterated the Buy rating on Upwork (UPWK – Research Report). The associated price target was raised to $...

Buy Rating Maintained Despite Lowered 2025 Projections and Cost-Cutting Initiatives

Companies in the Industrial Goods sector have received a lot of coverage today as analysts weigh in on Upwork (UPWK – Research Report), ZipRecruite...

Analysts Offer Insights on Industrial Goods Companies: Upwork (UPWK), ZipRecruiter (ZIP) and Ushio (OtherUHOIF)

Canaccord analyst Maria Ripps raised the firm's price target on Upwork (UPWK) to $18 from $15 and keeps a Buy rating on the shares. The firm said i...

Upwork price target raised to $18 from $15 at Canaccord

In a report released today, Rohit Kulkarni from Roth MKM maintained a Buy rating on Upwork (UPWK – Research Report), with a price target of $20.00....

Roth MKM Sticks to Their Buy Rating for Upwork (UPWK)

Roth MKM raised the firm's price target on Upwork (UPWK) to $20 from $13 and keeps a Buy rating on the shares. The company's Q4 EBITDA guide came c...

Upwork price target raised to $20 from $13 at Roth MKM

JMP Securities raised the firm's price target on Upwork (UPWK) to $18 from $14 and keeps an Outperform rating on the shares. Upwork reported strong...

Upwork price target raised to $18 from $14 at JMP Securities

RBC Capital analyst Brad Erickson maintained a Hold rating on Upwork (UPWK – Research Report) on November 7 and set a price target of $16.00. The c...

RBC Capital Keeps Their Hold Rating on Upwork (UPWK)

13 Cheap small/mid-cap buy-rated stocks with higher Beta

Upwork: Disciplined Cost Reduction, Platform Improvements - Buy

ASTH

BOOT

GPRE

PFGC

SOFI

TMSL

UHOIF

UPWK

Press Releases

Upwork Reports Second Quarter 2024 Financial Results

Upwork to Present at Goldman Sachs Communacopia + Technology Conference

Engine Capital Sends Letter to Upwork's Board of Directors Regarding Opportunities to Substantially Increase Shareholder Value

Upwork Confirms Receipt and Comments on Shareholder Letter

Upwork Study Finds Companies That Integrate Distributed Work, Flexible Talent Strategies, and Advanced Technology Achieve Better Financial Outcomes

Upwork to Report Third Quarter Financial Results on November 6, 2024

Upwork Expands AI Innovation and Unveils New Solutions for Better Work Outcomes with Upwork Updates Fall 2024 Release

Upwork Announces Organizational Changes to Drive Continued Profitable Growth and Provides Preliminary Third Quarter 2024 Results Above Financial Guidance

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Upwork (NASDAQ:UPWK) Azioni, Report sulle vendite allo scoperto

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